INT1125

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Context Info
Confidence 0.69
First Reported 1978
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 130
Total Number 132
Disease Relevance 112.07
Pain Relevance 13.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
plasma cells 7
CSF 7
blood 3
plasma 2
capsule 2
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 35 100.00 Very High Very High Very High
fibrosis 840 99.70 Very High Very High Very High
Multiple sclerosis 95 99.40 Very High Very High Very High
Dismenorea 1 99.36 Very High Very High Very High
cytokine 125 98.76 Very High Very High Very High
Chronic pancreatitis 139 98.16 Very High Very High Very High
Pain 129 98.16 Very High Very High Very High
Bioavailability 4 98.08 Very High Very High Very High
nud 13 97.98 Very High Very High Very High
Inflammation 570 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fever 336 100.00 Very High Very High Very High
Motor Neuron Diseases 91 100.00 Very High Very High Very High
Measles 77 100.00 Very High Very High Very High
Togavirus Infection 60 100.00 Very High Very High Very High
Leukocytosis 9 100.00 Very High Very High Very High
Herpes Zoster 133 99.98 Very High Very High Very High
Epstein-barr Virus 91 99.98 Very High Very High Very High
Thrombocytopenia 24 99.96 Very High Very High Very High
Sclerosing Cholangitis 202 99.88 Very High Very High Very High
Hypersomnia 76 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biologically, the most salient feature of autoimmune pancreatitis was our previous report of a specific augmentation of serum IgG4 levels [21].
Positive_regulation (augmentation) of IgG4 associated with pancreatitis
1) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 1.67 Pain Relevance 0.17
The anti-Toxoplasma titre was elevated in cerebrospinal fluid (57 IU/ml) and in serum (1140 IU/ml), both IgG.
Positive_regulation (elevated) of IgG in cerebrospinal fluid
2) Confidence 0.68 Published 1998 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 9623097 Disease Relevance 0.96 Pain Relevance 0.08
CSF examination was normal except for the increased IgG% and IgG.albumin index.
Neg (except) Positive_regulation (increased) of IgG
3) Confidence 0.56 Published 2000 Journal Rinsho Shinkeigaku Section Abstract Doc Link 10967654 Disease Relevance 0.70 Pain Relevance 0
We think immunological mechanism is important because CSF examination showed increased IgG% and IgG.albumin index in our case.
Spec (examination) Positive_regulation (increased) of IgG
4) Confidence 0.56 Published 2000 Journal Rinsho Shinkeigaku Section Abstract Doc Link 10967654 Disease Relevance 0.91 Pain Relevance 0
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
Positive_regulation (segment) of IgG
5) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.93 Pain Relevance 0.22
Subsequent systemic examinations showed an extremely elevated serum IgG4 level and pancreatitis concordant with AIP.
Positive_regulation (elevated) of IgG4 associated with pancreatitis
6) Confidence 0.49 Published 2006 Journal Int. J. Urol. Section Abstract Doc Link 17083400 Disease Relevance 1.39 Pain Relevance 0.50
INTRODUCTION: Autoimmune pancreatitis is a kind of chronic pancreatitis characterized by the presence of lymphoplasmacytic infiltration and severely elevated serum IgG and IgG4, which has been associated to many extrapancreatic lesions and other autoimmune disorders, leading to the theory of an autoimmune mechanism involved in the pathogenesis of this disease.
Positive_regulation (elevated) of IgG associated with autoimmune disease, pancreatitis, disease and chronic pancreatitis
7) Confidence 0.49 Published 2008 Journal Rev Esp Enferm Dig Section Abstract Doc Link 19119793 Disease Relevance 0.54 Pain Relevance 0.14
IgG4 Fc and IgG4 F(ab')2 were generated through papain [31] and pepsin treatments [32] of purified IgG4 (extracted from pooled patient sera by affinity chromatography as described above) respectively.
Positive_regulation (generated) of IgG4
8) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.07 Pain Relevance 0
Along with IgE, IgG4 has been reported to be elevated in several helminthiasis [23] as well as allergic disorders [24].
