INT112270

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.74
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cntnap1) cell adhesion (Cntnap1) cytoskeleton organization (Cntnap1)
Anatomy Link Frequency
corpus callosum 2
Cortical bone 1
node 1
Cntnap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.6 25 99.80 Very High Very High Very High
Nav1.2 2 89.72 High High
Multiple sclerosis 56 87.32 High High
sodium channel 3 84.24 Quite High
Demyelination 52 82.96 Quite High
Spinal cord 36 80.00 Quite High
potassium channel 3 56.88 Quite High
Action potential 58 5.00 Very Low Very Low Very Low
Inflammation 40 5.00 Very Low Very Low Very Low
Dorsal column 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 434 99.96 Very High Very High Very High
Demyelinating Disease 118 87.32 High High
Congenital Anomalies 11 80.80 Quite High
Alzheimer's Dementia 20 53.72 Quite High
Pressure And Volume Under Development 4 45.56 Quite Low
Endometriosis (extended) 30 12.96 Low Low
Disease 56 5.00 Very Low Very Low Very Low
INFLAMMATION 42 5.00 Very Low Very Low Very Low
Body Weight 11 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate these roles, we characterized node development in mice deficient in contactin-associated protein (Caspr), an integral junctional component.
Negative_regulation (deficient) of Caspr in node
1) Confidence 0.57 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12904461 Disease Relevance 0.08 Pain Relevance 0.48
Cortical bone area and volume at the midshaft was also significantly decreased in OVX mice compared to SHM, whereas other treatment groups were not.

3.12.

Negative_regulation (decreased) of SHM in Cortical bone
2) Confidence 0.31 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951124 Disease Relevance 0 Pain Relevance 0
A significant decrease in Caspr and Nav1.6 staining occurred in the corpus callosum of vehicle-treated EAE mice.
Negative_regulation (decrease) of Caspr in corpus callosum associated with multiple sclerosis and nav1.6
3) Confidence 0.13 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.73 Pain Relevance 0.82
During chronic EAE, Caspr staining levels were decreased significantly to <60% of normal corpus callosum (Fig. 7B).
Negative_regulation (decreased) of Caspr in corpus callosum associated with multiple sclerosis
4) Confidence 0.13 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.92 Pain Relevance 0.46

General Comments

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