INT11258

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 58
Total Number 60
Disease Relevance 21.60
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnas) endosome (Gnas) signal transduction (Gnas)
extracellular region (Gnas) plasma membrane (Gnas) GTPase activity (Gnas)
Anatomy Link Frequency
brain 7
skeletal muscle 2
cerebellum 2
neuronal 2
CAR 1
Gnas (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 13 100.00 Very High Very High Very High
nociceptor 1 99.98 Very High Very High Very High
opioid receptor 11 99.82 Very High Very High Very High
Nucleus accumbens 88 99.44 Very High Very High Very High
Nerve growth factor 12 99.32 Very High Very High Very High
addiction 8 99.32 Very High Very High Very High
agonist 92 98.88 Very High Very High Very High
opiate 3 98.50 Very High Very High Very High
analgesia 9 97.26 Very High Very High Very High
Morphine 16 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Huntington's Chorea 17 100.00 Very High Very High Very High
Injury 173 99.92 Very High Very High Very High
Targeted Disruption 608 99.88 Very High Very High Very High
Death 46 99.80 Very High Very High Very High
Toxicity 65 99.76 Very High Very High Very High
Disease 464 99.58 Very High Very High Very High
Acute-phase Reaction 5 99.12 Very High Very High Very High
Muscular Dystrophy 204 98.96 Very High Very High Very High
Apoptosis 75 97.88 Very High Very High Very High
Cv Unclassified Under Development 13 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STUDY DESIGN: In this cohort study, 1,657 patients who underwent surgical treatment of AN reported their experiences of POH.
Gene_expression (experiences) of POH
1) Confidence 0.58 Published 2005 Journal Laryngoscope Section Body Doc Link 15805885 Disease Relevance 0.37 Pain Relevance 0
Because in the present study performed at 4 days after injury no coexpression of pAkt with GSA and P2X7 was found, the evidence for a preferential apoptotic pathway triggered by P2X7 receptors is unlikely.
Gene_expression (coexpression) of GSA associated with injury and apoptosis
2) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 1.15 Pain Relevance 0.06
In our study, immunocytochemistry showed expression of P2X7 and active caspase 3 at GSA-positive cells after injury without agonist application.
Neg (without) Gene_expression (positive) of GSA associated with injury and agonist
3) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.80 Pain Relevance 0.15
This receptor subtype appeared to be strongly coexpressed with the microglial marker GSA-B4 after the mechanical lesion used in our study, suggesting an outstanding role of this receptor in injury-induced microglial responses.
Gene_expression (coexpressed) of GSA associated with injury
4) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.44 Pain Relevance 0.23
Double immunofluorescence-labeling showed colocalization of active caspase 3 at single GSA-B4-positive cells in the NAc of rats (Fig. 3e,f).
Gene_expression (positive) of GSA associated with nucleus accumbens
5) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.52 Pain Relevance 0.30
While these data confirm previous reports that morphine and heroin analgesia are not mediated by a single mu-opioid receptor, both opiates nonetheless apparently induce dependence via a mu-opioid receptor isoform containing exon 1.
Gene_expression (containing) of exon associated with addiction, opiate, opioid receptor, analgesia and morphine
6) Confidence 0.05 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19429175 Disease Relevance 0 Pain Relevance 2.15
The evoked expression of the immediate-early gene-encoded proteins c-Fos and Krox-24 was used to study activation of mesodiencephalic structures as a function of the development of cyclophosphamide (CP) cystitis in behaving rats.
Gene_expression (expression) of gene-encoded associated with cystitis
7) Confidence 0.04 Published 1997 Journal Exp Brain Res Section Abstract Doc Link 9063711 Disease Relevance 0.23 Pain Relevance 0.14
A transversion at nucleotide 1381 of exon 6 and a C?
Gene_expression (transversion) of exon
8) Confidence 0.03 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 0.09 Pain Relevance 0
The R6/2 mouse, that expresses exon 1 of the human HD gene with an expanded CAG trinucleotide repeat (around 150 CAG repeats) [5], is the most studied transgenic mouse model of HD [6].
