INT11252

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 0
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) aging (Fos) extracellular region (Cck)
nucleolus (Fos) nucleus (Fos) DNA binding (Fos)
Anatomy Link Frequency
dorsal 2
nucleus 2
neurons 1
sympathetic nervous system 1
intestine 1
Cck (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 22 100.00 Very High Very High Very High
Locus ceruleus 11 99.44 Very High Very High Very High
qutenza 31 99.42 Very High Very High Very High
guanethidine 8 99.06 Very High Very High Very High
antagonist 8 97.04 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present experiments show that vagal sensory fibres mediate CCK-induced c-fos in brain stem neurons, based on the findings that perivagal capsaicin pre-treatment in seven out of eight cases reduced or ablated c-fos expression in these regions.
CCK Positive_regulation (induced) of c-fos in neurons associated with qutenza and cholecystokinin
1) Confidence 0.78 Published 1992 Journal Exp. Physiol. Section Abstract Doc Link 1543589 Disease Relevance 0 Pain Relevance 0.28
Guanethidine pretreatment attenuated myenteric but not DVC Fos-LI induced by CCK-8.
CCK Positive_regulation (induced) of Fos associated with guanethidine
2) Confidence 0.56 Published 2005 Journal Brain Res. Section Abstract Doc Link 16298351 Disease Relevance 0 Pain Relevance 0.24
Vagotomy and capsaicin treatment attenuate dorsal vagal complex (DVC) but not myenteric Fos-like immunoreactivity (Fos-LI) induced by cholecystokinin-8 (CCK-8).
CCK Positive_regulation (induced) of Fos in dorsal associated with qutenza and cholecystokinin
3) Confidence 0.56 Published 2005 Journal Brain Res. Section Abstract Doc Link 16298351 Disease Relevance 0 Pain Relevance 0.26
The goal of this experiment is to test the role of the sympathetic nervous system in the pathway by which CCK-8 increases myenteric Fos-LI.
CCK Positive_regulation (increases) of Fos in sympathetic nervous system
4) Confidence 0.56 Published 2005 Journal Brain Res. Section Abstract Doc Link 16298351 Disease Relevance 0 Pain Relevance 0.26
Vagotomy and capsaicin treatment attenuate dorsal vagal complex (DVC) but not myenteric Fos-like immunoreactivity (Fos-LI) induced by cholecystokinin-8 (CCK-8).
cholecystokinin-8 Positive_regulation (induced) of Fos in dorsal associated with qutenza and cholecystokinin
5) Confidence 0.56 Published 2005 Journal Brain Res. Section Abstract Doc Link 16298351 Disease Relevance 0 Pain Relevance 0.26
In Veh rats, intraperitoneal CCK significantly increased DVC Fos, especially in nucleus of the solitary tract (NTS), whereas in Cap rats, CCK did not significantly increase DVC Fos.
CCK Neg (not) Positive_regulation (increase) of Fos in nucleus
6) Confidence 0.39 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15905220 Disease Relevance 0 Pain Relevance 0.53
In Veh rats, intraperitoneal CCK significantly increased DVC Fos, especially in nucleus of the solitary tract (NTS), whereas in Cap rats, CCK did not significantly increase DVC Fos.
CCK Positive_regulation (increased) of Fos in nucleus
7) Confidence 0.39 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15905220 Disease Relevance 0 Pain Relevance 0.48
These findings suggest that entry of lipid into the intestine activates c-fos in the LCC, NTS, and PVN predominantly via CCK-A receptors on vagal afferents and in the AP via vagal and nonvagal pathways, as well as CCK-B and CCK-A receptors.
CCK Positive_regulation (activates) of fos in intestine associated with cholecystokinin
8) Confidence 0.36 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9435662 Disease Relevance 0 Pain Relevance 0.76
Perivagal capsaicin pretreatment diminished the CCK-induced increase in the number of c-Fos-LI-positive cells in the LC/SC by 65%.
CCK Positive_regulation (increase) of c-Fos-LI-positive associated with qutenza and locus ceruleus
9) Confidence 0.13 Published 1997 Journal Brain Res. Section Abstract Doc Link 9372230 Disease Relevance 0 Pain Relevance 0.72

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