INT112372

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 5.49
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GPSM2) nucleolus (GPSM2) nucleus (GPSM2)
cytoplasm (GPSM2)
Anatomy Link Frequency
LGN 2
cortex 2
neuronal 1
eye 1
GPSM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
glial activation 4 100.00 Very High Very High Very High
Neuritis 10 99.96 Very High Very High Very High
imagery 15 99.32 Very High Very High Very High
agonist 2 93.04 High High
Central nervous system 44 89.64 High High
Inflammation 7 86.76 High High
Deafferentation 8 86.72 High High
cytokine 2 77.44 Quite High
Neurotransmitter 2 68.04 Quite High
Action potential 8 67.28 Quite High
Disease Link Frequency Relevance Heat
Optic Neuritis 10 99.96 Very High Very High Very High
Cramps 1 99.40 Very High Very High Very High
Amblyopia 35 99.24 Very High Very High Very High
Ocular Hypertension 142 98.24 Very High Very High Very High
Death 6 95.56 Very High Very High Very High
Glaucoma 18 92.64 High High
Knee Injuries 1 91.44 High High
Ganglion Cysts 16 88.88 High High
Optic Nerve Injuries 70 87.92 High High
INFLAMMATION 7 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the patient with unilateral optic neuritis, activation of the LGN and visual cortex was markedly decreased when the affected eye was stimulated.
Positive_regulation (activation) of LGN in eye associated with optic neuritis and neuritis
1) Confidence 0.41 Published 2003 Journal Ophthalmologica Section Abstract Doc Link 12913328 Disease Relevance 0.58 Pain Relevance 0.26
We used functional magnetic resonance imaging (fMRI) to study monocular visual activation of the LGN in a patient with anisometropic amblyopia.
Positive_regulation (activation) of LGN in LGN associated with amblyopia and imagery
2) Confidence 0.41 Published 2003 Journal Ophthalmologica Section Abstract Doc Link 12913328 Disease Relevance 0.51 Pain Relevance 0.24
Similarly, decreased activation of the LGN as well as the visual cortex by the affected eye was demonstrated in the patient with anisometropic amblyopia.
Positive_regulation (activation) of LGN in cortex associated with amblyopia
3) Confidence 0.41 Published 2003 Journal Ophthalmologica Section Abstract Doc Link 12913328 Disease Relevance 0.56 Pain Relevance 0.25
In the 4 normal subjects, comparable activation of the LGN and visual cortex was obtained by stimulation of either the right or left eye.
Positive_regulation (activation) of LGN in cortex
4) Confidence 0.41 Published 2003 Journal Ophthalmologica Section Abstract Doc Link 12913328 Disease Relevance 0.58 Pain Relevance 0.26
Our preliminary results suggest that activation of the LGN is diminished during monocular viewing by affected eyes in anisometropic amblyopia. fMRI appears to be a feasible method to study LGN activity in human amblyopia.
Positive_regulation (activation) of LGN in LGN associated with amblyopia
5) Confidence 0.41 Published 2003 Journal Ophthalmologica Section Abstract Doc Link 12913328 Disease Relevance 0.72 Pain Relevance 0.23
Currently, surgeons performing ACL reconstruction use screws, pins, buttons, and cramps for graft fixation because of individual preference, or institutional orders.
Positive_regulation (performing) of pins associated with cramps
6) Confidence 0.24 Published 2005 Journal BMC Surg Section Body Doc Link PMC552311 Disease Relevance 0.19 Pain Relevance 0
The objective of this study was to identify the early changes in neuronal activity and glial activation in the LGN and V1 after short-term unilateral elevated IOP (two weeks to two months) in primates with OHT.
Positive_regulation (activation) of LGN in neuronal associated with ocular hypertension and glial activation
7) Confidence 0.22 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 1.08 Pain Relevance 0.37
Differences in species as well as the method of inducing elevated IOP used in Wang et al.’s study may account for the observed differences in the microglial activation in the rodent LGN [49].
Positive_regulation (activation) of LGN associated with ocular hypertension
8) Confidence 0.22 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 1.27 Pain Relevance 0.19
40 of 109) from the cat LGN, MGN and VB maintained in vitro exhibited spontaneous firing that was modulated by a prominent infra-slow (<0.1 Hz) oscillation (ISO) (individual drug application: 0.034±0.01 Hz; n?
Positive_regulation (cat) of LGN
9) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637539 Disease Relevance 0 Pain Relevance 0.15

General Comments

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