INT11246

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Context Info
Confidence 0.48
First Reported 1980
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 65
Total Number 69
Disease Relevance 14.53
Pain Relevance 36.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
neurons 6
plasma 3
brain 3
dorsal horn 3
dendrites 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 590 100.00 Very High Very High Very High
Glutamate 409 100.00 Very High Very High Very High
Spinal cord 132 100.00 Very High Very High Very High
Glutamate receptor 98 100.00 Very High Very High Very High
agonist 54 100.00 Very High Very High Very High
Neurotransmitter 29 100.00 Very High Very High Very High
Opioid 22 100.00 Very High Very High Very High
Clonidine 10 100.00 Very High Very High Very High
antagonist 125 99.96 Very High Very High Very High
Dynorphin 20 99.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Viral Meningitis 21 99.98 Very High Very High Very High
INFLAMMATION 122 99.76 Very High Very High Very High
Injury 57 99.10 Very High Very High Very High
Neuropathic Pain 171 99.04 Very High Very High Very High
Colitis 48 99.04 Very High Very High Very High
Cognitive Disorder 69 98.92 Very High Very High Very High
Nociception 54 98.40 Very High Very High Very High
Nervous System Injury 10 96.56 Very High Very High Very High
Hypoxia 870 95.84 Very High Very High Very High
Depression 230 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect was inhibited noncompetitively by nanomolar concentrations of strychnine, which differentiates it from the glycine site associated with the N-methyl-D-aspartate receptor.
N-methyl-D-aspartate receptor Binding (associated) of associated with nmda receptor
1) Confidence 0.48 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2338557 Disease Relevance 0 Pain Relevance 0.48
The role of the glycine site associated with the N-methyl-D-aspartate receptor in the induction of long-term potentiation (LTP) was investigated in the dentate gyrus of anesthetized rats.
N-methyl-D-aspartate receptor Binding (associated) of in dentate gyrus associated with nmda receptor and long-term potentiation
2) Confidence 0.47 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1667914 Disease Relevance 0 Pain Relevance 0.34
In dendrites and spines, MOR-IR was localized mainly along nonsynaptic plasma membranes, whereas NR1-IR was more often associated with asymmetric postsynaptic densities and cytoplasmic organelles.
NR1 Binding (associated) of in spines
3) Confidence 0.47 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10440715 Disease Relevance 0 Pain Relevance 0.33
Initially, the subset of members interacting with NR1, the obligatory subunit of all functional NMDA receptor complexes [57], was identified using the Human Interactome Map (HiMAP) database.
NR1 Binding (interacting) of associated with nmda receptor
4) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.30 Pain Relevance 0.14
Third, HiMAP interactome analysis coupled with GSEA analysis allowed us to extend our study to all of the genes that NR1 receptors directly interact with.
NR1 Binding (interact) of
5) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.72 Pain Relevance 0.10
These results are particularly important for a better understanding of certain opioid-mediated neurobehavioral cognitive changes in offspring associated with altered protein interaction between PSD-95 and NMDAR subunits within the developing brain.
NMDAR Binding (interaction) of in brain associated with cognitive disorder, neurobehavioral and opioid
6) Confidence 0.46 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.23 Pain Relevance 0.64
Furthermore, the protein interaction of the synaptic complex between the PSD-95 and NMDAR subunit, as indicated by coimmunoprecipitation, was less in prenatal morphine samples than in vehicle controls (P14 and P45).
NMDAR subunit Binding (interaction) of associated with morphine
7) Confidence 0.46 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.15 Pain Relevance 0.78
The sigma-agonists are believed to interact with the N-methyl-D-aspartate receptor.
N-methyl-D-aspartate receptor Binding (interact) of associated with nmda receptor
8) Confidence 0.44 Published 1992 Journal Stroke Section Abstract Doc Link 1542905 Disease Relevance 0.07 Pain Relevance 0.28
Intrathecal clonidine may act to diminish sympathetic outflow, whereas MK-801 blocks the N-methyl-D-aspartate receptor that is associated with other spinal systems related to pain transmission mechanism.
