INT112334

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 15.85
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (NF1) signal transduction (NF1) nucleus (NF1)
intracellular (NF1) extracellular matrix organization (NF1) cytoplasm (NF1)
Anatomy Link Frequency
coronary artery 2
blood 1
peripheral nervous system 1
NF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 1 99.80 Very High Very High Very High
cytokine 6 74.16 Quite High
imagery 39 72.08 Quite High
anesthesia 4 60.36 Quite High
isoflurane 1 59.92 Quite High
Spinal cord 3 59.20 Quite High
Waddell signs 2 50.00 Quite Low
Sciatic nerve 15 29.84 Quite Low
Pain 10 10.00 Low Low
Angina 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 878 100.00 Very High Very High Very High
Watson Syndrome 43 100.00 Very High Very High Very High
Neurofibromatosis 27 100.00 Very High Very High Very High
Disease Progression 1 99.68 Very High Very High Very High
Atherosclerosis 84 99.24 Very High Very High Very High
Toxicity 21 98.84 Very High Very High Very High
Cancer 230 97.84 Very High Very High Very High
Hyperplasia 90 97.24 Very High Very High Very High
Pathologic Constriction 72 97.16 Very High Very High Very High
Disease 25 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based upon these observations it may be concluded that at rest, mean WSS is regulated locally and depends on the characteristics of the peripheral circulation.
Regulation (regulated) of WSS associated with stress
1) Confidence 0.52 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.80 Pain Relevance 0
NF1 primarily affects the peripheral nervous system and is often characterized by large numbers of neurofibromas.
Regulation (affects) of NF1 in peripheral nervous system associated with peripheral nervous system, watson syndrome and neurofibroma
2) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2823760 Disease Relevance 1.52 Pain Relevance 0.05
This is a serious limitation, because information about the level of WSS and its direction in arterial bifurcations, especially opposite to flow dividers, is of utmost importance when studying the role of WSS in atherogenesis.
Regulation (direction) of WSS associated with stress and atherosclerosis
3) Confidence 0.38 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.79 Pain Relevance 0
Such underestimations of WSR do not only affect calculated WSS, but also calculated or determined whole blood viscosity, which strongly depends on shear rate (Eq. 2).


Regulation (affect) of WSS in blood associated with stress
4) Confidence 0.38 Published 2008 Journal Med Biol Eng Comput Section Body Doc Link PMC2441533 Disease Relevance 0.65 Pain Relevance 0
Neurofibromatosis type I (NF1) is an autosomal dominant condition affecting
Regulation (affecting) of NF1 associated with neurofibromatosis
5) Confidence 0.27 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC548804 Disease Relevance 0.93 Pain Relevance 0.03
alterations in NF1 led to our hypothesis that pirfenidone might
Regulation (alterations) of NF1
6) Confidence 0.27 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC548804 Disease Relevance 1.01 Pain Relevance 0.07
This noninvasive methodology provides the opportunity to serially quantify changes in WSS during disease progression and/or therapeutic intervention.
Regulation (changes) of WSS associated with stress and disease progression
7) Confidence 0.24 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16714362 Disease Relevance 0.67 Pain Relevance 0.16
Neurofibromatosis type I (NF1) is an autosomal dominant condition affecting
Regulation (affecting) of Neurofibromatosis type I associated with neurofibromatosis
8) Confidence 0.23 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC548804 Disease Relevance 0.93 Pain Relevance 0.03
CONCLUSIONS: Based on the above results, the following conclusions were made: 1) WSs do not correlate with psychological distress; 2) WSs do not discriminate organic from nonorganic problems; 3) WSs may represent an organic phenomenon; 4) WSs are associated with poorer treatment outcome; 5) WSs are associated with greater pain levels; 6) WSs are not associated with secondary gain; and 7) As a group, WS studies demonstrate some methodological problems.


Regulation (associated) of WSs
9) Confidence 0.20 Published 2003 Journal Pain Med Section Body Doc Link 12911018 Disease Relevance 0 Pain Relevance 0
Their interaction is expected to affect the pressure and WSS distributions near the anastomosis.
Regulation (affect) of WSS associated with stress
10) Confidence 0.08 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 0.24 Pain Relevance 0
In contrast, in the end-to-side anastomosis highest WSS values were located in the distal bypass graft close to the anastomosis.
Regulation (values) of WSS associated with stress
11) Confidence 0.05 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 1.12 Pain Relevance 0
We found WSS variations in both types of anastomoses, with highest WSS values at the heel and lowest WSS values at the floor of the end-to-side anastomosis case.
Regulation (values) of WSS associated with stress
12) Confidence 0.05 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 1.34 Pain Relevance 0
The highest WSS values were found during mid-systole (timestep 20) and were located at the heel of the anastomosis and at the side of a nearby clip that was placed during surgery (Figure 5).
Regulation (values) of WSS associated with stress
13) Confidence 0.05 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 0.88 Pain Relevance 0
There were some areas of elevated WSS close to the anastomosis, but the highest WSS values were found in the atherosclerotic distal coronary artery (Figure 8).
Regulation (values) of WSS in coronary artery associated with stress and atherosclerosis
14) Confidence 0.05 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 1.07 Pain Relevance 0
We found WSS variations in both types of anastomoses, with highest WSS values at the heel and lowest WSS values at the floor of the end-to-side anastomosis case.
Regulation (values) of WSS associated with stress
15) Confidence 0.05 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 1.29 Pain Relevance 0
Comparing side-to-side to end-to-side anastomosis, the mean WSS values were lower in the side-to-side anastomosis with a time-averaged value of 0.29 Pa in the perianastomotic region (Figure 7 and 8).
Regulation (values) of WSS associated with stress
16) Confidence 0.05 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 0.70 Pain Relevance 0
Lowest WSS values were found in the native coronary artery proximal to the side-to-side anastomosis.
Regulation (values) of WSS in coronary artery associated with stress
17) Confidence 0.05 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2089073 Disease Relevance 1.11 Pain Relevance 0
WSS variations were found in both anastomoses types, with highest WSS values at the heel and lowest WSS values at the floor of the end-to-side anastomosis.
Regulation (values) of WSS associated with stress
18) Confidence 0.05 Published 2007 Journal Biomed Eng Online Section Abstract Doc Link PMC2089073 Disease Relevance 0.79 Pain Relevance 0

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