INT112336

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.62
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 3 92.48 High High
Pain 1 89.60 High High
palliative 4 86.12 High High
Angina 1 79.20 Quite High
Clonidine 1 75.84 Quite High
agonist 1 73.48 Quite High
guanethidine 1 69.84 Quite High
Inflammation 17 63.36 Quite High
Central nervous system 1 49.20 Quite Low
Neurotransmitter 1 48.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 1 99.28 Very High Very High Very High
Apoptosis 2 99.16 Very High Very High Very High
Cardiovascular Disease 9 98.64 Very High Very High Very High
Coronary Heart Disease 1 97.88 Very High Very High Very High
Cancer 65 97.32 Very High Very High Very High
Myocardial Infarction 2 96.96 Very High Very High Very High
Disease 4 94.36 High High
Adhesions 5 92.72 High High
Breast Cancer 17 91.00 High High
Thrombophilia 2 85.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Livedoid vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity (4G/4G) treated successfully with tissue plasminogen activator.
plasminogen activator inhibitor-1 Binding (associated) of
1) Confidence 0.41 Published 2006 Journal Arch Dermatol Section Title Doc Link 17116837 Disease Relevance 0.50 Pain Relevance 0.09
The results also reinforce the previously reported linkage of PAI-1 to physiological stress.
PAI-1 Binding (linkage) of associated with stress
2) Confidence 0.37 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.29 Pain Relevance 0.24
PAI-1 is now recognized as an essential factor of the host microenvironment that promotes tumor growth, vessel recruitment [9]–[14] and dissemination of tumoral cells to distant organs [15], [16].
PAI-1 Binding (recognized) of associated with cancer
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 1.12 Pain Relevance 0.06
We identified two aptamers, WT-15 and SM-20, that disrupt the interactions between PAI-1 and heparin, as well as PAI-1 and vitronectin, without affecting the antiprotease activity of PAI-1.
PAI-1 Binding (interactions) of
4) Confidence 0.28 Published 2009 Journal Oligonucleotides Section Abstract Doc Link 19284310 Disease Relevance 0.48 Pain Relevance 0.08
Through utilization of combinatorial chemistry techniques, aptamers have been selected that bind to PAI-1 with high affinity and specificity.
PAI-1 Binding (bind) of
5) Confidence 0.28 Published 2009 Journal Oligonucleotides Section Abstract Doc Link 19284310 Disease Relevance 0.47 Pain Relevance 0.08
For this reason, we sought to isolate RNA aptamers that disrupt the interaction between PAI-1 and vitronectin.
PAI-1 Binding (interaction) of
6) Confidence 0.22 Published 2009 Journal Oligonucleotides Section Abstract Doc Link 19284310 Disease Relevance 0.47 Pain Relevance 0.09
We identified two aptamers, WT-15 and SM-20, that disrupt the interactions between PAI-1 and heparin, as well as PAI-1 and vitronectin, without affecting the antiprotease activity of PAI-1.
PAI-1 Binding (interactions) of
7) Confidence 0.22 Published 2009 Journal Oligonucleotides Section Abstract Doc Link 19284310 Disease Relevance 0.47 Pain Relevance 0.08
Lack of association of the plasminogen activator inhibitor-1 4G/5G promoter polymorphism with cardiovascular disease in the elderly.
plasminogen activator inhibitor-1 Binding (association) of associated with cardiovascular disease
8) Confidence 0.10 Published 2003 Journal J. Thromb. Haemost. Section Title Doc Link 12911596 Disease Relevance 0.81 Pain Relevance 0.08

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