INT112459

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Context Info
Confidence 0.80
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.45
Pain Relevance 6.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gba) carbohydrate metabolic process (Gba) lipid metabolic process (Gba)
lysosome (Gba)
Anatomy Link Frequency
liver 2
bile 2
plasma 1
blood 1
ovary 1
Gba (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 74 100.00 Very High Very High Very High
Bile 21 99.84 Very High Very High Very High
Pain 7 33.96 Quite Low
isoflurane 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Antihistamine 4 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 8 95.36 Very High Very High Very High
Hepatotoxicity 12 95.32 Very High Very High Very High
Disease 39 95.28 Very High Very High Very High
Gauchers Disease 66 85.92 High High
Targeted Disruption 6 76.52 Quite High
Fabry Disease 28 50.00 Quite Low
Hypersensitivity 4 38.48 Quite Low
Death 21 36.80 Quite Low
Necrosis 4 35.32 Quite Low
Pain 8 33.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imig is human recombinant GCase that is secreted from Chinese hamster ovary (CHO) cells with attached complex N-linked oligosaccharides.
Localization (secreted) of GCase in ovary
1) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.06 Pain Relevance 0
Here, similar in vitro enzymatic properties, and in vivo pharmacokinetics and pharmacodynamics (PK/PD) and therapeutic efficacy of GCase were found with two human GCases, recombinant GCase (CHO cell, imiglucerase, Imig) and gene-activated GCase (human fibrosarcoma cells, velaglucerase alfa, Vela), in a Gaucher mouse, D409V/null.
Localization (efficacy) of GCase associated with fibrosarcoma
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2873993 Disease Relevance 0.26 Pain Relevance 0
These results suggest that, although minor, the more rapid clearance of the GCases from the liver in the less involved mice could impact the continued improvement in patients, e.g., as their overall disease, particularly the liver involvement, is reversed, the length of time that their organs experience a therapeutic level of the GCases could be shortened and the rate of reversal could slow [8], [18].
Localization (clearance) of GCase in liver associated with disease
3) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.23 Pain Relevance 0
Standard curves were generated with mouse polyclonal anti-human GCase antiserum (1?
Localization (antiserum) of GCase
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0
In conclusion, basolateral excretion of APAP-GLUC in mice is nearly completely dependent on the function of Mrp3.
Localization (excretion) of APAP-GLUC associated with paracetamol
5) Confidence 0.11 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.22 Pain Relevance 1.37
In the isolated perfused liver, we also found a strong decrease of APAP-GLUC secretion into the perfusate of Mrp3-/- livers.
Localization (secretion) of APAP-GLUC in livers associated with paracetamol
6) Confidence 0.11 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.24 Pain Relevance 1.48
In conclusion, basolateral excretion of APAP-GLUC in mice is nearly completely dependent on the function of Mrp3.
Localization (excretion) of APAP-GLUC associated with paracetamol
7) Confidence 0.10 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.22 Pain Relevance 1.37
In addition, APAP-GLUC excretion in bile of Mrp3-/- mice was tenfold higher than in Mrp3+/+ mice.
Localization (excretion) of APAP-GLUC in bile associated with bile and paracetamol
8) Confidence 0.09 Published 2005 Journal Hepatology Section Abstract Doc Link 16250050 Disease Relevance 0.24 Pain Relevance 1.43
In the case of GLA, other lysosomal hydrolases can be used to assess compound selectivity, such as glucocerebrosidase, ?
Localization (selectivity) of glucocerebrosidase
9) Confidence 0.07 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0 Pain Relevance 0
Interestingly, all of the chemicals increased the plasma concentration and urinary excretion of AA-GLUC and decreased its biliary excretion.
Localization (excretion) of AA-GLUC in plasma
10) Confidence 0.02 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920174 Disease Relevance 0 Pain Relevance 0.27
In control animals, approximately 77% and 23% of AA-GLUC was excreted into bile or urine, respectively, whereas with inducer-pretreated animals, <32% of AA-GLUC was excreted into bile and >68% was excreted into urine.
Localization (excreted) of AA-GLUC in bile associated with bile
11) Confidence 0.02 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920174 Disease Relevance 0 Pain Relevance 0.27
Treatment with the microsomal enzyme inducer trans-stilbene oxide (TSO) can decrease biliary excretion of acetaminophen-glucuronide (AA-GLUC) and increase efflux of AA-GLUC into blood.
Localization (excretion) of AA-GLUC in blood associated with paracetamol
12) Confidence 0.02 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920174 Disease Relevance 0 Pain Relevance 0.22

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