INT112545

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Context Info
Confidence 0.80
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 14.13
Pain Relevance 5.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
chondrocyte 2
B-cell 1
colon 1
nucleus 1
lung 1
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 52 99.34 Very High Very High Very High
Osteoarthritis 130 97.48 Very High Very High Very High
Morphine 15 96.96 Very High Very High Very High
narcan 3 94.64 High High
antagonist 22 93.92 High High
agonist 7 89.72 High High
Inflammation 211 89.20 High High
Arthritis 112 89.12 High High
cytokine 136 88.16 High High
opiate 2 87.52 High High
Disease Link Frequency Relevance Heat
Apoptosis 412 99.92 Very High Very High Very High
Stress 279 99.66 Very High Very High Very High
Leukemia 21 98.18 Very High Very High Very High
Cancer 137 98.08 Very High Very High Very High
Osteoarthritis 144 97.48 Very High Very High Very High
Adenocarcinoma 1 97.42 Very High Very High Very High
Colon Cancer 6 97.10 Very High Very High Very High
Ataxia 2 96.64 Very High Very High Very High
Lymphatic System Cancer 11 96.12 Very High Very High Very High
Epilepsy 2 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we observed that CPS activates ATM kinase that is involved in Ser15, Ser20 and Ser392 p53 phosphorylation as shown by the use of the specific inhibitor KU55933.
Phosphorylation (phosphorylation) of p53 associated with qutenza
1) Confidence 0.80 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 0.92 Pain Relevance 0.51
Interestingly, capsaicin-sensitive leukemic cells were possessed of wild-type p53, resulting in the phosphorylation of p53 at the Ser-15 residue by the treatment of capsaicin.
Phosphorylation (phosphorylation) of p53 associated with qutenza
2) Confidence 0.78 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14871840 Disease Relevance 0.65 Pain Relevance 1.11
Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species.
Phosphorylation (phosphorylation) of p53 associated with stress, qutenza and apoptosis
3) Confidence 0.78 Published 2004 Journal Cancer Res. Section Title Doc Link 14871840 Disease Relevance 0.56 Pain Relevance 0.97
Pretreatment with the antioxidant N-acetyl-L-cystein and catalase, but not superoxide dismutase, completely inhibited capsaicin-induced apoptosis by inhibiting phosphorylation of Ser-15 residue of p53.
Phosphorylation (phosphorylation) of p53 associated with qutenza and apoptosis
4) Confidence 0.78 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14871840 Disease Relevance 0.62 Pain Relevance 1.07
Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.
Phosphorylation (phosphorylated) of p53 in colon associated with colon cancer
5) Confidence 0.75 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.66 Pain Relevance 0.11
It is connected to three genes: TP53 in its active state in the nucleus (through state_transition), TPPP (TPPP can phosphorylate TP53) and MDM2 (MDM2 can inhibit the activation of TP53).
Phosphorylation (phosphorylate) of TP53 in nucleus
6) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.45 Pain Relevance 0
Experiments in A 549 lung adenocarcinoma and in K562 erythroblastoid leukaemia cells have shown that caffeine inhibits ATM and ATR kinases which control checkpoints via phosphorylation of p53 thereby maintaining the G2 block and controlling HR repair [21,24,32,48,51].
Phosphorylation (phosphorylation) of p53 in lung associated with adenocarcinoma and leukemia
7) Confidence 0.60 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.28 Pain Relevance 0.04
In the meanwhile, phosphorylation of p53 at serine 15, accumulation of p53 and increased the expression of its downstream target genes, p21 and Bax induced by ASA.
Phosphorylation (phosphorylation) of p53
8) Confidence 0.54 Published 2003 Journal Eur. J. Clin. Invest. Section Body Doc Link 14511359 Disease Relevance 0.14 Pain Relevance 0
DNA damage can change phosphorylation levels of the p53 protein, resulting in cell cycle arrest and apoptosis [22,23].
Phosphorylation (phosphorylation) of p53 protein associated with apoptosis
9) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.82 Pain Relevance 0
Indeed, phosphorylation of p53 activates the release of cytochrome c and caspase-9 via target genes such as Bax (BCL-2 [B-cell lymphoma-2] associated protein), Bak (BCL-2 homologous antagonist/killer), Noxa (damage), and PUMA (p53 upregulated modulator of apoptosis) [27].
Phosphorylation (phosphorylation) of p53 in B-cell associated with lymphatic system cancer, antagonist and apoptosis
10) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.15 Pain Relevance 0.05
As a transcription factor, the p53 protein is phosphorylated and activated in response to UVB-induced DNA damage. p53 activates genes that can either arrest cell cycle progression, which can provide sufficient time to repair damaged DNA, or initiate programmed cell death (apoptosis) [5].
Phosphorylation (phosphorylated) of p53 protein associated with apoptosis
11) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 1.04 Pain Relevance 0.33
A biotinylated detection antibody specific for human p53 phosphorylated at serine 46 in cell lysates was used to detect phosphorylated protein with a standard streptavidin-HRP method.
Phosphorylation (phosphorylated) of p53
12) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0 Pain Relevance 0.10
At the selected UVB doses, we did not observe any effect of HMW-HA in 8-oxo-dG production or p53 phosphorylation compared with HCE control irradiated cells.


