INT112207

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 7.10
Pain Relevance 15.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
sensory neurons 2
pore 1
brain 1
skeletal muscle 1
central nervous system 1
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 125 100.00 Very High Very High Very High
nav1.8 111 100.00 Very High Very High Very High
nociceptor 87 100.00 Very High Very High Very High
nav1.3 70 100.00 Very High Very High Very High
Nav1.6 62 100.00 Very High Very High Very High
Nav1.2 60 100.00 Very High Very High Very High
Neuronal excitability 8 100.00 Very High Very High Very High
sodium channel 381 99.98 Very High Very High Very High
IPN 10 99.72 Very High Very High Very High
Peripheral nervous system 6 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 73 99.92 Very High Very High Very High
Nervous System Injury 23 99.74 Very High Very High Very High
Inflammatory Pain 37 99.72 Very High Very High Very High
Erythermalgia 15 99.52 Very High Very High Very High
Demyelinating Disease 11 99.28 Very High Very High Very High
Autism 4 98.72 Very High Very High Very High
Ganglion Cysts 139 97.48 Very High Very High Very High
INFLAMMATION 45 96.64 Very High Very High Very High
Neuropathic Pain 114 95.96 Very High Very High Very High
Targeted Disruption 176 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover Gee and coworkers observed, in vitro, that the C-terminal biotinylated peptide of Nav1.4 binds syntrophin via its PDZ domain (Gee et al., 1998).
Nav1 Binding (binds) of
1) Confidence 0.47 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
For analgesic design it suggests further possibilities: design of a moiety that can bind to the Nav1.7 sodium pore; and discovery, and then inhibition, of the chaperone protein that correctly folds Nav1.7 prior to its trafficking to the membrane.



