INT112562

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Context Info
Confidence 0.34
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.25
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
platelets 7
plasma 1
plaques 1
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 98.08 Very High Very High Very High
Angina 30 97.24 Very High Very High Very High
Inflammatory marker 8 87.28 High High
aspirin 21 82.40 Quite High
ischemia 8 79.48 Quite High
Inflammation 98 78.80 Quite High
Inflammatory response 8 76.64 Quite High
Percutaneous transluminal coronary angioplasty 54 65.00 Quite High
anesthesia 3 50.00 Quite Low
antagonist 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 82 100.00 Very High Very High Very High
Necrosis 6 98.68 Very High Very High Very High
Adhesions 75 98.44 Very High Very High Very High
Cancer 6 98.32 Very High Very High Very High
Cv General 3 Under Development 34 97.24 Very High Very High Very High
Rupture 2 96.80 Very High Very High Very High
Cardiovascular Disease 48 95.40 Very High Very High Very High
Coagulation Disorder 9 91.68 High High
Aids-related Complex 64 91.32 High High
Nicotine Addiction 98 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunolocalization of platelet glycoprotein IIb/IIIa and P-selectin, and neutrophil-platelet interaction in human coronary unstable plaques.
P-selectin Binding (interaction) of in plaques
1) Confidence 0.34 Published 2005 Journal Int. J. Mol. Med. Section Title Doc Link 15754016 Disease Relevance 0.84 Pain Relevance 0.67
We measured various platelet activation markers including expressions of PAC-1 and P-selectin, annexin V binding, and microparticle formations by means of whole-blood flow cytometry.
P-selectin Binding (binding) of in platelet
2) Confidence 0.33 Published 2003 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 12928640 Disease Relevance 0 Pain Relevance 0
More than 40% of the Se in human plasma is bound to selenoprotein P (SelP) (Moschos 2000).
SelP Binding (bound) of in plasma
3) Confidence 0.32 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.38 Pain Relevance 0
Finally, a good correlation was found between % inhibition and the percentages of platelets that expressed CD62P or bound PAC-1 (Spearman r = -0.67, p < 0.0001; and -0.49, p < 0.002, respectively; Figure 2).


CD62P Binding (bound) of in platelets associated with heart rate under development
4) Confidence 0.27 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.26 Pain Relevance 0
By flow cytometric analysis, the percentages of platelets that expressed CD62P or bound PAC-1 (median and IQR) were 11.9% (1.8–43%) and 1.8% (0.1–8%) respectively, both significantly lower (p < 0.0002 and p < 0.007, respectively) than the corresponding values in normal controls.
CD62P Binding (bound) of in platelets associated with heart rate under development
5) Confidence 0.27 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.24 Pain Relevance 0
We studied LR in patients with stable angina undergoing elective PCI, all on DAT for at least 7 days, by comparing: 1) Flow cytometry (FC) to measure platelet membrane expression of P-selectin (CD62P) and PAC-1 binding following double stimulation with ADP and collagen type I either in the presence of prostaglandin (PG) E1; 2) VerifyNow-P2Y12 test, in which results are reported as absolute P2Y12-Reaction-Units (PRU) or % of inhibition (% inhibition).


P-selectin Binding (binding) of in platelet associated with heart rate under development and angina
6) Confidence 0.27 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2683811 Disease Relevance 0.35 Pain Relevance 0.14
We studied LR in patients with stable angina undergoing elective PCI, all on DAT for at least 7 days, by comparing: 1) Flow cytometry (FC) to measure platelet membrane expression of P-selectin (CD62P) and PAC-1 binding following double stimulation with ADP and collagen type I either in the presence of prostaglandin (PG) E1; 2) VerifyNow-P2Y12 test, in which results are reported as absolute P2Y12-Reaction-Units (PRU) or % of inhibition (% inhibition).


CD62P Binding (binding) of in platelet associated with heart rate under development and angina
7) Confidence 0.27 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2683811 Disease Relevance 0.35 Pain Relevance 0.14
Another case-control study involving participants from the Women’s Health Study found a significant association between elevated soluble P-selectin levels and CS consumption (

Ridker and others, 2001a

).

P-selectin Binding (association) of
8) Confidence 0.15 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688374 Disease Relevance 0.83 Pain Relevance 0.12
Also, interaction of tissue factor and P-selectin accelerates the rate and extent of fibrin formation [10].
P-selectin Binding (interaction) of
9) Confidence 0.05 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.46 Pain Relevance 0.15
The first contact between leukocytes and the vessel wall is established by members of the selectin family of adhesion molecules: L-selectin (CD62L), which is exclusively expressed by leukocytes; P-selectin (CD62P), which can be found in platelets and Weibel-Palade bodies of endothelial cells; and E-selectin (CD62E), a transcriptionally regulated glycoprotein exclusively expressed by endothelial cells.
CD62P Binding (found) of in platelets associated with adhesions
10) Confidence 0.04 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.77 Pain Relevance 0.11
The first contact between leukocytes and the vessel wall is established by members of the selectin family of adhesion molecules: L-selectin (CD62L), which is exclusively expressed by leukocytes; P-selectin (CD62P), which can be found in platelets and Weibel-Palade bodies of endothelial cells; and E-selectin (CD62E), a transcriptionally regulated glycoprotein exclusively expressed by endothelial cells.
P-selectin Binding (found) of in platelets associated with adhesions
11) Confidence 0.04 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.77 Pain Relevance 0.11

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