INT112420

Context Info Confidence 0.16 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.85 Pain Relevance 1.42

isomerase activity (FKBP5) protein folding (FKBP5) nucleolus (FKBP5) nucleus (FKBP5) cytoplasm (FKBP5)

FKBP5 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 14 99.18 COX2 4 98.86

Disease Link Frequency Relevance Heat Reprotox - General 1 6 96.04 Cancer 2 90.68 INFLAMMATION 4 88.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that two cyclooxygenase 2-specific NSAIDs, celecoxib and nimesulide, dramatically reduced the expression of androgen-inducible genes, such as prostate-specific antigen, hK2, and the FK506-binding protein 51 (FKBP51).

Negative_regulation (reduced) of Gene_expression (expression) of FK506-binding protein 51 associated with cinod and cox2

1) Confidence 0.16 Published 2003 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 12917209 Disease Relevance 0.43 Pain Relevance 0.71

We found that two cyclooxygenase 2-specific NSAIDs, celecoxib and nimesulide, dramatically reduced the expression of androgen-inducible genes, such as prostate-specific antigen, hK2, and the FK506-binding protein 51 (FKBP51).

Negative_regulation (reduced) of Gene_expression (expression) of FKBP51 associated with cinod and cox2

2) Confidence 0.16 Published 2003 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 12917209 Disease Relevance 0.43 Pain Relevance 0.71

General Comments

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