INT112255

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rgs9) nucleus (Rgs9) cytoplasm (Rgs9)
signal transducer activity (Rgs9)
Anatomy Link Frequency
gray matter 1
Rgs9 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 2 99.74 Very High Very High Very High
Morphine 10 99.54 Very High Very High Very High
mu opioid receptor 3 98.04 Very High Very High Very High
Thalamus 3 97.92 Very High Very High Very High
Central grey 1 97.52 Very High Very High Very High
agonist 3 97.12 Very High Very High Very High
Enkephalin 2 96.24 Very High Very High Very High
antinociception 1 93.44 High High
Potency 1 92.68 High High
Analgesic 5 92.08 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The duration of morphine analgesia was greatly increased in RGS9-2 and in RGS11 knockdown mice.
Positive_regulation (increased) of RGS9-2 associated with analgesia and morphine
1) Confidence 0.54 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12902995 Disease Relevance 0 Pain Relevance 1.18
At 2 days after commencing sustained morphine treatment, the levels of mRNA for RGS7, RGS9-2, RGS11, and Gbeta5 increased in most of the brain structures studied (striatum, thalamus, periaqueductal gray matter (PAG), and cortex).
Positive_regulation (increased) of RGS9-2 in gray matter associated with urological neuroanatomy, thalamus, central grey and morphine
2) Confidence 0.37 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0.35 Pain Relevance 1.08

General Comments

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