INT112364

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 16.95
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
extracellular matrix 2
blood 1
PC-3 1
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 4 99.62 Very High Very High Very High
acular 3 99.62 Very High Very High Very High
palliative 2 98.44 Very High Very High Very High
Taxol 1 98.16 Very High Very High Very High
cytokine 51 97.22 Very High Very High Very High
Inflammatory response 10 91.88 High High
Central nervous system 3 89.52 High High
Arthritis 46 89.08 High High
cINOD 32 88.80 High High
agonist 64 85.44 High High
Disease Link Frequency Relevance Heat
Hypoxia 250 100.00 Very High Very High Very High
Reprotox - General 1 26 99.80 Very High Very High Very High
Cancer 761 99.32 Very High Very High Very High
Apoptosis 96 98.24 Very High Very High Very High
Esophageal Cancer 6 95.56 Very High Very High Very High
Stomach Cancer 9 93.88 High High
Acute-phase Reaction 13 93.28 High High
Atherosclerosis 10 93.28 High High
INFLAMMATION 161 91.52 High High
Diabetes Mellitus 28 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COX-2-specific inhibitor NS-398 did not inhibit HIF-1alpha or VEGF and GLUT-1.
Negative_regulation (inhibit) of HIF-1alpha
1) Confidence 0.57 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12912967 Disease Relevance 0 Pain Relevance 0
Treatment with Ibu under normoxic and hypoxic conditions reduced the level of HIF-1alpha and HIF-2alpha.
Negative_regulation (reduced) of HIF-1alpha
2) Confidence 0.57 Published 2003 Journal Clin. Cancer Res. Section Body Doc Link 12912967 Disease Relevance 0 Pain Relevance 0
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
Negative_regulation (reduction) of HIF-1alpha associated with hypoxia, cox2 and reprotox - general 1
3) Confidence 0.57 Published 2003 Journal Clin. Cancer Res. Section Title Doc Link 12912967 Disease Relevance 0.72 Pain Relevance 0.55
Long-term administration of rebamipide reduced the level of HIF-1alpha.
Negative_regulation (reduced) of HIF-1alpha
4) Confidence 0.57 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925145 Disease Relevance 0.17 Pain Relevance 0
Nuclear HIF-1alpha levels were upregulated at 0.2% oxygen but reduced by treatment with NO-sulindac, as was Akt phosphorylation.
Neg (NO) Negative_regulation (reduced) of HIF-1alpha
5) Confidence 0.57 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 18924134 Disease Relevance 1.17 Pain Relevance 0.30
In addition, the targeted inhibition of HIF-1alpha has been shown to inhibit the growth of gastric tumours in animals.
Negative_regulation (inhibition) of HIF-1alpha associated with cancer
6) Confidence 0.57 Published 2005 Journal Eur. J. Cancer Section Abstract Doc Link 16290133 Disease Relevance 1.28 Pain Relevance 0.09
Collectively, these novel findings demonstrate that NO-sulindac directly inhibits the hypoxia response of PC-3 prostate cancer cells by inhibiting HIF-1alpha translation via the Akt signalling pathway.
Negative_regulation (inhibiting) of HIF-1alpha in PC-3 associated with hypoxia and reprotox - general 1
7) Confidence 0.41 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 18924134 Disease Relevance 0.96 Pain Relevance 0
Pretreatment evaluation of combined HIF-1alpha, p53 and p21 expression is a useful and sensitive indicator of response to radiation and chemotherapy in esophageal cancer.
Negative_regulation (evaluation) of HIF-1 associated with esophageal cancer
8) Confidence 0.41 Published 2004 Journal Int. J. Cancer Section Title Doc Link 15170665 Disease Relevance 0.81 Pain Relevance 0
Combined immunohistochemical evaluation of HIF-1alpha, p53 and p21 protein expression at the pretreatment biopsy is a very useful and powerful indicator of sensitivity to CRT in human esophageal cancer.
Negative_regulation (evaluation) of HIF-1 associated with esophageal cancer
9) Confidence 0.41 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170665 Disease Relevance 0.69 Pain Relevance 0.10
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Negative_regulation (inhibitors) of HIF1A in extracellular matrix associated with cytokine
10) Confidence 0.32 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.93 Pain Relevance 0.15
As the VHL protein is a subunit in the multimeric E3 ubiquitin ligase complex, its binding to the ODD regions of HIF-1?
Negative_regulation (regions) of HIF-1
11) Confidence 0.22 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.61 Pain Relevance 0.04
Inhibition of Stat3 activation blocks HIF-1 and VEGF expression in vitro and inhibits tumor growth and angiogenesis in vivo [151].
Negative_regulation (Inhibition) of HIF-1 associated with cancer
12) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.78 Pain Relevance 0.07
pVHL-deficient A498 RCC cells, an effect that was due to inactivation of HIF-1.
Negative_regulation (inactivation) of HIF-1 associated with cancer
13) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.75 Pain Relevance 0
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Negative_regulation (inhibitors) of HIF1A in extracellular matrix associated with cytokine
14) Confidence 0.11 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.93 Pain Relevance 0.15
All patients were screened for defects in the Von Hippel-Lindau, HIF-1alpha, HIF-2alpha, PHD1-3, JAK2, and EPOR genes.
Negative_regulation (defects) of HIF-2alpha
15) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.60 Pain Relevance 0.13
All patients were screened for defects in the Von Hippel-Lindau, HIF-1alpha, HIF-2alpha, PHD1-3, JAK2, and EPOR genes.
Negative_regulation (defects) of HIF-1alpha
16) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.60 Pain Relevance 0.13
The decrease in EPC recruitment in the elderly may be associated with downregulation of tissue hypoxia-inducible factor 1 or insufficient local expression of VEGF, one of the key attractors of EPCs [14].
Negative_regulation (downregulation) of tissue hypoxia-inducible factor 1 associated with hypoxia
17) Confidence 0.09 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.57 Pain Relevance 0
Several trials of agents that decrease and/or block HIF-1?
Negative_regulation (block) of HIF-1
18) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.92 Pain Relevance 0
The asparagine hydroxylase, factor inhibitor of HIF-1, and CITED4 (CBP p300-interacting transactivator 4), which interfere with co-activator binding, provide a further level of control [28,29].
Negative_regulation (inhibitor) of HIF-1
19) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.66 Pain Relevance 0
Potential mechanisms contributing to NO chemosensitizing activity include vascular changes that promote increased blood delivery and tumor oxygenation, antioxidant effects, and glutathione detoxification/redox buffering-system down-regulation, inhibition of key transcription factors such as HIF-1 and NF-kappaB, as well as drug efflux-transporter and DNA repair-enzyme inhibition [123].
Negative_regulation (inhibition) of HIF-1 in blood associated with cancer
20) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.54 Pain Relevance 0

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