INT112208

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
spinal 2
neurons 2
spinal cords 2
cortex 2
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 91.24 High High
Central nervous system 3 79.64 Quite High
Opioid 1 77.72 Quite High
Inflammation 23 74.24 Quite High
Hippocampus 7 61.12 Quite High
Sciatica 4 25.00 Low Low
cINOD 4 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Abeta 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 8 100.00 Very High Very High Very High
Disease 38 98.76 Very High Very High Very High
Injury 8 98.76 Very High Very High Very High
Aging 3 82.80 Quite High
Cognitive Disorder 5 81.88 Quite High
INFLAMMATION 24 74.24 Quite High
Amyloid Plaque 9 43.52 Quite Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Stroke 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDMA treatment significantly decreased the production of APP in the cytosolic fraction of the brain cortex.
Negative_regulation (decreased) of Gene_expression (production) of APP in cortex
1) Confidence 0.59 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.28 Pain Relevance 0.40
In contrast, after avulsion, expression of APP and A/beta were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed.
Negative_regulation (downregulated) of Gene_expression (expression) of APP in spinal
2) Confidence 0.58 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.48 Pain Relevance 0
After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury.
Negative_regulation (decreased) of Gene_expression (expression) of APP in spinal cords associated with injury
3) Confidence 0.43 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.50 Pain Relevance 0
At the same time, a very recent study demonstrated that genetic removal of iNOS in mice expressing mutated amyloid precursor protein resulted in pathological hyperphosphorylation of mouse tau, its redistribution to the somatodendritic compartment in cortical and hippocampal neurons, and aggregate formation.
Negative_regulation (removal) of Gene_expression (expressing) of amyloid precursor protein in neurons associated with alzheimer's dementia
4) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.62 Pain Relevance 0.28

General Comments

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