INT112214

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.59
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) nuclear chromosome (Vdr) aging (Vdr)
cell morphogenesis (Vdr) nucleus (Vdr) DNA binding (Vdr)
Vdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 11 100.00 Very High Very High Very High
antagonist 16 85.76 High High
Pain 35 85.24 High High
agonist 16 84.32 Quite High
Multiple sclerosis 1 50.96 Quite High
electroacupuncture 1 30.56 Quite Low
Acupuncture 1 26.88 Quite Low
Analgesic 3 25.00 Low Low
Osteoarthritis 2 15.56 Low Low
Bioavailability 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 348 99.88 Very High Very High Very High
Dyskinesias 1 98.92 Very High Very High Very High
Disease 3 97.08 Very High Very High Very High
Rickets 2 86.28 High High
Osteoporosis 17 85.92 High High
Bone Cancer 4 85.76 High High
Breast Cancer 16 83.24 Quite High
Hypercalcemia 42 80.36 Quite High
Cancer 28 78.64 Quite High
Pain 23 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDM02 induced the expression of VDR, OPN, osteocalcin, and ALP as important characteristics of OB differentiation.
Gene_expression (expression) of VDR
1) Confidence 0.33 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.76 Pain Relevance 0.22
M RSV, the expression of osteogenic markers such as vitamin D3 receptor (VD3R), osteocalcin, osteopontin (OPN), and alkaline phosphatase (ALP) was upregulated relative to cells not treated with PDM02 or RSV (Fig. 5).
Gene_expression (expression) of vitamin D3 receptor associated with respiratory syncytial virus
2) Confidence 0.33 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.88 Pain Relevance 0
The expression of (a) vitamin D receptor (VDR), (b) osteocalcin, (c) osteopontin, and (d) alkaline phosphatase (ALP) was quantified by real-time PCR and is shown relative to the expression of ?
Gene_expression (expression) of VDR
3) Confidence 0.33 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.62 Pain Relevance 0
The VDR is also present in a wide variety of other tissues. 1,25(OH)2D interacts with these receptors to have a multitude of important physiological effects.
Gene_expression (present) of VDR
4) Confidence 0.32 Published 2003 Journal Recent Results Cancer Res. Section Abstract Doc Link 12899511 Disease Relevance 0.48 Pain Relevance 0.11
Also, DA D2 receptor supersensitivity and increased DA D3 receptor expression are associated with motor dyskinesias, as in L-DOPA-treated Parkinson's disease patients.
Gene_expression (expression) of DA D3 receptor associated with dopamine, disease and dyskinesias
5) Confidence 0.19 Published 2004 Journal Neurotox Res Section Abstract Doc Link 15639779 Disease Relevance 0.20 Pain Relevance 0.58
In addition estrogen increases expression of the Vitamin D receptor and VDR gene via activation of ERK 1/2 signaling pathway [47, 48].
Gene_expression (expression) of Vitamin D receptor
6) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2943085 Disease Relevance 0.66 Pain Relevance 0.21

General Comments

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