INT11245

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Context Info
Confidence 0.59
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 1.95
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spike 2
diaphragm 1
muscle 1
SVR 1
skin 1
Dap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 11 98.90 Very High Very High Very High
tetrodotoxin 7 98.52 Very High Very High Very High
Pyramidal cell 4 96.28 Very High Very High Very High
Enkephalin 16 95.04 Very High Very High Very High
anesthesia 12 93.96 High High
Action potential 17 92.64 High High
Intracerebroventricular 4 89.76 High High
Potency 1 85.00 Quite High
addiction 1 78.64 Quite High
Catecholamine 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Fatigue 50 99.22 Very High Very High Very High
Pressure And Volume Under Development 2 93.72 High High
Hypertension 5 93.28 High High
Stroke 1 90.64 High High
Left Ventricular Hypertrophy 7 75.00 Quite High
Emergencies 1 75.00 Quite High
Hypotension 1 75.00 Quite High
Disease 6 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Spinal Cord Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bath application of 2 mM Co2+ depressed the DAP and the DAP-like potential.
Negative_regulation (depressed) of DAP
1) Confidence 0.59 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8395576 Disease Relevance 0 Pain Relevance 0.35
The DAP was blocked when choline replaced all extracellular Na+; there was a hyperpolarizing shift in apparent reversal potential when extracellular Na+ was lowered.
Negative_regulation (blocked) of DAP
2) Confidence 0.54 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1542430 Disease Relevance 0 Pain Relevance 0.09
The DAP was blocked by amiloride (1 mM), which also decreased the preceding Ca2+ plateau.
Negative_regulation (blocked) of DAP
3) Confidence 0.54 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1542430 Disease Relevance 0 Pain Relevance 0.08
However in contrast to the diaphragm, the work fatigue index was similar in the presence and absence of DAP (Figure 5A).
Negative_regulation (absence) of DAP in diaphragm associated with fatigue
4) Confidence 0.37 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2821379 Disease Relevance 0.56 Pain Relevance 0
In DAP-holding voltage curves, the DAP at 10 ms after the spike peak (DAP10) was extrapolated to reverse at about -50 mV.
Negative_regulation (reverse) of DAP in spike
5) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15374744 Disease Relevance 0 Pain Relevance 0.22
Perfusion of tetrodotoxin (TTX; 0.1-1 microM) and replacement of extracellular Na(+) by choline(+) suppressed both spike height and DAP simultaneously.
Negative_regulation (suppressed) of DAP in spike associated with tetrodotoxin
6) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15374744 Disease Relevance 0 Pain Relevance 0.28
The initial increase was followed by progressive declines in work for both untreated and DAP-treated muscle.
Negative_regulation (declines) of DAP in muscle
7) Confidence 0.37 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2821379 Disease Relevance 0.31 Pain Relevance 0
After clonidine treatment, in addition to a statistically significant reduction in SAP, DAP, MAP, and in NE and UNE (all p less than 0.01), a decrease in IVS (12.5 to 9.5 mm; p less than 0.01) and in PW (11.2 to 9.3 mm; p less than 0.01) thickness as well as in LVMI (152.3 to 108.6 g/m2; p less than 0.01) was observed in hypertensive patients.
Negative_regulation (reduction) of DAP associated with hypertension and clonidine
8) Confidence 0.33 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455168 Disease Relevance 0.51 Pain Relevance 0.48
On the other hand, the retro-inverso modification led to a slight improvement in the inhibition of DAP and APN, in the first series of inhibitors, while the inverse result occurred in the second series.
Negative_regulation (inhibition) of DAP
9) Confidence 0.19 Published 1988 Journal J. Med. Chem. Section Abstract Doc Link 2900898 Disease Relevance 0 Pain Relevance 0.19
In contrast, Tyr-Phe-NHOH, designed to interact with S2,S1 subsites through its positively charged Tyr as the P2 component, is a highly potent (Ki = 9 nM) and selective DAP inhibitor.
Negative_regulation (inhibitor) of DAP
10) Confidence 0.16 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3531805 Disease Relevance 0 Pain Relevance 0.33
The compounds synthesized to bind the S1', S2' subsites, such as HN(OH)--CO--CH2--CH(CH2 phi)-CONH--CH(CH2 phi)--COOH, behave as highly potent and mixed inhibitors of both DAP (Ki = 2.5 nM) and enkephalinase (Ki = 0.3 nM).
Negative_regulation (inhibitors) of DAP
11) Confidence 0.16 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3531805 Disease Relevance 0 Pain Relevance 0.38
MS222 induction caused a steady decline in DAP only, while metomidate induction did not affect any cardiovascular variable.
Negative_regulation (decline) of DAP
12) Confidence 0.12 Published 2004 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Abstract Doc Link 15050928 Disease Relevance 0.09 Pain Relevance 0.03
Respiratory rate, SAP, DAP, MAP, T degrees C and pH decreased from pre-induction values, while arterial partial pressures of oxygen and carbon dioxide, bicarbonate concentration, and Pe'CO(2) were significantly higher than baseline.
Negative_regulation (decreased) of DAP in Respiratory
13) Confidence 0.11 Published 2009 Journal Vet Anaesth Analg Section Body Doc Link 19709047 Disease Relevance 0 Pain Relevance 0
In both groups, SAP and DAP decreased significantly after induction; heart rate did not change during our study; and RPP decreased significantly after skin incision.
Negative_regulation (decreased) of DAP in skin
14) Confidence 0.11 Published 1990 Journal Masui Section Abstract Doc Link 1978864 Disease Relevance 0 Pain Relevance 0.24
The dose of clonidine per m2BSA able to reduce by 10% either SAP or DAP (active dose-10), and the dose able to reduce SAP or DAP by 10 mmHg in one minute (systolic or diastolic clonidine unit) were calculated, providing indices for detecting clonidine responsiveness in patients with exaggerated hypertension.
Negative_regulation (reduce) of DAP associated with hypertension and clonidine
15) Confidence 0.10 Published 1983 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6628497 Disease Relevance 0.49 Pain Relevance 0.52
RESULTS: After epidural infusion of bupicacaine (TEA + GA group) or saline (TIVA group), SAP, DAP, HR and SVR in TEA + GA group were statistically decreased in comparing with the baseline, and SAP, DAP, MAP and SVR were also decreased significantly when compared with those in TIVA group (P < or = 0.05).
Negative_regulation (decreased) of DAP in SVR
16) Confidence 0.02 Published 2009 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 19961017 Disease Relevance 0 Pain Relevance 0

General Comments

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