Nav1.7 Binding (bind) of in pore associated with analgesic and nav1.7
2) Confidence 0.46 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.25 Pain Relevance 0.56
Thus, the paranodal junction significantly influences the retention of Nav1.6 in the node, which is followed by disorganization of nodal structures.
Nav1 Binding (retention) of in node associated with nav1.6
3) Confidence 0.37 Published 2004 Journal Glia Section Abstract Doc Link 15048850 Disease Relevance 0.07 Pain Relevance 1.10
Therefore, the role of Nav1.7 in sensory neurons where Nav1.8 is not expressed (and which do not express Cre) remains to be studied.
Nav1 Binding (role) of in sensory neurons associated with nav1.8 and nav1.7
4) Confidence 0.37 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 0.94 Pain Relevance 2.18
Nav1.3 and neuronal excitability
Nav1 Binding (excitability) of in neuronal associated with nav1.3 and neuronal excitability
5) Confidence 0.37 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.75 Pain Relevance 1.85
We also show that blocking the interaction of CaM and Nav1.8 using CBP or the IQ/DE substitution causes a buildup of inactivated channels and, in the case of the IQ/DE mutation, stimulation even at a low frequency of 0.1 Hz significantly enhances the frequency-dependent inhibition of the Nav1.8 current.
Nav1 Binding (interaction) of associated with nav1.8
6) Confidence 0.37 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16598065 Disease Relevance 0.38 Pain Relevance 1.33
Interestingly, Nav1.4 in our experiments with skeletal muscle colocalized with syntrophin, similarly to what has been described for the cardiac isoform Nav1.5 (Gee et al., 1998; Gavillet et al., 2006).
Nav1 Binding (experiments) of in skeletal muscle
7) Confidence 0.36 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.05 Pain Relevance 0.04
It may be that Nav 1.8 VGSCs are localised to a population of mechanosensitive fibres, or possibly associated with another transducer responsible for mechanosensation.
Nav Binding (associated) of associated with mechanosensation
8) Confidence 0.35 Published 2006 Journal Mol Pain Section Body Doc Link PMC1403745 Disease Relevance 0.18 Pain Relevance 0.19
We show here that adult-onset chronic demyelination, such as occurs in demyelinating disorders and after nerve injury, alters the complement of axonal voltage-dependent Na+ (Nav) channel isoforms and their localization.
Nav Binding (complement) of in nerve associated with demyelination, nervous system injury and demyelinating disease
9) Confidence 0.33 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898531 Disease Relevance 0.77 Pain Relevance 0.47
During single pulse experiments for a reduced model we obtained quite similar threshold characteristics in spite of either assuming constant channel densities within every main segment or including only Nav1.2, Nav1.6, fast voltage-gated K+ channels and a linear leakage current with Eleak=?
Nav1 Binding (voltage) of associated with nav1.2 and nav1.6
10) Confidence 0.32 Published 2010 Journal Neuroscience Section Body Doc Link PMC2954315 Disease Relevance 0 Pain Relevance 0.44
During single pulse experiments for a reduced model we obtained quite similar threshold characteristics in spite of either assuming constant channel densities within every main segment or including only Nav1.2, Nav1.6, fast voltage-gated K+ channels and a linear leakage current with Eleak=?
Nav1 Binding (voltage) of associated with nav1.2 and nav1.6
11) Confidence 0.32 Published 2010 Journal Neuroscience Section Body Doc Link PMC2954315 Disease Relevance 0 Pain Relevance 0.44
During single pulse experiments for a reduced model we obtained quite similar threshold characteristics in spite of either assuming constant channel densities within every main segment or including only Nav1.2, Nav1.6, fast voltage-gated K+ channels and a linear leakage current with Eleak=?
Nav1 Binding (only) of associated with nav1.2 and nav1.6
12) Confidence 0.32 Published 2010 Journal Neuroscience Section Body Doc Link PMC2954315 Disease Relevance 0 Pain Relevance 0.44
During single pulse experiments for a reduced model we obtained quite similar threshold characteristics in spite of either assuming constant channel densities within every main segment or including only Nav1.2, Nav1.6, fast voltage-gated K+ channels and a linear leakage current with Eleak=?
Nav1 Binding (only) of associated with nav1.2 and nav1.6
13) Confidence 0.32 Published 2010 Journal Neuroscience Section Body Doc Link PMC2954315 Disease Relevance 0 Pain Relevance 0.44
The present studies demonstrate that presynaptic ephrin-B2 expressed by Nav1.8+ nociceptors has an important role in regulating to the central nervous system in conditions of inflammatory and neuropathic pain.
Nav1 Binding (nociceptors) of in central nervous system associated with inflammation, nociceptor, neuropathic pain, central nervous system and nav1.8
14) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.55 Pain Relevance 0.63
subunits cluster under the influence of a secreted factor; however, clustering of Nav1.6 ?
Nav1 Binding (clustering) of associated with nav1.6
15) Confidence 0.28 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0 Pain Relevance 0.40
As recent findings revealed an essential role of NaV1.7 in nociception (Nassar et al., 2004; Cox et al., 2006; Fertleman et al., 2006; Lee et al., 2007; Zhang et al., 2007), we tested the binding ability of Pdzd2 to NaV1.7.
NaV1 Binding (binding) of associated with nociception
16) Confidence 0.24 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.10 Pain Relevance 0.08
In addition, immunoprecipitation studies and single molecule tracking indicated a physical interaction between AQP-1 and Nav1.8.
Nav1 Binding (interaction) of associated with nav1.8
17) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.57 Pain Relevance 1.25
Antibodies against sodium channel isoforms NaV1.1 (rabbit; Alomone Laboratories, Jerusalem, Israel), NaV1.1 (mouse; Antibodies, Inc., Davis, CA), NaV1.6 (rabbit; Sigma-Aldrich Inc., St.
NaV1 Binding (rabbit) of associated with sodium channel
18) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.20 Pain Relevance 0.29
Antibodies against sodium channel isoforms NaV1.1 (rabbit; Alomone Laboratories, Jerusalem, Israel), NaV1.1 (mouse; Antibodies, Inc., Davis, CA), NaV1.6 (rabbit; Sigma-Aldrich Inc., St.
NaV1 Binding (rabbit) of associated with sodium channel
19) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.19 Pain Relevance 0.29
Pdzd2 binds to NaV1.8 and NaV1.7
NaV1 Binding (binds) of
20) Confidence 0.20 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.07

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