INT112430

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.40
Pain Relevance 6.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
spinal cord 3
nerve 1
peripheral nerve 1
hippocampus 1
microglia 1
P2rx4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 28 100.00 Very High Very High Very High
allodynia 43 99.44 Very High Very High Very High
Brush evoked pain 53 99.04 Very High Very High Very High
Spinal cord 45 98.90 Very High Very High Very High
agonist 71 98.08 Very High Very High Very High
Pain 64 97.84 Very High Very High Very High
adenocard 25 97.48 Very High Very High Very High
Peripheral nerve injury 14 96.88 Very High Very High Very High
Acute pain 4 95.88 Very High Very High Very High
intrathecal 18 94.88 High High
Disease Link Frequency Relevance Heat
Convulsion 6 100.00 Very High Very High Very High
Nervous System Injury 96 99.48 Very High Very High Very High
Neuropathic Pain 176 99.44 Very High Very High Very High
Muscle Weakness 2 99.32 Very High Very High Very High
Pain 94 97.84 Very High Very High Very High
Hypersensitivity 18 93.48 High High
Disease 24 90.88 High High
Alzheimer's Dementia 6 84.96 Quite High
Epilepsy 8 80.72 Quite High
Injury 21 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that the expression level of P2X4 was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade of P2X4 reversed the allodynia.
Negative_regulation (blockade) of P2X4 in spinal cord associated with nervous system injury, allodynia and spinal cord
1) Confidence 0.57 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.12 Pain Relevance 1.05
Here we report that pharmacological blockade of spinal P2X4 receptors (P2X4Rs), a subtype of ionotropic ATP receptor, reversed tactile allodynia caused by peripheral nerve injury without affecting acute pain behaviours in naive animals.
Negative_regulation (blockade) of P2X4Rs in peripheral nerve associated with brush evoked pain, nervous system injury, acute pain and peripheral nerve injury
2) Confidence 0.41 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.26 Pain Relevance 0.84
Thus, blocking P2X4Rs in microglia might be a new therapeutic strategy for pain induced by nerve injury.
Negative_regulation (blocking) of P2X4Rs in nerve associated with pain and nervous system injury
3) Confidence 0.36 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.52 Pain Relevance 0.98
From the pharmacological profiles of TNP-ATP (blocking P2X4 at high concentration) and PPADS (not blocking P2X4), it was inferred that tactile allodynia depends upon P2X4 in the spinal cord.
Negative_regulation (blocking) of P2X4 in spinal cord associated with brush evoked pain and spinal cord
4) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.16 Pain Relevance 0.99
From the pharmacological profiles of TNP-ATP (blocking P2X4 at high concentration) and PPADS (not blocking P2X4), it was inferred that tactile allodynia depends upon P2X4 in the spinal cord.
Negative_regulation (blocking) of P2X4 in spinal cord associated with brush evoked pain and spinal cord
5) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.15 Pain Relevance 0.98
P2X4 receptors were also inhibited by protons, and His286 mediates this effect (Clarke et al., 2000).
Negative_regulation (inhibited) of P2X4
6) Confidence 0.22 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.16
The inhibition of P2X4 receptor activity in microglia might be a new therapeutic strategy for pain induced by nerve injury.
Negative_regulation (inhibition) of P2X4 in microglia associated with pain and nervous system injury
7) Confidence 0.19 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.34 Pain Relevance 0.82
At P2X2 and P2X4 receptors the response was inhibited by MTSES.
Negative_regulation (inhibited) of P2X4
8) Confidence 0.09 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2459275 Disease Relevance 0 Pain Relevance 0.31
P2X2 and P2X4 receptor expression in the hippocampus of seizure-prone gerbils was significantly reduced compared with that of normal gerbils [139].
Negative_regulation (reduced) of P2X4 in hippocampus associated with convulsion and hippocampus
9) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.87 Pain Relevance 0.48

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