INT112447

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

sulfur compound metabolic process (Sult4a1) cytoplasm (Sult4a1)
Anatomy Link Frequency
BAT 2
spinal cords 1
Sult4a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 4 99.00 Very High Very High Very High
monoamine 2 95.56 Very High Very High Very High
Sciatic nerve 1 90.20 High High
Spinal cord 1 88.08 High High
Neuropathic pain 2 84.00 Quite High
Pain 2 83.12 Quite High
orphanin 4 81.04 Quite High
Neuropeptide 2 80.24 Quite High
Clonidine 2 74.44 Quite High
Disease Link Frequency Relevance Heat
Obesity 18 99.84 Very High Very High Very High
Pain 1 83.12 Quite High
Neuropathic Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their spinal cords showed significantly increased ppN/OFQ and NST levels but no change in N/OFQ levels.
Neg (no) Regulation (change) of NST in spinal cords
1) Confidence 0.44 Published 2007 Journal Peptides Section Abstract Doc Link 17583384 Disease Relevance 0.16 Pain Relevance 0.56
Therefore, it is suggested that the regulation of NST in the hamster BAT may be an attractive model to study the role of imidazoline I2b-binding sites.
Regulation (regulation) of NST in BAT associated with obesity
2) Confidence 0.20 Published 2003 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 12919003 Disease Relevance 0.36 Pain Relevance 0.07
The regulation of NST in BAT is linked to the catecholamine metabolism, and the imidazoline I2-binding sites have been found on the monoamine oxidase, a catecholamine metabolising enzyme.
Regulation (regulation) of NST in BAT associated with catecholamine, obesity and monoamine
3) Confidence 0.20 Published 2003 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 12919003 Disease Relevance 0.55 Pain Relevance 0.14

General Comments

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