INT112267

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.10
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Rgc32) cytoskeleton (Rgc32) nucleus (Rgc32)
cell cycle (Rgc32) microtubule organizing center (Rgc32) cytoplasm (Rgc32)
Anatomy Link Frequency
retinal ganglion cell 3
optic nerve 1
Rgc32 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Versed 2 99.14 Very High Very High Very High
ketamine 6 97.22 Very High Very High Very High
Buprenorphine 2 96.26 Very High Very High Very High
Neuritis 2 93.56 High High
imagery 41 88.60 High High
ischemia 25 87.32 High High
Glutamate 110 85.44 High High
antagonist 24 83.96 Quite High
Multiple sclerosis 3 83.72 Quite High
anesthesia 11 82.68 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 32 100.00 Very High Very High Very High
Injury 20 99.98 Very High Very High Very High
Apoptosis 159 99.96 Very High Very High Very High
Death 62 99.96 Very High Very High Very High
Glaucoma 248 99.82 Very High Very High Very High
Multiple Sclerosis 7 99.12 Very High Very High Very High
Targeted Disruption 8 95.28 Very High Very High Very High
Neurodegenerative Disease 13 95.08 Very High Very High Very High
Stroke 44 94.56 High High
Optic Nerve Injuries 126 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The addition of carprofen to chloral hydrate did not affect RGC numbers (382.7 +/- 15.2 RGCs/mm(2); n.s.), while chloral hydrate with buprenorphine (421.1 +/- 25.1 RGCs/mm(2); p < 0.05), ketamine and xylazine (403.6 +/- 36.1 RGCs/mm(2); p < 0.05), or fentanyl with medetomidine and midazolam (481.3 +/- 10.4 RGCs/mm(2); p < 0.05) all increased RGC survival.
Positive_regulation (increased) of RGC in RGCs associated with versed, ketamine and buprenorphine
1) Confidence 0.39 Published 2004 Journal J. Neurotrauma Section Abstract Doc Link 14987467 Disease Relevance 0.13 Pain Relevance 0.62
Methylprednisolone treatment significantly increased RGC apoptosis during MOG-EAE.
Positive_regulation (increased) of RGC associated with multiple sclerosis and apoptosis
2) Confidence 0.28 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12904460 Disease Relevance 1.37 Pain Relevance 0.45
A classic model to study injury-induced RGC death involves optic nerve lesions in the albino rat.
Positive_regulation (induced) of RGC in optic nerve associated with injury and death
3) Confidence 0.10 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.96 Pain Relevance 0.04
Relatively increased RGC numbers were seen centrally, closer to the ON (Figure 2A).
Positive_regulation (increased) of RGC
4) Confidence 0.09 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185481 Disease Relevance 0.67 Pain Relevance 0
In adult Sprague-Dawley (SD, albino) and Piebald-Viral-Glaxo (PVG, pigmented) rats, the left optic nerve was transected intraorbitally to induce retinal ganglion cell (RGC) death.
Positive_regulation (induce) of RGC in retinal ganglion cell associated with ganglion cysts and death
5) Confidence 0.09 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2779069 Disease Relevance 0.53 Pain Relevance 0
Application of memantine significantly increased RGC survival in experimental rat glaucoma (WoldeMussie et al., 2002), and a similar result was reported using the DBA/2J transgenic mouse model of glaucoma (Schuettauf et al., 2002).
Positive_regulation (increased) of RGC associated with targeted disruption and glaucoma
6) Confidence 0.08 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 0.92 Pain Relevance 0.34
Post-rAION, there is no significant increase in RGC numbers in estrogen treated animals compared with vehicle-treated controls.
Neg (no) Positive_regulation (increase) of RGC in RGC
7) Confidence 0.05 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2185481 Disease Relevance 0.79 Pain Relevance 0.10
deposition in experimental glaucoma and its induction of RGC apoptosis in vivo suggests that A?
Positive_regulation (induction) of RGC associated with glaucoma and apoptosis
8) Confidence 0.05 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.20 Pain Relevance 0.04
Assessment of the SSP model with DARC has shown that it generates rapid and extensive RGC apoptosis with peak levels visualized at 2 h in the rat, and is a useful tool in the assessment of neuroprotective strategies, with strong data attainable within a relatively short time (Cordeiro et al., 2004; Guo et al., 2006).


Positive_regulation (generates) of RGC associated with apoptosis
9) Confidence 0.05 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 0.59 Pain Relevance 0.26
An example of a neuroprotective vaccine is R16, a peptide (interphotoreceptor-retinoid binding protein) derived from the RGC.[100]

STAT-3 activation

Positive_regulation (activation) of RGC
10) Confidence 0.01 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792620 Disease Relevance 0.93 Pain Relevance 0.24

General Comments

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