INT11250

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 0.08
Pain Relevance 7.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) aging (Fos) extracellular region (Cck)
nucleolus (Fos) nucleus (Fos) DNA binding (Fos)
Anatomy Link Frequency
area postrema 4
brains 4
SON 4
hindbrain 4
PVN 2
Cck (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 63 100.00 Very High Very High Very High
Cholecystokinin 27 100.00 Very High Very High Very High
Locus ceruleus 31 99.68 Very High Very High Very High
vagus nerve 4 99.66 Very High Very High Very High
medulla 1 99.44 Very High Very High Very High
antagonist 19 98.82 Very High Very High Very High
unmyelinated 8 96.32 Very High Very High Very High
Opioid 6 95.44 Very High Very High Very High
Endogenous opioid 6 90.64 High High
narcan 4 85.04 High High
Disease Link Frequency Relevance Heat
Body Weight 1 76.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cholecystokinin-induced c-fos expression in the rat brain stem is influenced by vagal nerve integrity.
Cholecystokinin Positive_regulation (induced) of Gene_expression (expression) of c-fos in brain stem associated with cholecystokinin
1) Confidence 0.78 Published 1992 Journal Exp. Physiol. Section Title Doc Link 1543589 Disease Relevance 0 Pain Relevance 0.38
Pretreatment with the CCK-A receptor antagonist MK-329 (devazepide; 1 mg/kg and 2 mg/kg i.p.) reduced the CCK-induced increase in c-fos expression in the LC/SC by 54% and 75%, respectively; the CCK-B receptor antagonist L-365,260 had no effect.
CCK Positive_regulation (induced) of Gene_expression (expression) of c-fos associated with locus ceruleus and antagonist
2) Confidence 0.75 Published 1997 Journal Brain Res. Section Abstract Doc Link 9372230 Disease Relevance 0 Pain Relevance 0.66
Capsaicin treatment destroys vagal afferent C fibers and markedly attenuates reduction of food intake and induction of hindbrain Fos expression by CCK.
CCK Positive_regulation (induction) of Gene_expression (expression) of Fos in hindbrain associated with qutenza
3) Confidence 0.67 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15905220 Disease Relevance 0 Pain Relevance 0.39
CCK-induced Fos expression was abolished or attenuated in the brains of vagotomized or capsaicin-treated animals.
CCK Positive_regulation (induced) of Gene_expression (expression) of Fos in brains associated with qutenza
4) Confidence 0.66 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996146 Disease Relevance 0 Pain Relevance 0.47
Vagus nerve participates in CCK-induced Fos expression in hindbrain but not myenteric plexus.
CCK Positive_regulation (induced) of Gene_expression (expression) of Fos in hindbrain associated with vagus nerve
5) Confidence 0.66 Published 2000 Journal Brain Res. Section Title Doc Link 10996146 Disease Relevance 0 Pain Relevance 0.47
However, vagotomy or capsaicin treatment did not diminish CCK-induced Fos expression in the small intestinal myenteric plexus.
CCK Neg (not) Positive_regulation (induced) of Gene_expression (expression) of Fos associated with qutenza
6) Confidence 0.66 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996146 Disease Relevance 0 Pain Relevance 0.46
Pretreatment with the CCK-A receptor antagonist MK-329 (devazepide; 1 mg/kg and 2 mg/kg i.p.) reduced the CCK-induced increase in c-fos expression in the LC/SC by 54% and 75%, respectively; the CCK-B receptor antagonist L-365,260 had no effect.
CCK Positive_regulation (increase) of Gene_expression (expression) of c-fos associated with locus ceruleus and antagonist
7) Confidence 0.50 Published 1997 Journal Brain Res. Section Abstract Doc Link 9372230 Disease Relevance 0 Pain Relevance 0.66
Exogenous cholecystokinin (CCK) injected peripherally mimics effects of lipid entering the intestine on food intake and gastric motility via vagal afferents and induces c-fos expression in the locus ceruleus complex (LCC), nucleus of the solitary tract (NTS), area postrema (AP), and paraventricular nucleus (PVN).
CCK Positive_regulation (induces) of Gene_expression (expression) of fos in area postrema associated with locus ceruleus and cholecystokinin
8) Confidence 0.50 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435662 Disease Relevance 0 Pain Relevance 0.36
Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat.
cholecystokinin Positive_regulation (activates) of Gene_expression (expression) of c-fos in locus coeruleus associated with qutenza, locus ceruleus and cholecystokinin
9) Confidence 0.49 Published 1997 Journal Brain Res. Section Title Doc Link 9372230 Disease Relevance 0 Pain Relevance 0.64
In contrast to CCK, gastric distension did significantly increase Fos expression in the NTS of both Veh and Cap rats, although distension-induced Fos was attenuated in Cap rats.
CCK Positive_regulation (increase) of Gene_expression (expression) of Fos
10) Confidence 0.45 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15905220 Disease Relevance 0 Pain Relevance 0.54
We found that CCK (2 or 10 microg/kg) significantly increased Fos expression in both the brains and small intestinal myenteric plexuses of control rats.
CCK Positive_regulation (increased) of Gene_expression (expression) of Fos in brains
11) Confidence 0.44 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996146 Disease Relevance 0 Pain Relevance 0.46
Exogenous cholecystokinin (CCK) injected peripherally mimics effects of lipid entering the intestine on food intake and gastric motility via vagal afferents and induces c-fos expression in the locus ceruleus complex (LCC), nucleus of the solitary tract (NTS), area postrema (AP), and paraventricular nucleus (PVN).
cholecystokinin Positive_regulation (induces) of Gene_expression (expression) of fos in area postrema associated with locus ceruleus and cholecystokinin
12) Confidence 0.44 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435662 Disease Relevance 0 Pain Relevance 0.36
We have studied central opioid inhibition of OXT neurones in late pregnancy by measuring SON OXT neurones firing rate, immediate early gene (Fos) expression and dendritic OXT release under the influence of NLX On day 21 of pregnancy NLX strongly potentiated cholecystokinin (CCK) excitation of OXT neurones increased Fos protein expression and increased intranuclear release of OXT in the SON; NLX was ineffective in virgin rats.
CCK Positive_regulation (increased) of Gene_expression (expression) of Fos in SON associated with cholecystokinin and opioid
13) Confidence 0.36 Published 1994 Journal Gene Ther. Section Abstract Doc Link 8542430 Disease Relevance 0 Pain Relevance 0.65
We have studied central opioid inhibition of OXT neurones in late pregnancy by measuring SON OXT neurones firing rate, immediate early gene (Fos) expression and dendritic OXT release under the influence of NLX On day 21 of pregnancy NLX strongly potentiated cholecystokinin (CCK) excitation of OXT neurones increased Fos protein expression and increased intranuclear release of OXT in the SON; NLX was ineffective in virgin rats.
cholecystokinin Positive_regulation (increased) of Gene_expression (expression) of Fos in SON associated with cholecystokinin and opioid
14) Confidence 0.36 Published 1994 Journal Gene Ther. Section Abstract Doc Link 8542430 Disease Relevance 0 Pain Relevance 0.65
CCK co-injected with leptin potentiated Fos expression selectively in the area postrema, NTS and paraventricular nucleus of the hypothalamus (PVN), which points to the PVN as part of the afferent and efferent limbs of the circuitry involved in the synergistic interaction between leptin and CCK.
CCK Positive_regulation (potentiated) of Gene_expression (expression) of Fos in PVN
15) Confidence 0.10 Published 2000 Journal Regul. Pept. Section Abstract Doc Link 11024569 Disease Relevance 0.08 Pain Relevance 0.13

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