INT1124

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Context Info
Confidence 0.57
First Reported 1978
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 53
Total Number 53
Disease Relevance 36.26
Pain Relevance 7.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
plasma 3
B cells 2
platelet 1
memory B-cells 1
osteoclast 1
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 22 99.76 Very High Very High Very High
Multiple sclerosis 44 99.56 Very High Very High Very High
Angina 58 99.28 Very High Very High Very High
rheumatoid arthritis 392 98.52 Very High Very High Very High
carpal tunnel syndrome 3 98.48 Very High Very High Very High
Arthritis 96 98.12 Very High Very High Very High
Inflammation 162 98.02 Very High Very High Very High
cytokine 182 96.96 Very High Very High Very High
Infliximab 40 95.96 Very High Very High Very High
tolerance 15 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 37 100.00 Very High Very High Very High
Urological Neuroanatomy 28 99.96 Very High Very High Very High
Bacterial Infection 4 99.68 Very High Very High Very High
Leptospirosis 7 99.66 Very High Very High Very High
Demyelinating Disease 52 99.56 Very High Very High Very High
Systemic Lupus Erythematosus 249 99.48 Very High Very High Very High
Cv General 3 Under Development 14 99.28 Very High Very High Very High
Multiple Myeloma 47 99.24 Very High Very High Very High
Acute Coronary Syndrome 78 99.16 Very High Very High Very High
Mumps 90 98.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Impact of clopidogrel on suppression of circulating levels of soluble CD40 ligand in patients with unstable angina undergoing coronary stenting.
Negative_regulation (suppression) of CD40 ligand associated with angina
1) Confidence 0.57 Published 2006 Journal Am. J. Cardiol. Section Title Doc Link 16442361 Disease Relevance 0.19 Pain Relevance 0.23
Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo.
Negative_regulation (reduced) of IgM associated with cinod
2) Confidence 0.57 Published 1984 Journal Inflammation Section Abstract Doc Link 6592146 Disease Relevance 0.17 Pain Relevance 0.63
Previous reports showed a decrease of IgM-RF during anti-TNF treatment [11-13].
Negative_regulation (decrease) of IgM
3) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656247 Disease Relevance 0.47 Pain Relevance 0.46
Denosumab patients with prior IV BP exposure had marked suppression of the osteoclast marker TRAP-5b (median reduction: denosumab 73%, IV BP 11%).
Negative_regulation (suppression) of TRAP in osteoclast
4) Confidence 0.57 Published 2010 Journal J. Bone Miner. Res. Section Abstract Doc Link 19653815 Disease Relevance 0.64 Pain Relevance 0.09
Lambda light chains were the sole contributors to a selective increase in IgD, with a concomitant reduction of IgA, IgG, and IgM.
Negative_regulation (reduction) of IgM
5) Confidence 0.44 Published 1981 Journal J. Neurol. Section Abstract Doc Link 6169807 Disease Relevance 1.00 Pain Relevance 0.15
This study investigated whether a regimen that comprised a loading dose of 300 mg of clopidogrel followed by 75 mg/day could significantly suppress circulating levels of soluble CD40 ligand (sCD40L) in patients who had unstable angina and underwent coronary stenting.
Negative_regulation (suppress) of CD40 ligand associated with angina
6) Confidence 0.42 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 16442361 Disease Relevance 0.17 Pain Relevance 0.21
Mild leptospirosis with three-year persistence of IgG- and IgM-antibodies, initially manifesting as carpal tunnel syndrome.
Negative_regulation (persistence) of IgM associated with leptospirosis and carpal tunnel syndrome
7) Confidence 0.42 Published 2005 Journal J. Infect. Section Title Doc Link 16038755 Disease Relevance 0.95 Pain Relevance 0.26
Low SF patients (n=8) showed post-ex decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L, and TNFalpha (p<.05).
Negative_regulation (decreased) of CD40L
8) Confidence 0.39 Published 2010 Journal Psychophysiology Section Abstract Doc Link 20230500 Disease Relevance 0.55 Pain Relevance 0.30
Moreover, blockade of CD154 with an antibody ameliorates collagen induced arthritis in a murine model of RA [31].
Negative_regulation (blockade) of CD154 associated with rheumatoid arthritis, experimental arthritis and arthritis
9) Confidence 0.37 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.79 Pain Relevance 0.75
In both skin biopsy samples from urticarial and purpuric eruptions, mild inflammatory infiltration by polymorphonuclear leukocytes with nuclear dust, extravasation of erythrocytes and deposition of IgM and C3 in the superficial blood vessels were observed.
Negative_regulation (deposition) of IgM in polymorphonuclear leukocytes associated with inflammation
10) Confidence 0.32 Published 2003 Journal J. Dermatol. Section Abstract Doc Link 12707469 Disease Relevance 1.13 Pain Relevance 0.13
In contrast, though less well studied, it appears that IgM is lost in 50% of patients after 45 days and is absent in 100% by 4 months after infection (25).
Negative_regulation (lost) of IgM associated with infection
11) Confidence 0.31 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2600406 Disease Relevance 1.54 Pain Relevance 0.12
The CFA effectively removed 93% of CG, without significant removal of IgG, IgM, IgA, albumin, and fibrinogen.
Negative_regulation (removal) of IgM
12) Confidence 0.30 Published 1999 Journal ASAIO J. Section Abstract Doc Link 10360729 Disease Relevance 1.28 Pain Relevance 0.07
Low SF patients (n=8) showed post-ex decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L, and TNFalpha (p<.05).
Negative_regulation (decreases) of CD40L
13) Confidence 0.29 Published 2010 Journal Psychophysiology Section Abstract Doc Link 20230500 Disease Relevance 0.57 Pain Relevance 0.30
Blockade of the CD40L pathway was successful but not safe with BG9588 (because of thrombotic complications) and safe but not effective for IDEC [14,15].
Negative_regulation (Blockade) of CD40L
14) Confidence 0.27 Published 2010 Journal BMC Med Section Body Doc Link PMC3009611 Disease Relevance 0.89 Pain Relevance 0.22
Soluble CD40L decreased with UFP exposure.
Negative_regulation (decreased) of CD40L
15) Confidence 0.24 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC3002188 Disease Relevance 0.39 Pain Relevance 0.05
An increase in platelet expression of CD40L was detected 3.5 hr after UFP exposure, yet soluble CD40L levels decreased, reaching a nadir 21 hr after exposure.
Negative_regulation (decreased) of CD40L in platelet
16) Confidence 0.24 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.49 Pain Relevance 0
Soluble CD40L decreased significantly after UFP exposure (Figure 2C) (UFP effect, p = 0.021), a direction that was opposite of what we expected.
Negative_regulation (decreased) of CD40L
17) Confidence 0.24 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.31 Pain Relevance 0
Immunoglobulin levels, particularly IgM and IgE, were reduced in some belimumab cohorts compared with placebo.
Negative_regulation (reduced) of IgM
18) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.35 Pain Relevance 0.04
Gradual reductions in CD20 B cells and immunoglobulin isotypes, particularly IgM, were observed [41,42].
Negative_regulation (reductions) of IgM in B cells
19) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.62 Pain Relevance 0.18
On the other hand, soluble plasma CD40L decreased after exposure.
Negative_regulation (decreased) of CD40L in plasma
20) Confidence 0.21 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.31 Pain Relevance 0

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