INT112427

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 26.29
Pain Relevance 21.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
microglia 9
nerve 6
spinal cord 3
dorsal horn 2
neurons 1
P2rx4 (Rattus norvegicus)
P2rx4 - Q78K (1)
Pain Link Frequency Relevance Heat
Brush evoked pain 194 99.98 Very High Very High Very High
Spinal cord 171 99.88 Very High Very High Very High
Neuropathic pain 316 99.80 Very High Very High Very High
Lasting pain 40 99.62 Very High Very High Very High
Stimulus evoked pain 32 99.28 Very High Very High Very High
intrathecal 45 98.54 Very High Very High Very High
Dorsal horn 118 98.20 Very High Very High Very High
allodynia 114 98.20 Very High Very High Very High
Pain 243 97.92 Very High Very High Very High
cytokine 63 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 657 99.98 Very High Very High Very High
Pain 318 99.62 Very High Very High Very High
Hypersensitivity 56 99.08 Very High Very High Very High
Nervous System Injury 311 98.48 Very High Very High Very High
Injury 128 95.92 Very High Very High Very High
Shock 6 88.56 High High
INFLAMMATION 115 87.84 High High
Frailty 6 87.72 High High
Inflammatory Pain 44 86.60 High High
Hypertrophy 10 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here that tactile allodynia under chronic pain states requires an activation of the P2X4 ionotropic ATP receptor and p38 mitogen-activated protein kinase (MAPK) in spinal cord microglia.
Positive_regulation (activation) of P2X4 in microglia associated with brush evoked pain, lasting pain and spinal cord
1) Confidence 0.68 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.03 Pain Relevance 0.86
Intraspinal administration of P2X4 antisense oligodeoxynucleotide (ODN) reduced induction of P2X4 and suppressed tactile allodynia.
Positive_regulation (induction) of P2X4 associated with brush evoked pain
2) Confidence 0.68 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 0.97 Pain Relevance 0.98
We also found that the expression level of P2X4 was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade of P2X4 reversed the allodynia.
Positive_regulation (increased) of P2X4 in spinal cord associated with nervous system injury, allodynia and spinal cord
3) Confidence 0.68 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.15 Pain Relevance 1.07
Taken together our results demonstrate that activation of P2X4 or p38 MAPK in spinal cord microglia is necessary for tactile allodynia following nerve injury.
Positive_regulation (activation) of P2X4 in nerve associated with brush evoked pain, nervous system injury and spinal cord
4) Confidence 0.68 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.07 Pain Relevance 0.91
After nerve injury, P2X4R expression increased strikingly in the ipsilateral spinal cord, and P2X4Rs were induced in hyperactive microglia but not in neurons or astrocytes.
Neg (not) Positive_regulation (induced) of P2X4Rs in neurons associated with nervous system injury and spinal cord
5) Confidence 0.66 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.43 Pain Relevance 0.96
Intraspinal administration of P2X4R antisense oligodeoxynucleotide decreased the induction of P2X4Rs and suppressed tactile allodynia after nerve injury.
Positive_regulation (induction) of P2X4Rs in nerve associated with brush evoked pain and nervous system injury
6) Confidence 0.66 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.45 Pain Relevance 1.03
Taken together, our results demonstrate that activation of P2X4Rs in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactile allodynia in normal animals.
Positive_regulation (activation) of P2X4Rs in nerve associated with brush evoked pain and nervous system injury
7) Confidence 0.66 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.41 Pain Relevance 1.03
P2X4R or P2X7R activation leads to the release of bioactive diffusible factors such as BDNF and other proinflammatory factors (cytokines and chemokines).
Positive_regulation (activation) of P2X4R associated with chemokine and cytokine
8) Confidence 0.57 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.69 Pain Relevance 0.73
Increase of P2X4R+, beta-APP+ hypertrophic neurites correlated with proximity to the lesion.
Positive_regulation (Increase) of P2X4R in neurites
9) Confidence 0.45 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15885321 Disease Relevance 0.80 Pain Relevance 0.27
After formalin administration, an increase of P2X4R+ microglia were observed in the spinal cord dorsal horn on the side ipsilateral to the injection, reaching maximal levels by day 7, and then decreasing to normal levels by day 14.
Positive_regulation (increase) of P2X4R in spinal cord dorsal horn associated with dorsal horn and spinal cord
10) Confidence 0.43 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15885314 Disease Relevance 0.43 Pain Relevance 0.53
Conversely, intraspinal administration of microglia in which P2X4Rs had been induced and stimulated, produced tactile allodynia in naive rats.
Positive_regulation (induced) of P2X4Rs in microglia associated with brush evoked pain
11) Confidence 0.39 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.44 Pain Relevance 1.04
In naïve rats, intrathecal administration of cultured microglia that were preincubated with ATP to activate P2X4 produced tactile allodynia over the 3–5 h after the administration [10].
Positive_regulation (activate) of P2X4 in microglia associated with brush evoked pain and intrathecal
12) Confidence 0.38 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.98 Pain Relevance 0.89
In otherwise naive animals, intrathecal administration of cultured microglia that were preincubated with ATP to activate P2X4 on microglia produced tactile allodynia progressively over the 3– h following the administration.
Positive_regulation (activate) of P2X4 in microglia associated with brush evoked pain and intrathecal
13) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.09 Pain Relevance 0.81
From the pharmacological profiles of TNP-ATP (blocking P2X4 at high concentration) and PPADS (not blocking P2X4), it was inferred that tactile allodynia depends upon P2X4 in the spinal cord.
Positive_regulation (depends) of P2X4 in spinal cord associated with brush evoked pain and spinal cord
14) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.19 Pain Relevance 0.98
The activated microglia express P2X4, which can be stimulated by endogenous ATP, resulting in BDNF release and expression of neuropathic pain.
Positive_regulation (stimulated) of P2X4 in microglia associated with neuropathic pain
15) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.03 Pain Relevance 0.97
Collectively, this evidence implies that activation of microglial P2X4 is necessary for pain hypersensitivity following nerve injury.
Positive_regulation (activation) of P2X4 in nerve associated with nervous system injury, hypersensitivity and stimulus evoked pain
16) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.06 Pain Relevance 0.76
Intraspinal administration of P2X4 receptor antisense oligodeoxynucleotide decreased induction of P2X4 receptors and suppressed tactile allodynia after nerve injury.
Positive_regulation (induction) of P2X4 in nerve associated with brush evoked pain and nervous system injury
17) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.58 Pain Relevance 0.28
Intraspinal administration of P2X4 antisense oligodeoxynucleotide decreased induction of P2X4 and suppressed tactile allodynia after nerve injury.
Positive_regulation (induction) of P2X4 in nerve associated with brush evoked pain and nervous system injury
18) Confidence 0.23 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 1.02 Pain Relevance 0.64
In activated microglia, P2X4 is up-regulated and promotes BDNF release in spinal cord neurons contributing to pain signalling [33].
Positive_regulation (promotes) of P2X4 in spinal cord neurons associated with pain and spinal cord
19) Confidence 0.22 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.10 Pain Relevance 0.15
Conversely, intraspinal administration of microglia in which P2X4 had been induced and stimulated produced tactile allodynia in naive rats.
Positive_regulation (induced) of P2X4 in microglia associated with brush evoked pain
20) Confidence 0.20 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 1.03 Pain Relevance 0.68

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