INT112278

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
motoneurons 6
endothelial cells 1
brain 1
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 5 72.56 Quite High
nMDA receptor 5 65.12 Quite High
Neuronal nitric oxide synthase 3 61.16 Quite High
Central nervous system 2 56.04 Quite High
Sciatica 9 25.00 Low Low
ketamine 2 15.92 Low Low
Hippocampus 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 6 92.00 High High
Injury 6 85.64 High High
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Endometriosis (extended) 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Positive_regulation (regulation) of Regulation (regulation) of nNOS in motoneurons
1) Confidence 0.38 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Positive_regulation (-) of Regulation (regulation) of nNOS in motoneurons
2) Confidence 0.38 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03
Our results provide in vivo evidence that the survival of injured adult mammalian motoneurons can be promoted by specific neurotrophic factors, and that this effect is associated with inhibition of nNOS expression and up-regulation of c-Jun and P75 expression.
Positive_regulation (up) of Regulation (regulation) of nNOS in motoneurons
3) Confidence 0.38 Published 2003 Journal J. Neurotrauma Section Abstract Doc Link 12906744 Disease Relevance 0.33 Pain Relevance 0.03
However, the exact mechanism is still unknown.9 It has been well documented that estrogen influences the NO system in both peripheral and nervous tissues.10-12 Additionally, estrogen increases eNOS activity and expression13,14 as well as the production of nitric oxide in endothelial cells.15 Estrogen alters nNOS mRNA regulation, the number of nNOS-expressing neurons and NO production in the brain.16,17
Positive_regulation (oxide) of in endothelial cells Regulation (regulation) of nNOS in brain
4) Confidence 0.36 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2933129 Disease Relevance 0 Pain Relevance 0.16

General Comments

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