INT112429

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.03
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
nerve 6
P2rx4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Brush evoked pain 17 99.36 Very High Very High Very High
Spinal cord 7 97.28 Very High Very High Very High
allodynia 3 97.04 Very High Very High Very High
Acute pain 2 90.08 High High
Peripheral nerve injury 2 88.92 High High
Pain 7 78.28 Quite High
Dorsal horn 1 76.20 Quite High
Stimulus evoked pain 1 75.84 Quite High
Lasting pain 2 75.00 Quite High
Inflammation 27 74.56 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 99.36 Very High Very High Very High
Nervous System Injury 17 98.40 Very High Very High Very High
Pain 11 90.08 High High
Hypersensitivity 1 75.84 Quite High
Injury 52 75.24 Quite High
INFLAMMATION 30 74.56 Quite High
Neurological Disease 1 73.52 Quite High
Cv Unclassified Under Development 3 60.64 Quite High
Death 5 47.56 Quite Low
Demyelinating Disease 6 22.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraspinal administration of P2X4 antisense oligodeoxynucleotide (ODN) reduced induction of P2X4 and suppressed tactile allodynia.
Negative_regulation (reduced) of Positive_regulation (induction) of P2X4 associated with brush evoked pain
1) Confidence 0.57 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 0.97 Pain Relevance 0.98
Intraspinal administration of P2X4R antisense oligodeoxynucleotide decreased the induction of P2X4Rs and suppressed tactile allodynia after nerve injury.
Negative_regulation (decreased) of Positive_regulation (induction) of P2X4Rs in nerve associated with brush evoked pain and nervous system injury
2) Confidence 0.56 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.45 Pain Relevance 1.03
Intraspinal administration of P2X4 antisense oligodeoxynucleotide decreased induction of P2X4 and suppressed tactile allodynia after nerve injury.
Negative_regulation (decreased) of Positive_regulation (induction) of P2X4 in nerve associated with brush evoked pain and nervous system injury
3) Confidence 0.21 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 1.02 Pain Relevance 0.64
Intraspinal administration of P2X4 receptor antisense oligodeoxynucleotide decreased induction of P2X4 receptors and suppressed tactile allodynia after nerve injury.
Negative_regulation (decreased) of Positive_regulation (induction) of P2X4 in nerve associated with brush evoked pain and nervous system injury
4) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.58 Pain Relevance 0.28

General Comments

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