INT112368

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 2.94
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cacna1c) nucleus (Cacna1c) transmembrane transport (Cacna1c)
cytoplasm (Cacna1c)
Anatomy Link Frequency
cardiomyocytes 1
red blood cells 1
Cacna1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 37 99.96 Very High Very High Very High
adenocard 3 98.44 Very High Very High Very High
cINOD 6 97.12 Very High Very High Very High
addiction 51 96.36 Very High Very High Very High
anesthesia 8 94.56 High High
Neurotransmitter 32 94.16 High High
qutenza 6 89.52 High High
Kinase C 2 86.16 High High
Glutamate 65 80.68 Quite High
Pain 9 80.40 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 5 98.48 Very High Very High Very High
INFLAMMATION 5 96.68 Very High Very High Very High
Hypertrophy 24 93.60 High High
Pancreatitis 80 93.04 High High
Hypertension 14 90.00 High High
Pressure Volume 2 Under Development 2 88.36 High High
Nociception 7 87.04 High High
Coronary Heart Disease 36 84.76 Quite High
Pain 7 80.40 Quite High
Diabetic Neuropathy 3 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phospholipase A2 group IIA (PLA2-IIA) and L-type calcium channel (Cacna1c) genes were upregulated in cardiomyocytes and VSMC after stimulation with both purified antibodies from patients and from rabbit [5].
Positive_regulation (upregulated) of Cacna1c in cardiomyocytes associated with calcium channel
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.45 Pain Relevance 0.09
In this study, we also found a long-term upregulation of Cacna1c.
Positive_regulation (upregulation) of Cacna1c
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.54 Pain Relevance 0.08
T-type currents and ADPs were potently inhibited by nickel and enhanced by L-cysteine, suggesting that the Ca(V)3.2 T-type channel isoform was upregulated.
Positive_regulation (upregulated) of T-type channel isoform
3) Confidence 0.25 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17376991 Disease Relevance 1.05 Pain Relevance 0.61
The toxic effectiveness of acid nonsteroidal anti-inflammatory drugs (NSAIDs) was systemically examined by the depletion of intracorpuscular adenosine triphosphate (ATP), glutathione (GSH), and hemoglobin (Hb) at various doses, increased every 5 fmol/RBC.
Positive_regulation (increased) of RBC associated with adenocard, inflammation and cinod
4) Confidence 0.18 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12913268 Disease Relevance 0.17 Pain Relevance 0.58
According to the statistical results, the level of RBC in male groups of F and G and percentage of PCV in female and male groups of F and content of Hb, in female groups of F, were significantly increased in comparison to the control group and variation of results in other groups were not significant.
Positive_regulation (increased) of RBC
5) Confidence 0.15 Published 2007 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19093535 Disease Relevance 0 Pain Relevance 0.09
This is in keeping with the increase in GCL activity in red blood cells (RBC) after 5 days of pre-treatment with probiotics (fig 8B).
Positive_regulation (increase) of RBC in red blood cells
6) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.68 Pain Relevance 0
For example, the long duration of the depolarizing potassium stimulus may increase the apparent contribution of the L-type channel to CGRP release, due to the slow Ca2+-dependent inactivation of L-type channels compared to the faster voltage-dependent inactivation exhibited by the P/Q- and N-type channels (but see Lipscombe et al, 2004 [43]).
Spec (may) Positive_regulation (increase) of L-type channel
7) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2359740 Disease Relevance 0.06 Pain Relevance 0.42
S2 shows that CREB signal strength is steeply dependent on L-type channel activity.
Positive_regulation (dependent) of L-type channel
8) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.05
Second, upon L-type channel activation, pCaMKII puncta formed at the cell surface.
Positive_regulation (activation) of L-type channel
9) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.04
Together, these data support the hypothesis that local changes in CaMKII activation help couple L-type channel activation to the nuclear response.


Positive_regulation (activation) of L-type channel
10) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0

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