INT112539

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 3.55
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) cell morphogenesis (Hmgb1) nucleolus (Hmgb1)
chromosome (Hmgb1) nucleus (Hmgb1) transcription factor binding (Hmgb1)
Anatomy Link Frequency
spinal 2
dorsal root ganglia 2
dorsal horn 2
Hmgb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 6 99.68 Very High Very High Very High
intrathecal 4 98.64 Very High Very High Very High
dorsal root ganglion 1 97.04 Very High Very High Very High
allodynia 9 96.68 Very High Very High Very High
Pain 8 95.88 Very High Very High Very High
Cancer pain 8 94.40 High High
Hyperalgesia 8 93.80 High High
Inflammation 10 93.28 High High
bradykinin 3 90.32 High High
B1 receptor 1 83.60 Quite High
Disease Link Frequency Relevance Heat
Bone Cancer 10 99.98 Very High Very High Very High
Cancer 6 99.34 Very High Very High Very High
Neuropathic Pain 9 96.68 Very High Very High Very High
Ganglion Cysts 1 96.56 Very High Very High Very High
Pain 4 95.88 Very High Very High Very High
Hyperalgesia 9 95.28 Very High Very High Very High
Cancer Pain 2 94.40 High High
INFLAMMATION 8 93.28 High High
Nociception 2 93.12 High High
Carcinoma 2 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with previous reports, we predict that bone cancer induces HMGB1 production, enhancing spinal IL-1beta expression and thus modulating spinal excitatory synaptic transmission and pain response.
Positive_regulation (induces) of Gene_expression (production) of HMGB1 in spinal associated with pain and bone cancer
1) Confidence 0.70 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399746 Disease Relevance 1.21 Pain Relevance 0.86
Tumor cells inoculation significantly increased HMGB1 expression in the spinal dorsal horn, while intrathecal injecting a neutralizing antibody against HMGB1 showed an effective and reliable anti-allodynia effect with a dose-dependent manner.
Positive_regulation (increased) of Gene_expression (expression) of HMGB1 in dorsal horn associated with allodynia, cancer, spinal dorsal horn and intrathecal
2) Confidence 0.70 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399746 Disease Relevance 1.35 Pain Relevance 1.00
Twenty-four hours after injection of Freund's complete adjuvant into one hindpaw, there was a significant increase in B1 protein expression (measured by immunohistochemistry) in both ipsilateral and contralateral dorsal root ganglion neurones, whereas axotomy resulted in reduction of B1 protein in ipsilateral dorsal root ganglia.
Positive_regulation (increase) of Gene_expression (expression) of B1 protein in dorsal root ganglia associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.47 Published 2003 Journal Pain Section Abstract Doc Link 12927641 Disease Relevance 0.99 Pain Relevance 1.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox