INT112513

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Context Info
Confidence 0.04
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca, Prkce) Golgi apparatus (Prkaca, Prkce) cytoplasm (Prkaca, Prkce)
cytosol (Prkaca, Prkce) nucleus (Prkaca, Prkce) plasma membrane (Prkaca, Prkce)
Anatomy Link Frequency
nociceptors 1
Prkaca (Rattus norvegicus)
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
Hyperalgesia 5 99.46 Very High Very High Very High
nociceptor 2 98.76 Very High Very High Very High
IPN 1 75.00 Quite High
tetrodotoxin 1 63.04 Quite High
addiction 2 56.72 Quite High
Inflammation 2 42.80 Quite Low
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 5 99.46 Very High Very High Very High
Inflammatory Pain 1 75.00 Quite High
INFLAMMATION 1 42.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.
PKA Binding (combination) of PKCepsilon in nociceptors associated with kinase c, hyperalgesia and nociceptor
1) Confidence 0.04 Published 2003 Journal Neuron Section Abstract Doc Link 12925276 Disease Relevance 0.40 Pain Relevance 0.64

General Comments

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