Phosphorylation (phosphorylation) of p53
13) Confidence 0.52 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.14 Pain Relevance 0.09
It was found that induction of apoptosis (characterized by DNA laddering) by actinomycin D was accompanied by a stimulation of the expression of active (phosphorylated) form of p53.
Phosphorylation (phosphorylated) of p53 associated with apoptosis
14) Confidence 0.48 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12927789 Disease Relevance 0.83 Pain Relevance 0.87
Cell viability, reactive oxygen species (ROS) and glutathione (GSH) levels, 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) release, p53 phosphorylation, caspase-3, -8, -9 activation, and interleukin (IL)-6 and -8 production were assessed to evaluate and to compare UVB-induced toxicity between cells treated with HMW-HA and cells treated with PBS.


Phosphorylation (phosphorylation) of p53 associated with toxicity
15) Confidence 0.40 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2660376 Disease Relevance 0.24 Pain Relevance 0.04
However, HMW-HA had no significant effect on ROS and GSH levels, 8-oxo-dG release, and p53 phosphorylation.


Phosphorylation (phosphorylation) of p53
16) Confidence 0.40 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2660376 Disease Relevance 0.24 Pain Relevance 0.04
As shown in Figure 4, UVB radiation (25, 75, and 150 mJ/cm2 of UVB) induced increases in 8-oxo-dG release (+12%, +75%, and +163%, respectively) and in p53 phosphorylation (+102%, +630%, and +710%, respectively) in a dose-dependant manner.
Phosphorylation (phosphorylation) of p53
17) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.14 Pain Relevance 0.07
Furthermore, the results indicate that DNA damage, quantified by apurinic-apyrimidinic site counting assay and phosphorylation of Ser-15 in P53 protein, is induced in CD3+ T cells by morphine in a naloxone-sensitive manner.
Phosphorylation (phosphorylation) of P53 in T cells
18) Confidence 0.40 Published 2009 Journal Biochim. Biophys. Acta Section Body Doc Link 19397953 Disease Relevance 0 Pain Relevance 0
In view of our recent observations suggesting that p53 phosphorylation is regulated by COX-2 in sheared chondrocytes [9], it is not surprising that apoptosis enhancing nuclease (AEN) is also under COX-2 control.
Phosphorylation (phosphorylation) of p53 in chondrocytes associated with apoptosis
19) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.55 Pain Relevance 0.11
Yang et al. have proposed that it has its action by inhibiting extracellular signal-regulated kinase, enhancing the transcriptional activity of p53, and inhibiting p53 phosphorylation.
Phosphorylation (phosphorylation) of p53
20) Confidence 0.34 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.26 Pain Relevance 0.08

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