INT112498

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2003
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 10.76
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (TGM1) transferase activity, transferring acyl groups (TGM1)
Anatomy Link Frequency
eye 1
endothelial cells 1
leukocyte 1
kidney 1
TGM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 6 99.34 Very High Very High Very High
Inflammation 45 98.72 Very High Very High Very High
Inflammatory response 11 93.92 High High
abdominal pain 1 90.16 High High
Serotonin 14 86.72 High High
aspirin 176 83.24 Quite High
cytokine 14 71.60 Quite High
Pain 19 45.72 Quite Low
cINOD 16 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 236 99.82 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 99.34 Very High Very High Very High
Enteritis 5 99.20 Very High Very High Very High
Celiac Disease 16 98.84 Very High Very High Very High
INFLAMMATION 60 98.72 Very High Very High Very High
Corneal Disease 10 98.12 Very High Very High Very High
Autoimmune Disease 26 96.92 Very High Very High Very High
Frailty 2 96.00 Very High Very High Very High
Injury 8 95.60 Very High Very High Very High
Hepatotoxicity 1 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TGase I is expressed in tissues that contain simple epithelia, such as bronchial epithelia, skin epidermis, liver, gastrointestinal tract, kidney, and endothelial cells (23).
Gene_expression (expressed) of TGase I in kidney
1) Confidence 0.55 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 1.01 Pain Relevance 0.11
Serum levels of ANA, IgG and IgA antibodies to TGase, and CIC were measured by ELISA using commercially available kits (BL-Diagnostika GmbH, Mainz, Germany), according to the manufacturer's instructions.


Gene_expression (antibodies) of TGase
2) Confidence 0.47 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0 Pain Relevance 0
Measurements of ANA, IgG and IgA antibodies to TGase, and CIC levels
Gene_expression (Measurements) of TGase
3) Confidence 0.47 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0 Pain Relevance 0
Genital tissue explants (cervicovaginal or penile) were exposed to diluted LiJ (200 ?
Gene_expression (exposed) of LiJ
4) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.42 Pain Relevance 0
In experiments using non-polarized cervicovaginal tissue explants, the toxic nature of LiJ was more apparent, with a 30 minute exposure to 10% LiJ causing significant toxicity, suggesting that toxicity would be higher where the cervicovaginal mucosa was damaged.
Gene_expression (apparent) of LiJ associated with toxicity
5) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.63 Pain Relevance 0
As previously, cells were exposed to LiJ diluted in normal saline for 5, 30 or 60 minutes when cell viability was then determined.
Gene_expression (exposed) of LiJ
6) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.40 Pain Relevance 0
In experiments using non-polarized cervicovaginal tissue explants, the toxic nature of LiJ was more apparent, with a 30 minute exposure to 10% LiJ causing significant toxicity, suggesting that toxicity would be higher where the cervicovaginal mucosa was damaged.
Gene_expression (apparent) of LiJ associated with toxicity
7) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.62 Pain Relevance 0
Media was removed and cells exposed to LiJ (100 ?
Gene_expression (exposed) of LiJ
8) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.27 Pain Relevance 0
The LiJ of twelve limes was processed in this manner, pooled, aliquoted and stored frozen at -80°C until use.
Gene_expression (processed) of LiJ
9) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.55 Pain Relevance 0
As had been observed using cervicovaginal explants, LiJ diluted in saline (0.9% NaCl) was virucidal in both a time and dose-dependent manner, with ?
Gene_expression (virucidal) of LiJ
10) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.39 Pain Relevance 0
Furthermore, a 2 hour exposure to 25% LiJ resulted in 65% reduction in viability and 50% LiJ caused 90% toxicity.
Gene_expression (resulted) of LiJ associated with toxicity
11) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.34 Pain Relevance 0
LiJ was then removed by washing (4 × 200 ?
Gene_expression (removed) of LiJ
12) Confidence 0.31 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.40 Pain Relevance 0
We wonder if this increased expression of transglutaminase 1 may contribute to the increased prevalence of dry eye in women [55].
Gene_expression (expression) of transglutaminase 1 in eye associated with corneal disease
13) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.99 Pain Relevance 0
INTERPRETATION: Antibodies against transglutaminase 6 can serve as a marker in addition to human leukocyte antigen type and detection of anti-gliadin and anti-transglutaminase 2 antibodies to identify a subgroup of patients with gluten sensitivity who may be at risk for development of neurological disease.


Gene_expression (detection) of transglutaminase in leukocyte
14) Confidence 0.23 Published 2008 Journal Ann. Neurol. Section Body Doc Link 18825674 Disease Relevance 0 Pain Relevance 0
TGase I is expressed in tissues that contain simple epithelia, such as bronchial epithelia, skin epidermis, liver, gastrointestinal tract, kidney, and endothelial cells (23).
Gene_expression (expressed) of TGase I in endothelial cells
15) Confidence 0.19 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 1.01 Pain Relevance 0.11
Western analysis demonstrated that transglutaminase II was present in vascular tissue, and transglutaminase activity was observed as a cystamine-inhibitable incorporation of the free amine pentylamine-biotin into arterial proteins.
Gene_expression (present) of transglutaminase
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682564 Disease Relevance 0 Pain Relevance 0.15
We hypothesize that other factors, unique to CD not present in TS or IBS-D, like gluten toxicity and the presence of tissular transglutaminase (tTG) an auto-antigen with pro-inflammatory and remodeling properties, act in addition to intestinal mucosal injury and account to hypertransaminasemia in CD.
Gene_expression (presence) of tissular transglutaminase associated with toxicity, celiac disease, inflammation, enteritis, spastic colon and injury
17) Confidence 0.00 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 16023789 Disease Relevance 2.01 Pain Relevance 0.72
Symptoms were reported to worsen after eating gluten-containing foods, but anti-transglutaminase and anti-endomysial antibodies were negative.
Neg (negative) Gene_expression (negative) of anti-transglutaminase
18) Confidence 0.00 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12924654 Disease Relevance 1.30 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox