INT11244

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 3.61
Pain Relevance 12.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
plasma 2
trigeminal ganglion 2
neuron 2
smooth muscle 1
melanocyte 1
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 252 100.00 Very High Very High Very High
antagonist 43 100.00 Very High Very High Very High
Potency 9 100.00 Very High Very High Very High
qutenza 144 99.92 Very High Very High Very High
substance P 35 99.60 Very High Very High Very High
Neuropeptide 31 98.28 Very High Very High Very High
Clonidine 9 98.00 Very High Very High Very High
trigeminal ganglion 15 97.98 Very High Very High Very High
Dynorphin 5 97.56 Very High Very High Very High
transdermal 13 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fever 6 99.76 Very High Very High Very High
Ganglion Cysts 18 97.98 Very High Very High Very High
Increased Venous Pressure Under Development 17 97.60 Very High Very High Very High
Nociception 4 96.48 Very High Very High Very High
Injury 7 95.88 Very High Very High Very High
Headache 62 95.52 Very High Very High Very High
Pain 31 94.40 High High
Herpes Zoster 3 88.00 High High
Neurogenic Inflammation 3 83.92 Quite High
Migraine Without Aura 2 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The contribution of calcitonin gene-related peptide (CGRP) to neurogenic vasodilator responses.
Transcription (contribution) of CGRP associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.69 Published 1993 Journal Agents Actions Section Title Doc Link 8317313 Disease Relevance 0.07 Pain Relevance 0.81
In conclusion, the morphological findings of co-localization of CGRP-LI and SP-LI in capsaicin-sensitive nerve fibers of the nasal mucosa and trigeminal ganglia of different species including man, coupled with the in vivo description of the high vasodilator potency of CGRP and tachykinins, imply co-release of several vasoactive agents upon activation of the nasal sensory nerves.
Transcription (description) of CGRP in nasal mucosa associated with qutenza, potency, substance p and calcitonin gene-related peptide
2) Confidence 0.68 Published 1989 Journal Cell Tissue Res. Section Abstract Doc Link 2787209 Disease Relevance 0.09 Pain Relevance 0.96
In this preparation, the CGRP receptor antagonist CGRP8–37 (10 ?
Transcription (antagonist) of CGRP associated with antagonist and calcitonin gene-related peptide
3) Confidence 0.68 Published 2007 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC1915621 Disease Relevance 0 Pain Relevance 0.87
In the angiotensin II-induced EPCs senescence, the CGRP mRNA expression was reduced, which was reversed by rutaecarpine.
Transcription (expression) of CGRP
4) Confidence 0.68 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.13 Pain Relevance 0
The results showed that the number of circulating senescent EPCs was significantly increased in hypertension concomitantly with the decreased plasma level of CGRP and the decreased CGRP mRNA expression in EPCs.
Transcription (expression) of CGRP in plasma
5) Confidence 0.68 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.15 Pain Relevance 0
Activation of CGRP receptors in cultured trigeminal ganglion cells increased the cAMP levels, which in turn led to elevated CGRP promoter activity and increased CGRP mRNA levels.
Transcription (levels) of CGRP in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and calcitonin gene-related peptide
6) Confidence 0.67 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.41 Pain Relevance 1.07
The results showed that the number of circulating senescent EPCs was significantly increased in hypertension concomitantly with the decreased plasma level of CGRP and the decreased CGRP mRNA expression in EPCs.
Transcription (expression) of CGRP in plasma
7) Confidence 0.65 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.15 Pain Relevance 0
Finally, a broad variety of biological activities has been described for CGRP-like peptides.
Transcription (described) of CGRP
8) Confidence 0.60 Published 1997 Journal Neurosci Biobehav Rev Section Abstract Doc Link 9353797 Disease Relevance 0.19 Pain Relevance 0.23
The contribution of calcitonin gene-related peptide (CGRP) to neurogenic vasodilator responses.
Transcription (contribution) of gene-related peptide associated with qutenza and calcitonin gene-related peptide
9) Confidence 0.60 Published 1993 Journal Agents Actions Section Title Doc Link 8317313 Disease Relevance 0.07 Pain Relevance 0.81
In donor (unlesioned) DRGs 12.5% of the neuron profiles (NPs) were galanin mRNA-positive (mRNA(+)), 47.5% calcitonin gene-related peptide (CGRP) mRNA(+) and 32.7% substance P mRNA(+).
Transcription (positive) of CGRP in neuron associated with substance p and calcitonin gene-related peptide
10) Confidence 0.60 Published 2003 Journal Neuroscience Section Abstract Doc Link 12654333 Disease Relevance 0.38 Pain Relevance 0.41
In donor (unlesioned) DRGs 12.5% of the neuron profiles (NPs) were galanin mRNA-positive (mRNA(+)), 47.5% calcitonin gene-related peptide (CGRP) mRNA(+) and 32.7% substance P mRNA(+).
Transcription (positive) of calcitonin gene-related peptide in neuron associated with substance p and calcitonin gene-related peptide
11) Confidence 0.60 Published 2003 Journal Neuroscience Section Abstract Doc Link 12654333 Disease Relevance 0.37 Pain Relevance 0.41
The level of CGRP mRNA was detected by RT-PCR, and protein level was measured by radioimmunoassay.
Transcription (level) of CGRP associated with calcitonin gene-related peptide
12) Confidence 0.53 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.26 Pain Relevance 0.72
Hyperthermia also increased the level of CGRP mRNA.
Transcription (level) of CGRP associated with fever and calcitonin gene-related peptide
13) Confidence 0.53 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.27 Pain Relevance 0.92
The level of CGRP mRNA was detected by RT-PCR, and protein level was measured by radioimmunoassay.
Transcription (detected) of CGRP associated with calcitonin gene-related peptide
14) Confidence 0.53 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.26 Pain Relevance 0.72
The level of CGRP mRNA or protein was detected by Real Time-PCR or radioimmunoassay.
Transcription (level) of CGRP associated with calcitonin gene-related peptide
15) Confidence 0.52 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.16
Isolated human pial vessels, intracortical microvessels, and capillaries, as well as cultures of brain endothelial (EC), smooth muscle (SMC), and astroglial (AST) cells, all expressed mRNA for the two cloned CGRP1 receptors; however, message for the K-CGRP1 receptor was barely detectable in microvascular tissues and cells.
Transcription (expressed) of CGRP in smooth muscle
16) Confidence 0.52 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10566974 Disease Relevance 0.20 Pain Relevance 0.40
Clinical therapeutic effect was evaluated at the end of one therapeutic course, and calcitonin gene-related peptide (CGRP) and endotheline (ET) were detected before and after treatment, and the CGRP and ET contents were compared with those in 22 normal persons.
Transcription (detected) of CGRP
17) Confidence 0.52 Published 2007 Journal Zhongguo Zhen Jiu Section Body Doc Link 17853752 Disease Relevance 0.08 Pain Relevance 0
They found that applied bipolar DC current profiles could enhance the absorption of the insulin and calcitonin.
Transcription (absorption) of calcitonin
18) Confidence 0.47 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2527667 Disease Relevance 0 Pain Relevance 0.08
In these DRGs a high proportion of the galanin mRNA(+) NPs contained CGRP mRNA and substance P mRNA.
Transcription (contained) of CGRP in DRGs associated with substance p and calcitonin gene-related peptide
19) Confidence 0.46 Published 2003 Journal Neuroscience Section Abstract Doc Link 12654333 Disease Relevance 0.45 Pain Relevance 0.52
Moderate to low concentrations of immunoreactive processes were detected by calcitonin gene-related peptide, alpha-melanocyte stimulating hormone, dynorphin B, thyrotropin releasing hormone, leucine-enkephalin, dynorphin A, angiotensin II, beta-endorphin, vasopressin and oxytocin antisera, respectively.
Transcription (detected) of calcitonin in melanocyte associated with dynorphin, enkephalin and calcitonin gene-related peptide
20) Confidence 0.44 Published 1992 Journal Neuroscience Section Abstract Doc Link 1542421 Disease Relevance 0 Pain Relevance 1.22

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