INT112597

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Msh3) nucleus (Msh3) enzyme binding (Msh3)
DNA binding (Msh3)
Anatomy Link Frequency
tail 1
Msh3 (Mus musculus)
Pain Link Frequency Relevance Heat
tail-flick 6 100.00 Very High Very High Very High
opioid receptor 4 99.72 Very High Very High Very High
agonist 5 99.08 Very High Very High Very High
Antinociceptive 7 95.16 Very High Very High Very High
tolerance 9 94.52 High High
analgesia 2 78.64 Quite High
antagonist 1 56.24 Quite High
antinociception 1 54.32 Quite High
mu opioid receptor 1 48.16 Quite Low
Spinal cord 1 45.84 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EM-1 (16.3 nM), while pretreatment with EM-2 (70 nM) for 0.5-1.5 h, but not 2 h, attenuated tail-flick inhibition induced by i.t.
Positive_regulation (induced) of EM-1 in tail associated with tail-flick
1) Confidence 0.25 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12932813 Disease Relevance 0 Pain Relevance 0.46
Administration of endomorphin-1 (EM-1, a mu-opioid receptor agonist) or deltorphin I (del I, a delta-opioid receptor agonist) twice daily for 4 days produced antinociceptive tolerance compared with vehicle controls.
Positive_regulation (Administration) of EM-1 associated with tolerance, agonist, opioid receptor and antinociceptive
2) Confidence 0.10 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17568695 Disease Relevance 0 Pain Relevance 0.96

General Comments

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