Gene_expression (expresses) of exon associated with targeted disruption and disease
9) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 1.60 Pain Relevance 0.11
The rat mu-opioid receptor clone in which novel exon 5 was found in the place of exon 4 (MOR-1B) was one of the first MOR-1 variants described.
Gene_expression (found) of exon associated with opioid receptor
10) Confidence 0.02 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15939800 Disease Relevance 0 Pain Relevance 0.15
Transgenic mice expressing exon 1 of the human Huntington's disease (HD) gene carrying a 115 CAG repeat (line R6/1) are characterized by a neurologic phenotype involving molecular, behavioral and motor disturbances.
Gene_expression (expressing) of exon associated with targeted disruption and disease
11) Confidence 0.02 Published 2003 Journal Neuroscience Section Abstract Doc Link 14643771 Disease Relevance 0.51 Pain Relevance 0.11
An exon 10–11 border amplicon (predicted to be present in both genotypes) was detected in WT and PGC-1??
Gene_expression (detected) of exon
12) Confidence 0.02 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064854 Disease Relevance 0.24 Pain Relevance 0
Treatment of MyoD transfected fibroblasts with the 2L'O-methyl congener of AVI-4658 showed exon skipping in the RT-PCR products (confirmed by sequencing) and dystrophin expression on western blot in all patients (figure 2, webappendix).
Gene_expression (expression) of exon in fibroblasts
13) Confidence 0.02 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.08 Pain Relevance 0
This involved quantification of immunostained, dystrophin-positive fibres, the detection of exon 51 skipped RNA (table 1), and immunoblot analysis.
Gene_expression (detection) of exon
14) Confidence 0.02 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.15 Pain Relevance 0.03
Phosphorodiamidate morpholino oligomers (PMOs; figure 1) are non-toxic, and in the mdx mouse model of DMD they were the most effective oligomer chemistry for inducing exon skipping and restoring long-lasting (weeks) dystrophin expression after intravenous or intramuscular injection.21–24 PMOs, unlike other antisense oligonucleotides, are uncharged, not metabolised, and in preclinical or clinical studies were not associated with activation of the immune system, anaphylaxis, hypotension, or anti-arrhythmias.25 On the basis of these data, we have studied the safety and biochemical efficacy of AVI-4658, a PMO designed to target exon 51 that is delivered by intramuscular injection.
Gene_expression (expression) of exon in immune system associated with pressure volume 2 under development, anaphylaxis and muscular dystrophy
15) Confidence 0.02 Published 2009 Journal Lancet Neurol Section Body Doc Link PMC2755039 Disease Relevance 0.73 Pain Relevance 0
Interestingly, expression of the exon 22-containing isoform was up-regulated in the developing mouse cerebellum, whereas exon 22-skipped isoforms were expressed transiently, peaking at P7.
Gene_expression (expression) of exon in cerebellum
16) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
Interestingly, expression of the exon 22-containing isoform was up-regulated in the developing mouse cerebellum, whereas exon 22-skipped isoforms were expressed transiently, peaking at P7.
Gene_expression (expressed) of exon in cerebellum
17) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
The splicing of exon 22 is interesting for reasons other than the developmental differences in expression; that is, the exon 22-containing isoform was detectable only in the brain, whereas exon 22-skipped isoforms were widely expressed in various tissues.
Gene_expression (expressed) of exon in brain
18) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
The splicing of exon 22 is interesting for reasons other than the developmental differences in expression; that is, the exon 22-containing isoform was detectable only in the brain, whereas exon 22-skipped isoforms were widely expressed in various tissues.
Gene_expression (detectable) of exon in brain
19) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
The tau/GFP reporter was driven by the transgenic E1 promoter, but E4-LI only detected variants expressing the exon 4 sequences.
Gene_expression (expressing) of exon associated with targeted disruption
20) Confidence 0.01 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.22 Pain Relevance 0.25

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