INT112338

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 9.51
Pain Relevance 17.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
RVM 5
spinal 2
neurons 2
brain 1
GABAergic neurons 1
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 205 100.00 Very High Very High Very High
Central grey 131 100.00 Very High Very High Very High
Glutamate 36 100.00 Very High Very High Very High
Dorsal horn 28 100.00 Very High Very High Very High
5HT 16 100.00 Very High Very High Very High
Rostroventromedial medulla 8 100.00 Very High Very High Very High
gABA 7 99.96 Very High Very High Very High
Serotonin 7 99.84 Very High Very High Very High
Neurotransmitter 4 99.74 Very High Very High Very High
qutenza 61 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 183 100.00 Very High Very High Very High
Nociception 72 99.40 Very High Very High Very High
Pain 175 98.32 Very High Very High Very High
Hyperalgesia 44 97.38 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 96.80 Very High Very High Very High
Stress 3 96.80 Very High Very High Very High
Nervous System Injury 59 93.52 High High
INFLAMMATION 48 86.88 High High
Neuropathic Pain 60 84.48 Quite High
Sleep Disorders 1 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used in vivo microdialysis in awake rats to test the hypothesis that intravenous morphine increases serotonin (5-HT) release within the rostral ventromedial medulla (RVM).
Localization (release) of RVM in RVM associated with serotonin, rostral ventromedial medulla and morphine
1) Confidence 0.31 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12911621 Disease Relevance 0.33 Pain Relevance 1.32
We demonstrated that chronic restraint stress induced thermal hyperalgesia in rats, in which phosphorylated ERK and levels of tryptophan hydroxylase, a key enzyme of 5-HT production, were increased in the RVM. 5HT released from the bulbospinal neurons may exert facilitatory effects on spinal nociceptive processing probably through 5HT3 receptors.
Localization (released) of RVM in spinal associated with nociception, stress, rostroventromedial medulla, thermal hyperalgesia and 5ht
2) Confidence 0.27 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411707 Disease Relevance 1.29 Pain Relevance 1.31
One suggestion is through a connection between the PAG and the RVM known to release brain-derived neurotrophic factor (BDNF).
Localization (release) of RVM in brain associated with urological neuroanatomy and rostral ventromedial medulla
3) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.22 Pain Relevance 1.10
We examined in rats the effect of intra-ventrolateral (VL)-PAG injections of TRPV1 agonists and antagonists on the nocifensive response to heat in the plantar test, neurotransmitter (glutamate and GABA) release in the RVM, and spontaneous and tail flick-related activities of RVM neurons.
Localization (release) of RVM in neurons associated with tail-flick, central grey, rostral ventromedial medulla, neurotransmitter, glutamate, gaba, antagonist and agonist
4) Confidence 0.22 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077685 Disease Relevance 0.66 Pain Relevance 1.52
Intra-VL PAG capsaicin evoked a robust release of glutamate in RVM microdialysates.
Localization (release) of RVM in RVM associated with glutamate, qutenza, central grey and rostral ventromedial medulla
5) Confidence 0.22 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077685 Disease Relevance 0.89 Pain Relevance 2.16
Although 5-HT-containing neurons in the rostral ventromedial medulla (RVM) provide the major descending serotonergic projection to the spinal cord, it is not clear whether the neurotransmitter 5-HT itself released from RVM-spinal neurons contributes to descending pain modulation.
Localization (released) of RVM in medulla associated with pain, neurotransmitter, spinal cord and rostral ventromedial medulla
6) Confidence 0.17 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20573908 Disease Relevance 0.58 Pain Relevance 0.88
We found that the TRPV1 agonist, capsaicin, and the mu-receptor agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin, when coadministered into the ventrolateral-PAG at doses nonanalgesic per se, produce 1) antinociception in tests of thermal nociception; 2) stimulation of glutamate release into the RVM; and 3) inhibition of on neuron activity in the RVM.
Localization (release) of RVM in neuron associated with nociception, qutenza, enkephalin, rostral ventromedial medulla, antinociception, glutamate, agonist and urological neuroanatomy
7) Confidence 0.15 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19297510 Disease Relevance 0.85 Pain Relevance 1.62
These findings suggest that mu-receptor activation not only acts on inhibitory neurons to disinhibit PAG output neurons but also interacts with TRPV1 activation at increasing glutamate release into the RVM, possibly by acting directly on PAG output neurons projecting to the RVM.
Localization (release) of RVM in RVM associated with glutamate, urological neuroanatomy and rostral ventromedial medulla
8) Confidence 0.14 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19297510 Disease Relevance 0.64 Pain Relevance 1.33
The localization of TRPV1 in VL-PAG and RVM neurons was examined using various markers of glutamatergic and GABAergic neurons.
Spec (examined) Localization (localization) of RVM in GABAergic neurons associated with gabaergic, central grey and rostral ventromedial medulla
9) Confidence 0.12 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077685 Disease Relevance 0.75 Pain Relevance 1.76
Blockade of TRPV1 receptors by I-RTX prevented capsaicin-induced antinociception and the increase in RVM glutamate release.
Localization (release) of RVM associated with antinociception, glutamate, qutenza and rostral ventromedial medulla
10) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 1.03 Pain Relevance 1.61
Similarly, i.t. or intra-rostroventromedial medulla (RVM) administration of both selective NTS2 analogs, levocabastine and ?
Localization (administration) of RVM in medulla associated with rostroventromedial medulla
11) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 0.07 Pain Relevance 1.00
PAG and its descending projections to the RVM and dorsal horn of the spinal
Localization (dorsal horn) of RVM in spinal associated with dorsal horn, central grey and rostral ventromedial medulla
12) Confidence 0.07 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 0.98 Pain Relevance 2.01

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