Positive_regulation (elevated) of IgG4 associated with helminth infection and hypersensitivity
9) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.93 Pain Relevance 0
Sera from all nine patients with human hookworm infection had IgG, IgG1, IgG2, and IgG3 antibodies to Ac68 and eight of the nine were also positive for IgG4 antibodies.
Positive_regulation (positive) of IgG4 associated with hookworm infection
10) Confidence 0.46 Published 1996 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8686791 Disease Relevance 0.70 Pain Relevance 0.08
The analyses indicated that infection intensity and prevalence in the pre-peak of infection group were significantly lower that those in the peak infection group and this was matched by a significant increase in anti-Sh13 IgG3 levels Comparisons between the age groups where infection intensity peaked and declined showed a reduction albeit non significant in infection intensity and prevalence and antibody levels were largely unchanged remaining high as shown in Figure 5.
Positive_regulation (increase) of IgG3 associated with infection
11) Confidence 0.44 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523344 Disease Relevance 1.45 Pain Relevance 0
Asymptomatic subjects with comparatively short exposure characteristically showed relatively elevated IgG versus IgM reactivity.
Positive_regulation (elevated) of IgG
12) Confidence 0.43 Published 2005 Journal Malar J Section Abstract Doc Link PMC548665 Disease Relevance 0.40 Pain Relevance 0
Repeated examinations of CSF revealed the continuous elevation of IgG.
Positive_regulation (elevation) of IgG
13) Confidence 0.41 Published 1997 Journal Rinsho Shinkeigaku Section Abstract Doc Link 9503968 Disease Relevance 0.77 Pain Relevance 0.28
Small increases in total and parasite-specific IgE and IgG were noted in some volunteers.
Positive_regulation (increases) of IgG
14) Confidence 0.41 Published 1987 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 3605493 Disease Relevance 0.68 Pain Relevance 0.09
Following the report that the isotype distribution of antimalarial antibodies was a critical parameter of malaria immunity [46], various studies confirmed the increase of IgG3 with age, and hence with protection, for many malarial antigens including SIRBC extract, MSP1, MSP2, AMA1, RESA, GLURP, p126-SERP-SERA, EBA 175, TRAP, and Exp1 [28,38,39,45,52,55–62].
Positive_regulation (increase) of IgG3 associated with malaria
15) Confidence 0.38 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.32 Pain Relevance 0
Among the IgGs, the two cytophilic classes, IgG1 and IgG3, were the most abundant (Figure 1) and they both increased as a function of age, whereas the increase was modest for IgG2 and IgM antibodies, and low for IgG4 antibodies in all age groups.
Positive_regulation (increased) of IgG3
16) Confidence 0.38 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.22 Pain Relevance 0
For Pneumo23 vaccination, controls revealed a significant increase of IgG2 and IgG3, whereas post-RTX patients showed an isolated increase of IgG2, and pre-RTX patients, of IgG4 (Figure 1).
Positive_regulation (increase) of IgG3
17) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.61 Pain Relevance 0
For Pneumo23 vaccination, controls revealed a significant increase of IgG2 and IgG3, whereas post-RTX patients showed an isolated increase of IgG2, and pre-RTX patients, of IgG4 (Figure 1).
Positive_regulation (increase) of IgG4
18) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.61 Pain Relevance 0
The surrogate value of anti-MSP3 IgG3 is graphically indicated in Figure 3, in which the risk of occurrence of one or two or more malaria attacks is shown to decrease in adults when the anti-MSP3 IgG3 levels increase.
Positive_regulation (increase) of MSP3 IgG3 associated with malaria
19) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.16 Pain Relevance 0
Notably, the significant increase in the levels of IGHG3 and IGKC in the CSF of NMO patients suggest that immunological mechanisms are involved in the pathophysiology of NMO [23].
Positive_regulation (increase) of IGHG3 associated with neuromyelitis optica
20) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.84 Pain Relevance 0.11

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