INT112191

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 12.40
Pain Relevance 7.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophage 6
liver 4
lung 4
cerebrum 2
paw 2
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2 100.00 Very High Very High Very High
Spinal cord 1 100.00 Very High Very High Very High
fluoxetine 16 99.84 Very High Very High Very High
Inflammation 118 99.52 Very High Very High Very High
Paracetamol 64 98.92 Very High Very High Very High
Thermal hyperalgesia 5 96.60 Very High Very High Very High
cytokine 182 95.88 Very High Very High Very High
Antinociceptive 4 95.48 Very High Very High Very High
tetrodotoxin 4 94.88 High High
lidocaine 10 93.60 High High
Disease Link Frequency Relevance Heat
Necrosis 31 100.00 Very High Very High Very High
Cancer 31 100.00 Very High Very High Very High
Adhesions 4 100.00 Very High Very High Very High
Cold Sores 428 99.84 Very High Very High Very High
Obesity 119 99.76 Very High Very High Very High
Influenza Virus Infection 120 99.74 Very High Very High Very High
INFLAMMATION 138 99.52 Very High Very High Very High
Sprains And Strains 19 99.48 Very High Very High Very High
Parkinson's Disease 109 99.06 Very High Very High Very High
Infection 428 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrated that LPS significantly upregulated transcription of iNOS and CAT-2 but not GTPCH in stimulated macrophages.
Neg (not) Positive_regulation (upregulated) of Transcription (transcription) of iNOS in macrophages
1) Confidence 0.66 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717319 Disease Relevance 0 Pain Relevance 1.11
Further, Imanishi et al. pointed out that a mouse lung-adapted strain of influenza virus could induce NOS-2 mRNA expression and NOS-2-mediated NO production in murine macrophage cells [5].
Positive_regulation (induce) of Transcription (expression) of NOS-2 in macrophage associated with influenza virus infection and sprains and strains
2) Confidence 0.57 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.72 Pain Relevance 0.11
These results suggested that DHCD inhibited NO generation by blocking NF-kappaB activation and iNOS gene transcription.
Positive_regulation (activation) of Transcription (transcription) of iNOS
3) Confidence 0.50 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14752064 Disease Relevance 0.08 Pain Relevance 0.17
The mRNA level of nitric oxide synthase (iNos, Nos2) by RT-PCR was also stimulated by fluoxetine.
Positive_regulation (stimulated) of Transcription (level) of Nos2 associated with fluoxetine
4) Confidence 0.48 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.19 Pain Relevance 0.67
The mRNA level of nitric oxide synthase (iNos, Nos2) by RT-PCR was also stimulated by fluoxetine.
Positive_regulation (stimulated) of Transcription (level) of iNos associated with fluoxetine
5) Confidence 0.48 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.19 Pain Relevance 0.67
Recent in vitro studies by Imanishi et al. showed that a mouse lung-adapted strain of influenza virus could induce inducible NO synthase (NOS-2) mRNA expression and NOS-2-mediated NO production in murine macrophage cell [5].
Positive_regulation (induce) of Transcription (expression) of NOS-2 in lung associated with influenza virus infection and sprains and strains
6) Confidence 0.47 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 1.17 Pain Relevance 0.19
Moreover, iNOS mRNA expression in the lumbar enlargement segments of the spinal cord was dramatically induced at 24 h (late phase) after injection of carrageenan into a hind paw.
Positive_regulation (induced) of Transcription (expression) of iNOS in paw associated with spinal cord
7) Confidence 0.47 Published 2003 Journal Neuroscience Section Abstract Doc Link 12895524 Disease Relevance 0.70 Pain Relevance 0.61
GSNO effectively blocked MAFbx/atrogin-1 mRNA expression induced by LPS (Fig. 5A and 5B) and promoted iNos mRNA expression both with and without LPS injection (Fig. 5C and 5D).
