INT112431

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 3.52
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
nerve 4
microglia 2
P2rx4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 7 100.00 Very High Very High Very High
Lasting pain 4 99.84 Very High Very High Very High
Brush evoked pain 17 99.80 Very High Very High Very High
allodynia 6 92.88 High High
Pain 8 91.52 High High
Dorsal horn 2 79.36 Quite High
Acute pain 1 78.20 Quite High
Peripheral nerve injury 1 77.04 Quite High
Stimulus evoked pain 1 64.84 Quite High
neuralgia 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 13 99.84 Very High Very High Very High
Neuropathic Pain 23 99.80 Very High Very High Very High
Nervous System Injury 15 98.84 Very High Very High Very High
Injury 2 80.88 Quite High
Hypersensitivity 1 64.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together our results demonstrate that activation of P2X4 or p38 MAPK in spinal cord microglia is necessary for tactile allodynia following nerve injury.
Positive_regulation (necessary) of Positive_regulation (activation) of P2X4 in nerve associated with brush evoked pain, nervous system injury and spinal cord
1) Confidence 0.49 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.07 Pain Relevance 0.91
We report here that tactile allodynia under chronic pain states requires an activation of the P2X4 ionotropic ATP receptor and p38 mitogen-activated protein kinase (MAPK) in spinal cord microglia.
Positive_regulation (requires) of Positive_regulation (activation) of P2X4 in microglia associated with brush evoked pain, lasting pain and spinal cord
2) Confidence 0.49 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.03 Pain Relevance 0.86
Taken together, our results demonstrate that activation of P2X4Rs in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactile allodynia in normal animals.
Positive_regulation (necessary) of Positive_regulation (activation) of P2X4Rs in nerve associated with brush evoked pain and nervous system injury
3) Confidence 0.44 Published 2003 Journal Nature Section Abstract Doc Link 12917686 Disease Relevance 1.42 Pain Relevance 1.04

General Comments

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