INT112517

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.58
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ephb1, Prkaca) plasma membrane (Ephb1, Prkaca) nucleoplasm (Prkaca)
endosome (Ephb1) mitochondrion (Prkaca) Golgi apparatus (Prkaca)
Anatomy Link Frequency
nociceptors 1
Ephb1 (Rattus norvegicus)
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
Hyperalgesia 5 99.46 Very High Very High Very High
nociceptor 2 98.76 Very High Very High Very High
withdrawal 28 97.80 Very High Very High Very High
Morphine 13 97.36 Very High Very High Very High
narcan 4 97.00 Very High Very High Very High
addiction 3 89.84 High High
Arthritis 43 86.80 High High
Pain 70 86.00 High High
IPN 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 99.46 Very High Very High Very High
Arthritis 63 86.80 High High
Pain 69 86.00 High High
Inflammatory Pain 1 75.00 Quite High
INFLAMMATION 2 46.72 Quite Low
Nociception 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous activation of PKA with forskolin was used to determine the interaction with ERK.
ERK Binding (interaction) of PKA
1) Confidence 0.18 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.17 Pain Relevance 0.16
Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.
ERK Binding (combination) of PKA in nociceptors associated with kinase c, hyperalgesia and nociceptor
2) Confidence 0.16 Published 2003 Journal Neuron Section Abstract Doc Link 12925276 Disease Relevance 0.41 Pain Relevance 0.65
The purpose of the present study was to evaluate the interaction between PKA and extracellular signal-regulated kinase (ERK) signaling pathways mediating the cardiac adaptive changes observed after naloxone administration to morphine-dependent rats.
ERK Binding (interaction) of PKA associated with narcan and morphine
3) Confidence 0.09 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 1.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox