INT112418

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (FKBP5) protein folding (FKBP5) nucleolus (FKBP5)
nucleus (FKBP5) cytoplasm (FKBP5)
FKBP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 14 98.94 Very High Very High Very High
COX2 4 98.62 Very High Very High Very High
Neuropeptide 1 86.40 High High
Dopamine 1 81.84 Quite High
Serotonin 4 81.44 Quite High
Locus ceruleus 1 75.32 Quite High
medulla 2 74.68 Quite High
depression 3 42.96 Quite Low
nMDA receptor 1 8.08 Low Low
agonist 3 6.96 Low Low
Disease Link Frequency Relevance Heat
Post-traumatic Stress Disorder 166 98.64 Very High Very High Very High
Reprotox - General 1 6 95.56 Very High Very High Very High
Shock 1 90.24 High High
Cancer 2 90.20 High High
INFLAMMATION 4 88.36 High High
Disorder Of Lipid Metabolism 1 84.32 Quite High
Anxiety Disorder 65 78.60 Quite High
Injury 35 71.04 Quite High
Depression 3 42.96 Quite Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, as part of the largest genetic study of PTSD to date, Binder and colleagues146 studied the relationship between FKBP5 polymorphisms and past child abuse on one’s susceptibility to developing PTSD.
Gene_expression (polymorphisms) of FKBP5 associated with post-traumatic stress disorder
1) Confidence 0.43 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938301 Disease Relevance 1.12 Pain Relevance 0.20
We found that two cyclooxygenase 2-specific NSAIDs, celecoxib and nimesulide, dramatically reduced the expression of androgen-inducible genes, such as prostate-specific antigen, hK2, and the FK506-binding protein 51 (FKBP51).
Gene_expression (expression) of FK506-binding protein 51 associated with cinod and cox2
2) Confidence 0.29 Published 2003 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 12917209 Disease Relevance 0.42 Pain Relevance 0.71
We found that two cyclooxygenase 2-specific NSAIDs, celecoxib and nimesulide, dramatically reduced the expression of androgen-inducible genes, such as prostate-specific antigen, hK2, and the FK506-binding protein 51 (FKBP51).
Gene_expression (expression) of FKBP51 associated with cinod and cox2
3) Confidence 0.29 Published 2003 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 12917209 Disease Relevance 0.42 Pain Relevance 0.71

General Comments

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