INT11230

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1987
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 23
Total Number 32
Disease Relevance 19.54
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MUC16) extracellular region (MUC16) cell adhesion (MUC16)
plasma membrane (MUC16)
Anatomy Link Frequency
uterine 2
plasma 1
blood 1
liver 1
MUC16 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 30 99.96 Very High Very High Very High
Inflammation 7 99.46 Very High Very High Very High
Dismenorea 26 99.00 Very High Very High Very High
cytokine 13 98.24 Very High Very High Very High
pain pelvic 7 97.12 Very High Very High Very High
Chronic pancreatitis 6 95.64 Very High Very High Very High
palliative 4 86.32 High High
anesthesia 5 62.80 Quite High
abdominal pain 3 53.84 Quite High
headache 3 52.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 217 100.00 Very High Very High Very High
Endometriosis (extended) 24 99.96 Very High Very High Very High
Pancreatitis 9 99.88 Very High Very High Very High
Endometriosis 10 99.72 Very High Very High Very High
Neuroendocrine Cancer 1 99.56 Very High Very High Very High
Pancreatic Cancer 13 99.52 Very High Very High Very High
Ovarian Cancer 479 99.48 Very High Very High Very High
INFLAMMATION 8 99.46 Very High Very High Very High
Recurrence 25 99.24 Very High Very High Very High
Dysmenorrhea 14 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of hysterectomy on serum CA 125 levels in patients with adenomyosis and uterine fibroids.
Regulation (effect) of CA 125 in uterine associated with uterine fibroids and dismenorea
1) Confidence 0.60 Published 1987 Journal Hum. Reprod. Section Title Doc Link 3474239 Disease Relevance 0.64 Pain Relevance 0.47
Serum CA 125 levels in patients with endometriosis: changes in CA 125 levels during menstruation.
Regulation (changes) of CA 125 associated with endometriosis
2) Confidence 0.60 Published 1988 Journal Obstet Gynecol Section Title Doc Link 3165507 Disease Relevance 0.63 Pain Relevance 0.37
Whether differential glycosylation affects antibody recognition and/or the function properties of the MUC16 protein is not known currently.
Spec (Whether) Regulation (affects) of MUC16 protein
3) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.95 Pain Relevance 0
Five weeks after the operation the CA 125 levels did not differ from the pre-operative levels.
Neg (not) Regulation (differ) of CA 125
4) Confidence 0.44 Published 1987 Journal Hum. Reprod. Section Abstract Doc Link 3474239 Disease Relevance 0.60 Pain Relevance 0.47
We found that diagnostic laparoscopy or laparoscopic surgical procedures did not change the levels of CA-125 at the 24th hour after laparoscopy indicating either serum CA-125 levels are not correlated, at least within 24 hours, with peritoneal irritation or peritoneal irritation is minimal or absent in our operations.
Neg (not) Regulation (change) of CA-125
5) Confidence 0.44 Published 2004 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 15493182 Disease Relevance 0.33 Pain Relevance 0.16
We found that laparotomy for hysterectomy did not change the levels of CA-125 at the 24th hour after the operation, indicating either serum CA-125 levels are not correlated, at least within 24 hours, with peritoneal irritation or peritoneal irritation was minimal or absent in our operations.
Neg (not) Regulation (change) of CA-125
6) Confidence 0.44 Published 2004 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 15597853 Disease Relevance 0.25 Pain Relevance 0.08
The data from the study showed that early CA125 change during the first chemotherapy course and CA125 before the second chemotherapy course were strongly correlated with survival [36].
Regulation (change) of CA125
7) Confidence 0.38 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.23 Pain Relevance 0
The key difference between our study and those mentioned above revolves around the method of calculating CA125 improvements or deterioration over time.
Regulation (calculating) of CA125
8) Confidence 0.38 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.24 Pain Relevance 0
However, the performance of the best two marker combination (MUC16 and WFDC2) was not significantly different from the best single marker (MUC16) as measured by pAUC (from specificity?
