INT112340

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 21
Disease Relevance 5.19
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp11a1)
Anatomy Link Frequency
cleavage 7
spinal 2
skin 2
placenta 2
sciatic nerve 1
Cyp11a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 24 99.64 Very High Very High Very High
Sciatic nerve 3 99.38 Very High Very High Very High
Neuropathic pain 9 98.24 Very High Very High Very High
Spinal cord 12 98.20 Very High Very High Very High
Dorsal horn 10 98.00 Very High Very High Very High
adenocard 10 97.86 Very High Very High Very High
Opioid 1 94.68 High High
Somatosensory cortex 2 86.48 High High
Neurotransmitter 6 82.04 Quite High
tolerance 2 70.56 Quite High
Disease Link Frequency Relevance Heat
Pain 22 99.64 Very High Very High Very High
Disease 37 98.92 Very High Very High Very High
Nociception 7 98.88 Very High Very High Very High
Neuropathic Pain 13 98.24 Very High Very High Very High
Skin Cancer 54 96.56 Very High Very High Very High
Autoimmune Hepatitis 169 93.16 High High
Apoptosis 2 91.28 High High
Liver Disease 9 90.84 High High
Pulmonary Disease 5 90.68 High High
Muscular Spasm 5 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The P450scc gene was over-expressed in spinal and supra-spinal networks during neuropathic pain provoked by sciatic nerve ligature.
Gene_expression (expressed) of P450scc in spinal associated with neuropathic pain and sciatic nerve
1) Confidence 0.77 Published 2004 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 15338057 Disease Relevance 0.49 Pain Relevance 0.63
To determine whether neurosteroidogenesis might be involved in the pivotal role played by the DH in nociception, effects of neurogenic pain provoked by sciatic nerve ligature were investigated on P450scc expression, cellular distribution, and activity in the SC.
Spec (investigated) Gene_expression (expression) of P450scc in sciatic nerve associated with nociception, pain, dorsal horn, sciatic nerve and spinal cord
2) Confidence 0.77 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 16632873 Disease Relevance 0.49 Pain Relevance 0.71
This study explored the effects of S-petasin on cellular adenosine 3':5'-cyclic monophosphate (cAMP) production, the functions of steroidogenic enzymes including cytochrome P450 side-chain cleavage enzyme (P450scc), 11beta-hydroxylase, and the expression levels of steroidogenic acute regulatory protein or P450scc.
Gene_expression (expression) of P450scc in cleavage associated with adenocard
3) Confidence 0.73 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063152 Disease Relevance 0.24 Pain Relevance 0.17
We studied the presence and activity of cytochrome P450side chain cleavage (P450scc) in rat pain pathways.
Gene_expression (presence) of cytochrome P450side chain cleavage in cleavage associated with pain
4) Confidence 0.68 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12911631 Disease Relevance 0.38 Pain Relevance 0.54
We studied the presence and activity of cytochrome P450side chain cleavage (P450scc) in rat pain pathways.
Gene_expression (presence) of P450scc in cleavage associated with pain
5) Confidence 0.68 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12911631 Disease Relevance 0.38 Pain Relevance 0.54
This study combined cellular, molecular and biochemical approaches to investigate the gene expression and enzymatic activity of cytochrome P450side-chain-cleavage (P450scc) in spinal neural networks under normal and neuropathic pain states.
Spec (investigate) Gene_expression (expression) of P450scc in spinal associated with neuropathic pain
6) Confidence 0.67 Published 2004 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 15338057 Disease Relevance 0.37 Pain Relevance 0.44
In summary, the actions of S-petasin mediate the inhibition of cAMP formation, decrease the activities of key enzymes P450scc and 11beta-hydroxylase, and reduce mRNA of steroidogenic acute regulatory protein and expression of steroidogenic acute regulatory protein.
Gene_expression (expression) of P450scc
7) Confidence 0.63 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063152 Disease Relevance 0 Pain Relevance 0.03
Effects of S-petasin on cyclic AMP production and enzyme activity of P450scc in rat zona fasciculata-reticularis cells.