N-methyl-D-aspartate receptor Binding (associated) of in sympathetic
9) Confidence 0.44 Published 1995 Journal Anesthesiology Section Body Doc Link 7879942 Disease Relevance 0 Pain Relevance 0
The data suggest that genomic interaction among spinal GR, NMDAR, and PKCgamma may be an important mechanism that contributes to the development of morphine tolerance.
NMDAR Binding (interaction) of in spinal associated with tolerance and morphine
10) Confidence 0.42 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.16
Interactions between N-methyl-D-aspartate receptor antagonists and the discriminative stimulus effects of morphine in rats.
N-methyl-D-aspartate receptor Binding (Interactions) of associated with antagonist, nmda receptor and morphine
11) Confidence 0.42 Published 1998 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 9632234 Disease Relevance 0 Pain Relevance 1.02
This binding site was associated with the NMDAR complex because it was modulated by a number of NMDAR ligands.
NMDAR Binding (associated) of
12) Confidence 0.42 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10525097 Disease Relevance 0 Pain Relevance 0.61
NR1 labeling was mainly postsynaptic, associated most often with membranes of cytoplasmic organelles in cell bodies and large dendrites and plasmalemmal surfaces of distal dendrites.
NR1 Binding (associated) of in dendrites associated with nmda receptor
13) Confidence 0.40 Published 2002 Journal Brain Res. Section Abstract Doc Link 12137930 Disease Relevance 0 Pain Relevance 0.68
Immunofluorescence with an antibody that recognized NR1 and another that recognized NR2A and NR2B showed that NR1 and NR2B colocalized in 90% of DRG neurons, including most A-fibers (identified by the presence of neurofilament 200 kDa).
NR1 Binding (recognized) of in neurons
14) Confidence 0.38 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.08 Pain Relevance 0.25
The central action of diclofenac and S(+)-ibuprofen is partly mediated by an interaction with the N-methyl-D-aspartate receptor and nitric oxide-generating mechanisms.
N-methyl-D-aspartate receptor Binding (interaction) of associated with nmda receptor and diclofenac
15) Confidence 0.38 Published 1996 Journal J Clin Pharmacol Section Abstract Doc Link 9013380 Disease Relevance 0.07 Pain Relevance 0.76
We investigated whether the 2 Hz electroacupuncture (EA) analgesia is associated with phosphorylation of N-methyl-D-aspartate receptor (NMDAR) NR-1 subunits and NMDAR antagonism in the lumbar spinal cord of rats.
NR-1 Spec (whether) Binding (associated) of in spinal cord associated with nmda receptor, electroacupuncture, spinal cord and analgesia
16) Confidence 0.37 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 18186585 Disease Relevance 0 Pain Relevance 0.83
However, the injury-induced excessive grooming behavior is only associated with phosphorylation of the NR1 subunit.
NR1 Binding (associated) of associated with injury
17) Confidence 0.37 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12946581 Disease Relevance 0.32 Pain Relevance 0.27
To obtain further insight into the interactions between the N-methyl-D-aspartate receptor and opioid receptor systems, we have investigated the effects of the acute treatment of morphine on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats.
N-methyl-D-aspartate receptor Binding (interactions) of in brain associated with nmda receptor, opioid receptor and morphine
18) Confidence 0.37 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16256980 Disease Relevance 0 Pain Relevance 0.39
Literature-confirmed interactions come from the Human Protein Reference Database, the yeast-two-hybrid-defined interactions come from two recent publications [58,59] and predicted interactions were generated by a Bayesian Analysis [60] From among the >40,000 interactions in the HiMAP network, 32 genes that interact with the NMDAR1 subunit (specifically, the NMDAR1 interactome) were identified (Figure 5A).
NMDAR1 Binding (interact) of
19) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.13 Pain Relevance 0.11
, VEGF, nitric oxide synthase, and glutamate receptor subunits NMDAR1, GluR2, GluR3 were each found to be upregulated at 3 h and 24 h, but all returned to control levels by 14 days.
NMDAR1 Binding (found) of associated with glutamate receptor
20) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.00 Pain Relevance 0.12

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