Neg (not) Regulation (different) of MUC16
9) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440813 Disease Relevance 0.16 Pain Relevance 0
The aim of the study was to investigate the clinical value of the serum CA 125 level for diagnosing and determining the severity of endometriosis and pelvic pain associated with endometriosis.
Spec (investigate) Regulation (value) of CA 125 associated with endometriosis and pain pelvic
10) Confidence 0.26 Published 2007 Journal Int. J. Biol. Markers Section Abstract Doc Link 17922463 Disease Relevance 0.79 Pain Relevance 0.53
Prognostic value of CA 125 in advanced ovarian cancer.
Regulation (value) of CA 125 associated with ovarian cancer
11) Confidence 0.26 Published 1992 Journal Gynecol. Oncol. Section Title Doc Link 1541430 Disease Relevance 0.32 Pain Relevance 0.05
CA 19-9, CYFRA 21-1 and CA 15-3 gave the most considerable contributions to the classification system, whereas CEA, CA 125, CA 72-4, AFP, liver enzymes, lipase, amylase, bilirubin, and ferritin were of no or little value.
Neg (little) Regulation (value) of CA 125 in liver
12) Confidence 0.26 Published 2000 Journal Anticancer Res. Section Body Doc Link 11326646 Disease Relevance 0.21 Pain Relevance 0
CA 19-9 permits differential diagnosis from neuroendocrine tumor or pancreatitis, the values of CA 125 and CEA are useful in the evaluation of the stage, resectability and prognosis of pancreatic cancer.
Regulation (values) of CA 125 associated with neuroendocrine cancer, pancreatic cancer and pancreatitis
13) Confidence 0.26 Published 1999 Journal Tumori Section Abstract Doc Link 10235075 Disease Relevance 0.84 Pain Relevance 0.07
CEA and CA 125 are not as sensitive markers of PC as CA 19-9, while CEA and CA 125 serum levels are both increased in half of the patients with chronic pancreatitis.
Regulation (sensitive) of CA 125 associated with pancreatic cancer and chronic pancreatitis
14) Confidence 0.26 Published 1997 Journal Acta Chir Hung Section Abstract Doc Link 9408313 Disease Relevance 1.38 Pain Relevance 0.50
Predictive value of CA 125 during early chemotherapy of advanced ovarian cancer.
Regulation (value) of CA 125 associated with ovarian cancer
15) Confidence 0.26 Published 1990 Journal Gynecol. Oncol. Section Title Doc Link 2323611 Disease Relevance 0.63 Pain Relevance 0.06
In women without endometriosis, such cyclic changes of CA 125 in plasma are not observed.
Regulation (changes) of CA 125 in plasma associated with endometriosis
16) Confidence 0.26 Published 1993 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 8365504 Disease Relevance 0.73 Pain Relevance 0.24
We investigated the prognostic impact of changes in serum CA125 levels during the first 3 months of therapy in ovarian cancer.


Spec (investigated) Regulation (changes) of CA125 associated with ovarian cancer
17) Confidence 0.26 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2959041 Disease Relevance 0.43 Pain Relevance 0
Changes in CA125 were classified into six groups.
Regulation (Changes) of CA125
18) Confidence 0.26 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2959041 Disease Relevance 0.30 Pain Relevance 0
The catheter and/or endogenous cytokines produced in response to treatment might produce inflammatory effects of treatment that affect systemic CA125 levels.
Regulation (affect) of CA125 associated with inflammation and cytokine
19) Confidence 0.26 Published 2007 Journal J Transl Med Section Body Doc Link PMC2248163 Disease Relevance 0.60 Pain Relevance 0.13
BACKGROUND: To estimate the value of CA-125 for the diagnosis of endometriosis in women with dysmenorrhea, as well as its significance in monitoring therapy and follow-up.
Regulation (value) of CA-125 associated with endometriosis and dismenorea
20) Confidence 0.23 Published 1998 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 9688246 Disease Relevance 0.50 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox