INT112312

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 2003
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.23
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
mast cells 1
tryptase (Mus musculus)
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 2 95.72 Very High Very High Very High
agonist 7 92.40 High High
antagonist 4 89.08 High High
neuropeptide release 2 87.92 High High
Neuropeptide 2 86.04 High High
Visceral pain 1 83.28 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 83.28 Quite High
Hypersensitivity 3 75.44 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

7 75.00 Quite High
Diarrhoea 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the gastrointestinal tract, PAR-2 may be activated by tryptase from mast cells but also by luminal proteases such as trypsin and possibly bacterial proteases.
tryptase Spec (may) Positive_regulation (activated) of PAR-2 in mast cells
1) Confidence 0.08 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924448 Disease Relevance 0.08 Pain Relevance 0.12
These results demonstrate the potential involvement of tryptase-mediated activation of PAR-2 in promoting airway hyperresponsiveness.
tryptase Positive_regulation (activation) of PAR-2
2) Confidence 0.00 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12907252 Disease Relevance 0 Pain Relevance 0.37
In this study, we have investigated the potential role of tryptase-mediated activation of proteinase-activated receptor-2 (PAR-2) in promoting airway hyperresponsiveness.
tryptase Spec (investigated) Positive_regulation (activation) of PAR-2
3) Confidence 0.00 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12907252 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox