INT112365

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 27
Total Number 30
Disease Relevance 21.24
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
extracellular matrix 2
lymph node 1
endothelial cells 1
fibroblasts 1
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 123 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Snapping jaw 2 98.88 Very High Very High Very High
rheumatoid arthritis 544 97.20 Very High Very High Very High
Analgesic 1 96.72 Very High Very High Very High
opioid receptor 4 95.60 Very High Very High Very High
adenocard 26 93.76 High High
anesthesia 18 90.48 High High
cINOD 9 88.88 High High
Inflammation 234 84.76 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 636 100.00 Very High Very High Very High
Stress 234 99.76 Very High Very High Very High
Synovitis 136 99.32 Very High Very High Very High
Metastasis 54 99.18 Very High Very High Very High
Glioblastoma 1 99.16 Very High Very High Very High
Injury 70 98.96 Very High Very High Very High
Temporomandibular Joint Syndrome 2 98.88 Very High Very High Very High
Cancer 375 98.08 Very High Very High Very High
Glioma 5 97.32 Very High Very High Very High
Rheumatoid Arthritis 544 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Helicobacter pylori infection did not affected the levels of HIF-1alpha.
Neg (not) Regulation (affected) of HIF-1alpha
1) Confidence 0.60 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925145 Disease Relevance 0.17 Pain Relevance 0
Herein, we examined the expression of VEGF in synovial fibroblasts from temporomandibular joint (TMJ) under hypoxia and investigated the regulation of hypoxia-inducible factor-1alpha (HIF-1alpha) involved in the expression of VEGF.
Spec (investigated) Regulation (regulation) of HIF-1alpha in fibroblasts associated with snapping jaw and hypoxia
2) Confidence 0.60 Published 2007 Journal J. Oral Pathol. Med. Section Abstract Doc Link 17448139 Disease Relevance 0.45 Pain Relevance 0.17
Expression of hypoxia-inducible factor 1 alpha regulated genes was not influenced by cardioplegia and reperfusion, ischemic preconditioning or unstable angina.
Regulation (regulated) of hypoxia-inducible factor 1 alpha
3) Confidence 0.55 Published 2008 Journal Eur J Cardiothorac Surg Section Body Doc Link 18842422 Disease Relevance 0.06 Pain Relevance 0
stabilization and activation, some evidence indicates that cellular constituents participate in the regulation of HIF-1?
Regulation (regulation) of HIF-1
4) Confidence 0.32 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.59 Pain Relevance 0.04
Therefore, we investigated the effect of opioids on HIF-1 activity.
Spec (investigated) Regulation (effect) of HIF-1 associated with opioid
5) Confidence 0.27 Published 2005 Journal J Anesth Section Abstract Doc Link 16032459 Disease Relevance 0.42 Pain Relevance 0.55
PURPOSE: Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are considered to be potential targets for antineoplastic therapy because they regulate the expression of genes that contribute to tumor cell survival, aggressiveness, and angiogenesis.
Regulation (targets) of HIF-1alpha associated with cancer, hypoxia and aggression
6) Confidence 0.26 Published 2003 Journal Clin. Cancer Res. Section Abstract Doc Link 12912967 Disease Relevance 0.65 Pain Relevance 0.36
Our findings of up-regulation of HIF-1alpha and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis.
Regulation (regulation) of HIF-1alpha associated with glioma
7) Confidence 0.26 Published 2007 Journal Neurosurg Rev Section Abstract Doc Link 17486380 Disease Relevance 0.79 Pain Relevance 0
Transcript of heme oxygenase 1 (HMOX1), an essential enzyme in heme catabolism and a direct target of HIF1 (see stress response), was also upregulated.
Regulation (target) of HIF1 associated with stress
8) Confidence 0.24 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.29 Pain Relevance 0
It should be noted that dysregulation of HIF1A, a gene playing a major role in hypoxia, was observed in this study.
Regulation (dysregulation) of HIF1A associated with hypoxia
9) Confidence 0.20 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.57 Pain Relevance 0.41
Hypoxia can promote lymph node metastasis via up-regulation of PLAUR [39], and up-regulation of HIF1a, JUN and PLAUR in our invasive cell lines hints at possible activation of JUN/AP1 and HIF/ARNT pathways in melanoma (Figure 5).
Regulation (regulation) of HIF1a in lymph node associated with melanoma, hypoxia and metastasis
10) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.63 Pain Relevance 0
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Regulation (dysregulated) of HIF1A in extracellular matrix associated with cytokine
11) Confidence 0.09 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.01 Pain Relevance 0.17
Delivery of intracellular modulators for therapeutic angiogenesis, including transcription factors that control angiogenesis such as hypoxia inducible factor-1 alpha (HIF-1?)
Regulation (control) of hypoxia inducible factor-1 alpha associated with hypoxia
12) Confidence 0.08 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC64829 Disease Relevance 0.21 Pain Relevance 0
Caffeine antagonizes the up-regulation of factor-1 (HIF-1) along with VEGF, and IL-8.
Regulation (regulation) of HIF-1
13) Confidence 0.07 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.69 Pain Relevance 0.03
Here, we provide a view suggesting that caffeine could exert some of its effects by acting on several signaling complexes composed of HIF-1?
Regulation (acting) of HIF-1
14) Confidence 0.07 Published 2010 Journal Current Neuropharmacology Section Abstract Doc Link PMC2923369 Disease Relevance 0.51 Pain Relevance 0.05
Also up regulation was observed for HIF-1 and C5AR by BoNTA and CT and there was good agreement with data from the microarray studies (Fig. 10).


Regulation (regulation) of HIF-1
15) Confidence 0.06 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2542375 Disease Relevance 0 Pain Relevance 0
The biological basis of this process has been well studied, and relates to the exquisite regulation of a key transcription factor, HIF-1?
Regulation (regulation) of HIF-1
16) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.48 Pain Relevance 0.20
Although several mechanisms have been proposed for oxygen sensing, it has been shown that the primary mechanism by which hypoxia directly regulates HIF-1?
Regulation (regulates) of HIF-1 associated with hypoxia
17) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.07 Pain Relevance 0.03
PHD2 is the key oxygen sensor involved in setting a low steady-state level of HIF-1?
Regulation (setting) of HIF-1
18) Confidence 0.06 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.87 Pain Relevance 0
Although we did not identify these genes in this SSH screen, we found the key oxygen sensor, PHD2, which regulates the HIF-1 transcription complex, that subsequently regulates VEGF expression and we found a kinase, SNRK, that regulates a second kinase, LKB1, that is a component of the VEGF signalling pathway.
Regulation (regulates) of HIF-1
19) Confidence 0.06 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.46 Pain Relevance 0
The hypoxia-inducible factor (HIF-1) is a trimeric master transcription factor controlling the expression of several genes involved in a variety of processes in endothelial cells, including glucose metabolism, erythro-poiesis, regulation of vascular tone, and cell proliferation and survival (Wenger and Gassmann 1997).
Regulation (controlling) of HIF-1 in endothelial cells associated with hypoxia
20) Confidence 0.05 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.35 Pain Relevance 0

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