INT112428

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 12.67
Pain Relevance 9.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
microglia 8
spinal cord 6
nerve 4
spinal 2
neurons 2
P2rx4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 103 100.00 Very High Very High Very High
Brush evoked pain 80 99.96 Very High Very High Very High
Neuropathic pain 223 99.76 Very High Very High Very High
allodynia 60 99.00 Very High Very High Very High
Peripheral nerve injury 48 98.92 Very High Very High Very High
intrathecal 24 98.54 Very High Very High Very High
Acute pain 6 98.00 Very High Very High Very High
Lasting pain 23 97.96 Very High Very High Very High
Dorsal horn 71 96.56 Very High Very High Very High
Stimulus evoked pain 22 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Frailty 7 99.98 Very High Very High Very High
Neuropathic Pain 389 99.96 Very High Very High Very High
Nervous System Injury 208 99.96 Very High Very High Very High
Pain 158 98.00 Very High Very High Very High
Hypersensitivity 36 97.08 Very High Very High Very High
Targeted Disruption 12 90.04 High High
Injury 146 87.28 High High
Hyperalgesia 28 86.04 High High
Infection 15 80.56 Quite High
Diabetes Mellitus 11 80.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that the expression level of P2X4 was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade of P2X4 reversed the allodynia.
Positive_regulation (increased) of Gene_expression (expression) of P2X4 in spinal cord associated with nervous system injury, allodynia and spinal cord
1) Confidence 0.68 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.15 Pain Relevance 1.07
Spinal cord injury induces early and persistent lesional P2X4 receptor expression.
Positive_regulation (induces) of Gene_expression (expression) of P2X4 receptor in Spinal cord associated with spinal cord
2) Confidence 0.63 Published 2005 Journal J. Neuroimmunol. Section Title Doc Link 15885321 Disease Relevance 0.93 Pain Relevance 0.34
After nerve injury, P2X4R expression increased strikingly in the ipsilateral spinal cord, and P2X4Rs were induced in hyperactive microglia but not in neurons or astrocytes.
Positive_regulation (increased) of Gene_expression (expression) of P2X4R in neurons associated with nervous system injury and spinal cord
3) Confidence 0.58 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.43 Pain Relevance 0.96
The expression of P2X4 protein, normally low in the naïve spinal cord, progressively increased in the days following nerve injury with a time course parallel to that of the development of tactile allodynia.
Positive_regulation (increased) of Gene_expression (expression) of P2X4 in nerve associated with brush evoked pain, nervous system injury and spinal cord
4) Confidence 0.57 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.10 Pain Relevance 0.97
The expression of P2X4 receptors in the spinal cord is enhanced in spinal microglia after peripheral nerve injury, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain behaviour.
Positive_regulation (enhanced) of Gene_expression (expression) of P2X4 in spinal associated with nervous system injury, neuropathic pain, peripheral nerve injury and spinal cord
5) Confidence 0.45 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096535 Disease Relevance 1.18 Pain Relevance 1.06
In naïve rats, intrathecal administration of cultured microglia that were preincubated with ATP to activate P2X4 produced tactile allodynia over the 3–5 h after the administration [10].
Positive_regulation (activate) of Gene_expression (produced) of P2X4 in microglia associated with brush evoked pain and intrathecal
6) Confidence 0.41 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.99 Pain Relevance 0.90
After nerve injury, expression of P2X4 increased strikingly in hyperactive microglia (but not in neurons or astrocytes) of the ipsilateral spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of P2X4 in microglia associated with nervous system injury and spinal cord
7) Confidence 0.34 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.98 Pain Relevance 0.62
The expression of P2X4 protein, normally low in the naive spinal cord, progressively increased in the days following nerve injury with a time-course parallel to that of the development of tactile allodynia.
Positive_regulation (increased) of Gene_expression (expression) of P2X4 protein in spinal cord associated with brush evoked pain, nervous system injury and spinal cord
8) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.16 Pain Relevance 0.99
The activated microglia express P2X4, which can be stimulated by endogenous ATP, resulting in BDNF release and expression of neuropathic pain.
Positive_regulation (stimulated) of Gene_expression (express) of P2X4 in microglia associated with neuropathic pain
9) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.03 Pain Relevance 0.97
After spinal-nerve injury, P2X4 receptor expression strikingly increased at the ipsilateral site in hyperactive microglia but not in neurons or astrocytes [40].
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of P2X4 in astrocytes associated with nervous system injury
10) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.57 Pain Relevance 0.22
Following a similar approach, Tsuda et al [158] demonstrated an increase in P2X4 receptor expression after chronic nerve injury, and showed that both pharmacological blockade and anti-sense oligonucleotide treatment abrogates the development of mechanical allodynia.
Positive_regulation (increase) of Gene_expression (expression) of P2X4 in nerve associated with nervous system injury and allodynia
11) Confidence 0.27 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.84 Pain Relevance 0.49
For example, fibronectin is known to cross the opened BBB [26] and this is known to stimulate P2X4R expression in microglia [27], and this increase in P2X4 is critical for mechanical hypersensitivity after PNI [28,29].
Positive_regulation (stimulate) of Gene_expression (expression) of P2X4R in microglia associated with hypersensitivity and peripheral nerve injury
12) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 1.32 Pain Relevance 0.98

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