INT112327

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.64
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FSHB) small molecule metabolic process (FSHB) extracellular region (FSHB)
cellular nitrogen compound metabolic process (FSHB) cytoplasm (FSHB)
Anatomy Link Frequency
Sertoli cell 6
testis 2
FSHB (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 4 97.12 Very High Very High Very High
corticosteroid 1 77.32 Quite High
agonist 6 75.00 Quite High
fibrosis 4 62.92 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 154 99.78 Very High Very High Very High
Vomiting 1 97.64 Very High Very High Very High
Headache 4 97.12 Very High Very High Very High
Adenoma 162 89.20 High High
Hypopituitarism 4 86.88 High High
Diabetes Insipidus 1 75.24 Quite High
Pituitary Apoplexy 2 75.00 Quite High
Stroke 1 75.00 Quite High
Sprains And Strains 4 66.56 Quite High
Emergencies 1 65.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hormone testing revealed increased serum levels of FSH and decreased serum levels of LH.
Positive_regulation (increased) of Gene_expression (levels) of FSH
1) Confidence 0.44 Published 2003 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 12910066 Disease Relevance 1.13 Pain Relevance 0.27
Immunohistochemically, the tumor cells are frequently positive for FSH?
Positive_regulation (for) of Gene_expression (positive) of FSH associated with cancer
2) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 1.19 Pain Relevance 0.06
Immunohistochemically, the tumor cells are frequently positive for FSH?
Positive_regulation (frequently) of Gene_expression (positive) of FSH associated with cancer
3) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 1.25 Pain Relevance 0.06
Given that the estradiol treatment clearly elevated circulating FSH concentrations, this observation is consistent with the key role of FSH in Sertoli cell proliferation in mice [27], and with more recent studies where genetic induction of FSH production in hpg mice has increased Sertoli cell production [28].
Positive_regulation (induction) of Gene_expression (production) of FSH in Sertoli cell
4) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Whilst estradiol production acts within the testis to retard early androgen production, it also acts in the pituitary gland to stimulate FSH production and thereby promote early Sertoli cell proliferation.
Positive_regulation (stimulate) of Gene_expression (production) of FSH in Sertoli cell
5) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Given that the estradiol treatment clearly elevated circulating FSH concentrations, this observation is consistent with the key role of FSH in Sertoli cell proliferation in mice [27], and with more recent studies where genetic induction of FSH production in hpg mice has increased Sertoli cell production [28].
Positive_regulation (circulating) of Gene_expression (concentrations) of FSH in Sertoli cell
6) Confidence 0.06 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
The importance of this estrogen-induced increase in FSH secretion is not known: it has not been established whether estradiol acting directly at the level of the testis is sufficient to produce qualitative spermatogenesis in hpg mice or whether the effects of estradiol in inducing spermatogenesis are more indirect, occurring via the rise in FSH production.
Spec (whether) Positive_regulation (occurring) of Gene_expression (production) of FSH in testis
7) Confidence 0.05 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.07 Pain Relevance 0

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