INT1123

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 74
Total Number 74
Disease Relevance 51.96
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD79A)
Anatomy Link Frequency
blood 3
erythrocyte 2
plasma cells 2
gut 2
stomach 2
CD79A (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 89 99.84 Very High Very High Very High
Pain 57 99.84 Very High Very High Very High
Angina 8 99.84 Very High Very High Very High
cINOD 26 99.76 Very High Very High Very High
spinal inflammation 86 99.56 Very High Very High Very High
rheumatoid arthritis 177 98.96 Very High Very High Very High
abdominal pain 33 97.76 Very High Very High Very High
intrathecal 22 97.68 Very High Very High Very High
headache 61 97.20 Very High Very High Very High
Inflammation 361 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bullous Skin Disease 10 100.00 Very High Very High Very High
Thrombocytopenia 9 99.96 Very High Very High Very High
Leukocytosis 3 99.96 Very High Very High Very High
Brucella Infection 12 99.92 Very High Very High Very High
Multiple Sclerosis 94 99.84 Very High Very High Very High
Pain 45 99.84 Very High Very High Very High
Cv General 3 Under Development 13 99.84 Very High Very High Very High
Purpura 10 99.84 Very High Very High Very High
Serum Sickness 13 99.80 Very High Very High Very High
Vasculitis 22 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Laboratory examination on admission showed an increase of serum IgA level, a presence of immune complex, remarkable hematuria (grade III) and proteinuria (grade II).
Positive_regulation (increase) of IgA associated with proteinuria and hematuria
1) Confidence 0.70 Published 1998 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 9884550 Disease Relevance 1.05 Pain Relevance 0.09
By immunohistochemistry the lymphoplasmacellular infiltrate showed polyclonal expression of IgA without IgA increase in serum, urine and duodenal juice.
Neg (without) Positive_regulation (increase) of IgA in urine
2) Confidence 0.70 Published 1991 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 1874129 Disease Relevance 0.59 Pain Relevance 0.12
Positive_regulation (eased. Pa) of IgA
3) Confidence 0.69 Published 1990 Journal Nephron Section Title Doc Link 2404214 Disease Relevance 1.84 Pain Relevance 0.09
Polyclonal elevation of IgA and IgG in serum was found, along with cryoglobulins containing IgA and IgG (rheumatoid factor positive).
Positive_regulation (elevation) of IgA
4) Confidence 0.69 Published 1978 Journal Am. J. Med. Sci. Section Abstract Doc Link 153712 Disease Relevance 0.87 Pain Relevance 0.10
Laboratory examinations showed increased serum IgA level and renal dysfunction gradually progressed.
Positive_regulation (increased) of IgA associated with renal disease
5) Confidence 0.67 Published 2010 Journal Rinsho Ketsueki Section Abstract Doc Link 20467223 Disease Relevance 0.76 Pain Relevance 0.12
It is suggested that if there is evidence of recent group a streptococcal infection, the conditions for diagnosis of RARF are as follows: 1) When one major or more than two minor criteria are present in a patient with RHD, a definite diagnosis of RARF may be made. 2) A presumptive diagnosis of RARF may be made, when a patient presents one minor criteria and several other manifestations such as anemia, abdominal pain, rapid sleeping pulse rate, tachycardia out of proportion to fever, malaise, epistaxis, precordial pain and an elevated level of IgG, IgA, C3 and circulating immune complexes.
Positive_regulation (elevated) of IgA associated with rheumatic fever, pain, nose bleeds, heart rate under development, abdominal pain, streptococcal infections, fever, rheumatic heart disease and anaemia
6) Confidence 0.67 Published 1995 Journal Zhonghua Nei Ke Za Zhi Section Abstract Doc Link 8731832 Disease Relevance 1.47 Pain Relevance 0.20
The significance of IgA deposition in the mesangium, and of an increase in the serum levels of IgA in some patients with A Sp is unclear.
Positive_regulation (increase) of IgA in mesangium
7) Confidence 0.67 Published 1980 Journal Nephron Section Abstract Doc Link 6448964 Disease Relevance 0.34 Pain Relevance 0.16
The activity of the non-T cell fraction was slightly but not significantly reduced in patients with high disease activity (CRP greater than 0.01 g/l) compared with normal controls, (14.6 +/- 2.8 g/l versus 20.4 +/- 2.4 g/l mean +/- SE; p less than 0.10) Serum IgG and IgA concentrations were increased (p less than 0.001 and p less than 0.05 respectively) Interferon caused normal augmentation in the NK cell activity in AS patients, and no correlation was found between serum gamma interferon titres and the NK cell activity.
Positive_regulation (increased) of IgA in NK cell associated with disease
8) Confidence 0.67 Published 1984 Journal Scand. J. Rheumatol. Section Abstract Doc Link 6441246 Disease Relevance 0.54 Pain Relevance 0.14
RESULTS: IgA anti-Klebsiella antibody titers were elevated in AS and HLA-B27 negative AAU compared to the HLA-B27 positive and negative controls or patients with active RA (p < 0.001).
Positive_regulation (elevated) of IgA
9) Confidence 0.67 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9558179 Disease Relevance 0.25 Pain Relevance 0
Isolated elevation of IgA anti-beta2glycoprotein I antibodies with manifestations of antiphospholipid syndrome: a case series of five patients.
Positive_regulation (elevation) of IgA associated with anti-phospholipid antibody syndrome
10) Confidence 0.67 Published 2009 Journal Lupus Section Title Doc Link 19762404 Disease Relevance 0.90 Pain Relevance 0.18
This case series supports that elevated IgA anti-beta(2)GPI antibody titres may identify additional patients who have clinical features of APS but who do not meet current diagnostic criteria.
Positive_regulation (elevated) of IgA associated with anti-phospholipid antibody syndrome
11) Confidence 0.67 Published 2009 Journal Lupus Section Abstract Doc Link 19762404 Disease Relevance 0.97 Pain Relevance 0.19
Moreover, correlations were found between blood pressure responses and task related cortisol activity and between baseline blood pressure levels and task-induced S-IgA levels.
Positive_regulation (induced) of S-IgA in blood
12) Confidence 0.63 Published 2005 Journal Biol Psychol Section Abstract Doc Link 16038773 Disease Relevance 0.25 Pain Relevance 0
Physical examination revealed hepatosplenomegaly, in laboratory tests leukopenia, mild thrombocytopenia, elevated ESR, elevated serum levels of IgG, IgM, IgA, creatine kinase level and hypergammaglobulinaemia were found.
Positive_regulation (elevated) of IgA associated with leukopenia and thrombocytopenia
13) Confidence 0.52 Published 2005 Journal Prz. Lek. Section Abstract Doc Link 16334539 Disease Relevance 1.06 Pain Relevance 0.12
There was no significant increase in BAL IgA.
Neg (no) Positive_regulation (increase) of BAL IgA
14) Confidence 0.50 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0 Pain Relevance 0
METHODS: Using ELISA, we estimated serum IgG and IgA antigliadin antibodies in 147 neurological patients who were divided into two groups.
Positive_regulation (estimated) of IgA
15) Confidence 0.49 Published 1996 Journal Lancet Section Body Doc Link 8598704 Disease Relevance 0.19 Pain Relevance 0
The elevated IgA antigliadin titre in the RA group might be ascribed to the use of NSAIDs, which are harmful to the gut, but the immunological trigger effect of gluten cannot be ruled out.
Positive_regulation (elevated) of IgA in gut associated with cinod and rheumatoid arthritis
16) Confidence 0.49 Published 1989 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 2612082 Disease Relevance 1.13 Pain Relevance 0.80
Low levels of IgA complexes were a consistent finding and were significantly lower in the HLA Cw7 group.
Positive_regulation (levels) of IgA
17) Confidence 0.49 Published 1988 Journal Arch Otorhinolaryngol Section Abstract Doc Link 3245800 Disease Relevance 0.26 Pain Relevance 0.09
ELISA allowed the determination of brucella-specific immunoglobulins (Ig)G, IgM and IgA in the CSF, and provided profiles of Ig, in sera, which were different in patients with chronic (elevated IgG and IgA) from those with acute (elevated IgM alone or IgG, IgM and IgA) brucellosis.
Positive_regulation (elevated) of IgA associated with brucella infection
18) Confidence 0.48 Published 1988 Journal Q. J. Med. Section Abstract Doc Link 3051080 Disease Relevance 1.27 Pain Relevance 0.14
In 6 patients the elevated IgA titers were sustained even at 3 months after the episode of AMI.
Positive_regulation (elevated) of IgA associated with myocardial infarction
19) Confidence 0.48 Published 2000 Journal Jpn. Circ. J. Section Abstract Doc Link 11110424 Disease Relevance 1.67 Pain Relevance 0.55
In serum samples from 125 controls with 4 different chronic diseases (systemic lupus erythematosus, ankylosing spondylitis, bronchial asthma, and polyarteritis nodosa), levels of IgA-, IgA1-, and IgA2-RF were found to be increased in 7%, 7%, and 8%, respectively.
Positive_regulation (increased) of IgA associated with asthma, spinal inflammation, vasculitis, systemic lupus erythematosus and chronic disease
20) Confidence 0.47 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.91 Pain Relevance 0.27

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