INT112211

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 4.48
Pain Relevance 6.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a1) plasma membrane (Slc6a1)
Anatomy Link Frequency
plasma 1
retina 1
amacrine cells 1
Slc6a1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 43 100.00 Very High Very High Very High
Glutamate 8 100.00 Very High Very High Very High
Morphine 32 99.84 Very High Very High Very High
GABAergic 28 99.68 Very High Very High Very High
withdrawal 12 99.64 Very High Very High Very High
Pain 9 99.54 Very High Very High Very High
addiction 8 99.48 Very High Very High Very High
narcan 9 98.64 Very High Very High Very High
Hyperalgesia 3 97.56 Very High Very High Very High
Antinociceptive 2 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 256 100.00 Very High Very High Very High
Targeted Disruption 87 99.96 Very High Very High Very High
Morphine Dependence 8 99.84 Very High Very High Very High
Substance Withdrawal Syndrome 12 99.82 Very High Very High Very High
Pain 7 99.54 Very High Very High Very High
Cytomegalovirus Infection 1 98.36 Very High Very High Very High
Hyperalgesia 4 97.56 Very High Very High Very High
Nociception 9 96.96 Very High Very High Very High
Hypoalagesia 4 75.00 Quite High
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study further the effects of GAT1 on pain, we used two kinds of GAT1-overexpressing transgenic mice (under the control of a CMV promoter or a NSE promoter) to examine the nociceptive responses in these mice.
Gene_expression (overexpressing) of GAT1 associated with nociception, targeted disruption, pain and cytomegalovirus infection
1) Confidence 0.78 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898541 Disease Relevance 1.19 Pain Relevance 0.73
We reported previously that overexpression of the GABA transporter subtype 1 (GAT1), the major form of the GABA transporter in the CNS, led to hyperalgesia in mice.
Gene_expression (overexpression) of GAT1 associated with hyperalgesia and gaba
2) Confidence 0.78 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 17918738 Disease Relevance 0.48 Pain Relevance 0.55
We reported previously that overexpression of the GABA transporter subtype 1 (GAT1), the major form of the GABA transporter in the CNS, led to hyperalgesia in mice.
Gene_expression (overexpression) of GABA transporter subtype 1 associated with hyperalgesia and gaba
3) Confidence 0.78 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 17918738 Disease Relevance 0.48 Pain Relevance 0.55
We generated GABA transporter I (GAT1)-overexpressing mice to investigate whether the GABAergic system and GABA transporter are involved in morphine-induced reward effects and withdrawal symptoms.
Gene_expression (overexpressing) of GAT1 associated with gaba, gabaergic, withdrawal and morphine
4) Confidence 0.77 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14598306 Disease Relevance 0.38 Pain Relevance 0.96
Decrease of morphine-induced reward effects and withdrawal symptoms in mice overexpressing gamma-aminobutyric acid transporter I.
Gene_expression (overexpressing) of gamma-aminobutyric acid transporter associated with narcan, withdrawal and morphine
5) Confidence 0.67 Published 2003 Journal J. Neurosci. Res. Section Title Doc Link 14598306 Disease Relevance 0.41 Pain Relevance 1.17
Moreover, both somatic and vegetative signs of naloxone-induced morphine withdrawal symptoms were substantially reduced in GAT1-overexpressing mice.
Gene_expression (overexpressing) of GAT1-overexpressing associated with narcan, withdrawal and morphine
6) Confidence 0.67 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14598306 Disease Relevance 0.43 Pain Relevance 1.20
Our results revealed that the rewarding effects induced by morphine were significantly decreased in GAT1-overexpressing mice as measured by the conditioned place preference (CPP) paradigm.
Gene_expression (overexpressing) of GAT1-overexpressing associated with morphine
7) Confidence 0.67 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14598306 Disease Relevance 0.41 Pain Relevance 1.17
In our study, all CFP-containing amacrine cells in the INL were GABAergic based on their expression of the GABA synthetic enzyme GAD67 or the high affinity plasma membrane GABA transporter, GAT-1 [37,51-55,65].
Gene_expression (expression) of GAT-1 in plasma associated with gaba and gabaergic
8) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.07 Pain Relevance 0.24
The expression of GAD67 and GAT-1 were evaluated in the thy1-CFP mouse retina.
Gene_expression (expression) of GAT-1 in retina
9) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.13 Pain Relevance 0.09
Cell counts in the GCL showed that 12.4% and 9.2% of the CFP-containing cells in the GCL expressed GAD67 and GAT-1 immunoreactivity, respectively (Table 1).
Gene_expression (expressed) of GAT-1
10) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.05 Pain Relevance 0.08
CFP expression was characterized using morphometric methods and immunohistochemistry with antibodies to neurofilament light (NF-L), neuronal nuclei (NeuN), POU-domain protein (Brn3a) and calretinin, which immunolabel ganglion cells, and syntaxin 1 (HPC-1), glutamate decarboxylase 67 (GAD67), GABA plasma membrane transporter-1 (GAT-1), and choline acetyltransferase (ChAT), which immunolabel amacrine cells.


Gene_expression (expression) of GAT-1 in amacrine cells associated with ganglion cysts, gaba and glutamate
11) Confidence 0.16 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2519030 Disease Relevance 0.43 Pain Relevance 0.10

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