INT112215

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.43
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) nuclear chromosome (Vdr) aging (Vdr)
cell morphogenesis (Vdr) nucleus (Vdr) DNA binding (Vdr)
Anatomy Link Frequency
kidney 1
Vdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 89.80 High High
Glutamate receptor 6 86.04 High High
Nerve growth factor 2 83.08 Quite High
member 8 1 72.56 Quite High
Multiple sclerosis 2 55.52 Quite High
agonist 2 36.48 Quite Low
antagonist 2 35.44 Quite Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 4 100.00 Very High Very High Very High
Hypercalcemia 4 97.76 Very High Very High Very High
Drug Induced Neurotoxicity 12 97.12 Very High Very High Very High
Osteoporosis 3 94.96 High High
Rickets 2 90.84 High High
Bone Cancer 2 90.32 High High
Genetic Predisposition To Disease 2 88.56 High High
Sunburn 2 66.00 Quite High
Cancer 2 58.72 Quite High
Diabetes Mellitus 4 57.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia.
vitamin D receptor Binding (ligand) of associated with hypercalcemia
1) Confidence 0.31 Published 2010 Journal J. Bone Miner. Res. Section Title Doc Link 20200930 Disease Relevance 0.34 Pain Relevance 0.07
-aminolevulinic acid dehydratase; the vitamin D receptor (VDR) gene; and the hemochromatosis gene coding for a defective protein known as HFE.
vitamin D receptor Binding (coding) of associated with iron overload
2) Confidence 0.30 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247191 Disease Relevance 0.61 Pain Relevance 0.08
-aminolevulinic acid dehydratase; the vitamin D receptor (VDR) gene; and the hemochromatosis gene coding for a defective protein known as HFE.
VDR Binding (coding) of associated with iron overload
3) Confidence 0.30 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247191 Disease Relevance 0.61 Pain Relevance 0.08
Once vitamin D is absorbed from the diet or made in the skin by the action of sunlight, it is metabolized in the liver to 25-hydroxyvitamin D [25(OH)D] and then in the kidney to 1,25-dihydroxyvitamin D [1,25(OH)2D]. 1,25(OH)2D interacts with its nuclear receptor (VDR) in the intestine and bone in order to maintain calcium homeostasis.
VDR Binding (interacts) of in kidney
4) Confidence 0.26 Published 2003 Journal Recent Results Cancer Res. Section Abstract Doc Link 12899511 Disease Relevance 0.32 Pain Relevance 0.09
The VDR is also present in a wide variety of other tissues. 1,25(OH)2D interacts with these receptors to have a multitude of important physiological effects.
VDR Binding (interacts) of
5) Confidence 0.19 Published 2003 Journal Recent Results Cancer Res. Section Abstract Doc Link 12899511 Disease Relevance 0.55 Pain Relevance 0.11

General Comments

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