Gene_expression (production) of P450scc
8) Confidence 0.63 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15063152 Disease Relevance 0.27 Pain Relevance 0.16
This study explored the effects of S-petasin on cellular adenosine 3':5'-cyclic monophosphate (cAMP) production, the functions of steroidogenic enzymes including cytochrome P450 side-chain cleavage enzyme (P450scc), 11beta-hydroxylase, and the expression levels of steroidogenic acute regulatory protein or P450scc.
Gene_expression (expression) of P450scc in cleavage associated with adenocard
9) Confidence 0.63 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063152 Disease Relevance 0.24 Pain Relevance 0.17
This study explored the effects of S-petasin on cellular adenosine 3':5'-cyclic monophosphate (cAMP) production, the functions of steroidogenic enzymes including cytochrome P450 side-chain cleavage enzyme (P450scc), 11beta-hydroxylase, and the expression levels of steroidogenic acute regulatory protein or P450scc.
Gene_expression (expression) of P450 side-chain cleavage in cleavage associated with adenocard
10) Confidence 0.55 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063152 Disease Relevance 0.25 Pain Relevance 0.17
P450scc is predominantly expressed in adrenals and gonads which produce steroid hormones for systemic use, and is expressed at a lower level in the placenta.
Gene_expression (expressed) of P450scc in placenta
11) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0 Pain Relevance 0
Very low expression of P450scc has also been detected in brain [7], kidney [8], gut [9], and skin [10]–[12], indicating production of pregnenolone at these sites for local use.
Gene_expression (expression) of P450scc in brain
12) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0 Pain Relevance 0
Previously we have reported the expression of P450scc and its electron transfer partners in the skin and demonstrated the capability of skin mitochondria and intact melanoma cells to transform cholesterol to pregnenolone [10].
Gene_expression (expression) of P450scc in skin associated with skin cancer
13) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0.21 Pain Relevance 0
P450scc is predominantly expressed in adrenals and gonads which produce steroid hormones for systemic use, and is expressed at a lower level in the placenta.
Gene_expression (expressed) of P450scc in placenta
14) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0 Pain Relevance 0
Following our previous demonstration that mammalian P450scc in an in vitro reconstituted system can cleave the side chain of 7DHC to produce 7DHP [10], we now demonstrate that adrenal glands from different mammalian species maintained ex vivo can efficiently transform 7DHC to 7DHP in a process that is dependent on P450scc activity and that includes generation of 22(OH)7DHC and 20,22(OH)27DHC as intermediates.
Gene_expression (produce) of P450scc in adrenal glands
15) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0 Pain Relevance 0
This suggests that P450scc action on 7DHC can start a novel metabolic pathway for production of steroids with an unsaturated B ring [10]. 7-DHC contains an unsaturated B ring (two double bonds in position 5 and 7) that is reduced by delta-7 reductase to produce cholesterol [14], [15].
Gene_expression (action) of P450scc
16) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0.19 Pain Relevance 0
P450scc (product of the CYP11A1 locus) is a mitochondrial enzyme that catalyzes two successive hydroxylations of the cholesterol side chain at positions 22 and 20, followed by its cleavage to produce pregnenolone and isocaproic aldehyde [3], [4].
Gene_expression (product) of P450scc in cleavage
17) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0 Pain Relevance 0
Thus, it has become crucial to test whether organs expressing P450scc can generate 5,7-diene steroids and to define whether they are biologically active.
Gene_expression (expressing) of P450scc
18) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0.20 Pain Relevance 0
Previously we have reported the expression of P450scc and its electron transfer partners in the skin and demonstrated the capability of skin mitochondria and intact melanoma cells to transform cholesterol to pregnenolone [10].
Gene_expression (transfer) of P450scc in skin associated with skin cancer
19) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629546 Disease Relevance 0.16 Pain Relevance 0
CYP1A2, CYP2A6, CYP21, CYP17, and CYP11A1), that are expressed in organs affected by the disease process.
Gene_expression (expressed) of CYP11A1 associated with disease
20) Confidence 0.32 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.24 Pain Relevance 0.04

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