Positive_regulation (promoted) of Transcription (expression) of iNos
8) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.14 Pain Relevance 0.03
RESULTS: TFR 100, 200 mg/kg ig remarkably prolonged the latencies of licking paws in mice. 100 mg/kg TFR ig significantly increased the mice serum NO content, and 200 mg/kg TFR ig markedly increased the NO content as well as promoted the iNOS mRNA expression in mice cerebrum.
Neg (NO) Positive_regulation (increased) of Transcription (expression) of iNOS in cerebrum
9) Confidence 0.45 Published 2007 Journal Zhong Yao Cai Section Body Doc Link 17571769 Disease Relevance 0 Pain Relevance 0
Moreover, mRNA expression of adhesion molecules, several chemokines, interferon-gamma (IFN-gamma), and inducible nitric oxide synthase (iNOS) was enhanced in the liver.
Positive_regulation (enhanced) of Transcription (expression) of iNOS in liver associated with chemokine and adhesions
10) Confidence 0.45 Published 2004 Journal J. Leukoc. Biol. Section Abstract Doc Link 14557383 Disease Relevance 1.28 Pain Relevance 0.81
Moreover, mRNA expression of adhesion molecules, several chemokines, interferon-gamma (IFN-gamma), and inducible nitric oxide synthase (iNOS) was enhanced in the liver.
Positive_regulation (enhanced) of Transcription (expression) of inducible nitric oxide synthase in liver associated with chemokine and adhesions
11) Confidence 0.45 Published 2004 Journal J. Leukoc. Biol. Section Abstract Doc Link 14557383 Disease Relevance 1.28 Pain Relevance 0.81
The gene expression levels of Prdm16, a zinc-finger protein that stimulates brown fat-selective gene expression, was significantly down-regulated (p<0.001) in ob/ob mice, while the deletion of iNOS increased mRNA expression levels although only a marginal statistical significance was found (p?
Positive_regulation (increased) of Transcription (deletion) of iNOS in finger associated with obesity
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.97 Pain Relevance 0
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Transcription (transcription) of iNOS associated with necrosis and cancer
13) Confidence 0.43 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.25
Further, Imanishi et al. pointed out that a mouse lung-adapted strain of influenza virus could induce NOS-2 mRNA expression and NOS-2-mediated NO production in murine macrophage cells [5].
Positive_regulation (induce) of Transcription (expression) of NOS-2-mediated in macrophage associated with influenza virus infection and sprains and strains
14) Confidence 0.41 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.78 Pain Relevance 0.11
Over-production of NO was substantiated by determining an increase in the expression of NOS-2 mRNA as shown in Fig. 2, and increased immuno-histochemical staining for anti-NOS-2 as shown in Fig. 4.
Spec (determining) Positive_regulation (increase) of Transcription (expression) of NOS-2
15) Confidence 0.38 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.20 Pain Relevance 0
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Transcription (transcription) of inducible nitric oxide synthase associated with necrosis and cancer
16) Confidence 0.37 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.25
On the other hand, the MPTP mice fed with HCT1026 exhibited significantly less iNOS mRNA expression compared to controls (Figure 7C).
Positive_regulation (less) of Transcription (expression) of iNOS associated with parkinson's disease
17) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.76 Pain Relevance 0.15
LPS treatment increased iNOS mRNA level in the lung approximately 20-fold of normal level.
Positive_regulation (increased) of Transcription (level) of iNOS in lung
18) Confidence 0.27 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.23 Pain Relevance 0.08
-stimulated iNOS protein and mRNA expression via inhibiting NF-?
Positive_regulation (stimulated) of Transcription (expression) of iNOS protein
19) Confidence 0.25 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC1978242 Disease Relevance 0.68 Pain Relevance 0.47
PZ administration 2 h before LPS significantly reduced the increase in iNOS mRNA gene expression by around 50%.
Positive_regulation (increase) of Transcription (expression) of iNOS
20) Confidence 0.20 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.22 Pain Relevance 0.07

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