INT112581

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 2.57
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLCG1) signal transduction (PLCG1) plasma membrane (PLCG1)
cytoplasm (PLCG1)
Anatomy Link Frequency
neural 2
PLCG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 18 99.98 Very High Very High Very High
Ventral tegmentum 78 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 12 99.08 Very High Very High Very High
Stress 12 98.48 Very High Very High Very High
Anxiety Disorder 12 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using viral-mediated gene transfer to locally alter the activity of PLCgamma1, we show that overexpression of PLCgamma1 in rostral portions of the VTA (R-VTA) results in increased morphine place preference, whereas PLCgamma1 overexpression in the caudal VTA (C-VTA) results in avoidance of morphine-paired compartments.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PLCgamma1 associated with ventral tegmentum and morphine
1) Confidence 0.32 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930795 Disease Relevance 0.39 Pain Relevance 0.70
In contrast, overexpression of PLCgamma1 in C-VTA decreases preference for sucrose and increases sensitivity to stress and nociceptive stimuli, although there was a tendency for increased anxiety-like behavior as seen for the R-VTA.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PLCgamma1 associated with nociception, stress, ventral tegmentum and anxiety disorder
2) Confidence 0.32 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930795 Disease Relevance 0.58 Pain Relevance 0.78
Using viral-mediated gene transfer to locally alter the activity of PLCgamma1, we show that overexpression of PLCgamma1 in rostral portions of the VTA (R-VTA) results in increased morphine place preference, whereas PLCgamma1 overexpression in the caudal VTA (C-VTA) results in avoidance of morphine-paired compartments.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PLCgamma1 associated with ventral tegmentum and morphine
3) Confidence 0.32 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930795 Disease Relevance 0.45 Pain Relevance 0.75
In addition, overexpression of PLCgamma1 in R-VTA causes increased preference for sucrose and increased anxiety-like behavior but does not affect responses to stress or nociceptive stimuli.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PLCgamma1 associated with nociception, stress, ventral tegmentum and anxiety disorder
4) Confidence 0.23 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930795 Disease Relevance 0.52 Pain Relevance 0.77
In addition, chronic exposure to morphine increases expression of phospholipase Cgamma1 (PLCgamma1) (a protein involved in neurotrophic signaling) in the ventral tegmental area (VTA), a neural substrate for many drugs of abuse.
Positive_regulation (increases) of Gene_expression (expression) of PLCgamma1 in neural associated with ventral tegmentum and morphine
5) Confidence 0.23 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930795 Disease Relevance 0.16 Pain Relevance 0.55
Moreover, these data also support a role for drug-induced elevations in PLCgamma1 expression in the VTA in mediating long-term adaptations to drugs of abuse and aversive stimuli.
Positive_regulation (elevations) of Gene_expression (expression) of PLCgamma1 associated with ventral tegmentum
6) Confidence 0.23 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930795 Disease Relevance 0.47 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox