INT112530

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.77
Pain Relevance 5.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
testis 2
glial cells 1
alveolar macrophages 1
MMA 1
vas deferens 1
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 106 100.00 Very High Very High Very High
Inflammatory mediators 12 100.00 Very High Very High Very High
COX2 10 100.00 Very High Very High Very High
cOX1 2 100.00 Very High Very High Very High
Spinal cord 2 99.36 Very High Very High Very High
Hyperalgesia 15 99.16 Very High Very High Very High
hyperexcitability 13 98.48 Very High Very High Very High
Antinociceptive 5 94.84 High High
Inflammation 132 93.12 High High
glial activation 3 91.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 172 100.00 Very High Very High Very High
Cancer 48 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
Hyperalgesia 21 99.16 Very High Very High Very High
Stress 10 98.64 Very High Very High Very High
Nociception 13 98.14 Very High Very High Very High
Injury 17 97.68 Very High Very High Very High
Aids-related Complex 147 97.56 Very High Very High Very High
Infection 8 97.28 Very High Very High Very High
Disease 194 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, in primary cultures of rat alveolar macrophages, HN and compounds 1, 2, 6, and 7 (10(-8) M) significantly blocked lipopolysaccharide-induced cyclooxygenase-2 induction and prostaglandin E(2) secretion.
Localization (secretion) of cyclooxygenase-2 in alveolar macrophages
1) Confidence 0.70 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14718586 Disease Relevance 0.50 Pain Relevance 0.55
Localization of cyclooxygenase-2 in mice testis and assessment of its possible role through suppressing its expression using nimesulide: a preferential cyclooxygenase-2 inhibitor.
Localization (Localization) of cyclooxygenase-2 in testis associated with cox2
2) Confidence 0.55 Published 2007 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 17624748 Disease Relevance 0.26 Pain Relevance 0.45
Localization of cyclooxygenase-2 in mice testis and assessment of its possible role through suppressing its expression using nimesulide: a preferential cyclooxygenase-2 inhibitor.
Localization (Localization) of cyclooxygenase-2 in testis associated with cox2
3) Confidence 0.51 Published 2007 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 17624748 Disease Relevance 0.28 Pain Relevance 0.47
Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor.
Localization (Localization) of cyclooxygenase-2 in vas deferens associated with cox1
4) Confidence 0.44 Published 2007 Journal Toxicology Section Title Doc Link 17382448 Disease Relevance 0.17 Pain Relevance 0.47
No increased gene expression was found for prostaglandin-endoperoxide synthase 2 (COX-2), nitric oxide synthase 2 (iNOS or NOS2), or glutathione-S-transferase Pi (GST-Pi) at the 2 day time point for either mouse strain exposed to MMA-SS fume (data not shown).
Localization (found) of prostaglandin-endoperoxide synthase 2 in MMA associated with aids-related complex and sprains and strains
5) Confidence 0.43 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.56 Pain Relevance 0
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Localization (translocation) of cyclooxygenase-2 associated with necrosis and cancer
6) Confidence 0.25 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.25
The inhibition of the canonical targets of NSAIDs, cyclooxygenase-1 and -2 (COX-1 and COX-2), do not seem to be responsible for the protective effect of NSAIDs in AD (see review Lleo et al., 2007).
Localization (targets) of cyclooxygenase-1 and -2 associated with cinod and disease
7) Confidence 0.25 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 1.25 Pain Relevance 0.65
However, the inhibition of the canonical targets of NSAIDs, cyclooxygenase-1 and -2 (COX-1 and COX-2), do not seem to be responsible for the protective effect of NSAIDs in AD.
Localization (targets) of cyclooxygenase-1 and -2 associated with cinod and disease
8) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.49 Pain Relevance 1.14
However, defeminization can occur by an increased level of estradiol [6,33,34], and perhaps masculinization by affecting cyclooxygenase-2 (COX-2) regulation to increase prostaglandin E2 (PGE2) [35].
Localization (increase) of cyclooxygenase-2
9) Confidence 0.18 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.09 Pain Relevance 0
Lipopolysaccharide (LPS) is known to increase the expression and release of various pro-inflammatory mediators, including cyclooxygenase-2 (COX-2) and produce hyperalgesia.
Localization (release) of cyclooxygenase-2 associated with hyperalgesia and inflammatory mediators
10) Confidence 0.18 Published 2004 Journal Inflammopharmacology Section Abstract Doc Link 15035779 Disease Relevance 0.51 Pain Relevance 0.48
Our data confirm the anti-nociceptive activities of the WEDC and indicate that this effect could be associated with inhibition of cyclooxygenase-2 (COX-2) and nitric oxide release.
Localization (release) of cyclooxygenase-2 associated with nociception
11) Confidence 0.14 Published 2003 Journal Life Sci. Section Abstract Doc Link 12927589 Disease Relevance 0.45 Pain Relevance 0.30
Thereafter, COX metabolizes AA into PGG2 and then PGH2, which is transformed further by terminal synthases into specific PG species.
Localization (transformed) of PGH2
12) Confidence 0.14 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.40 Pain Relevance 0.11
Contributing to central hyperexcitability is the activation of N-methyl D-aspartate (NMDA) receptors, and subsequent release of cyclooxygenase-2 (COX-2) in the spinal cord, as well as the activation of glial cells [39,41,42].
Localization (release) of cyclooxygenase-2 in glial cells associated with hyperexcitability and spinal cord
13) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2829507 Disease Relevance 1.30 Pain Relevance 1.01

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