INT1126

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 46
Total Number 46
Disease Relevance 31.07
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD79A)
Anatomy Link Frequency
blood 2
B cells 2
saliva 2
macrophage 1
glomerular capillary 1
CD79A (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 39 99.80 Very High Very High Very High
Inflammation 116 99.72 Very High Very High Very High
cytokine 76 98.56 Very High Very High Very High
rheumatoid arthritis 129 98.52 Very High Very High Very High
abdominal pain 16 98.40 Very High Very High Very High
Central nervous system 3 98.14 Very High Very High Very High
Pain 33 98.08 Very High Very High Very High
Acupuncture 130 97.88 Very High Very High Very High
cva 3 95.24 Very High Very High Very High
corticosteroid 36 94.40 High High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 5 99.96 Very High Very High Very High
Agammaglobulinemia 50 99.92 Very High Very High Very High
Tabes Dorsalis 4 99.92 Very High Very High Very High
Malabsorption Syndromes 116 99.90 Very High Very High Very High
Stress 50 99.80 Very High Very High Very High
Low Back Pain 40 99.80 Very High Very High Very High
INFLAMMATION 111 99.72 Very High Very High Very High
Immunodeficiency 6 99.62 Very High Very High Very High
Embolism 1 99.60 Very High Very High Very High
Renal Insufficiency 3 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There have been several reports in the literature indicating coexistence of AS with selective IgA deficiency.
Negative_regulation (deficiency) of IgA associated with spinal inflammation
1) Confidence 0.59 Published 1997 Journal J Investig Allergol Clin Immunol Section Abstract Doc Link 9491204 Disease Relevance 0.36 Pain Relevance 0.45
Selective IgA deficiency and ankylosing spondylitis.
Negative_regulation (deficiency) of IgA associated with spinal inflammation
2) Confidence 0.59 Published 1997 Journal J Investig Allergol Clin Immunol Section Title Doc Link 9491204 Disease Relevance 0.39 Pain Relevance 0.47
A man with an ankylosing spondylitis (AS) and selective IgA deficiency is described.
Negative_regulation (deficiency) of IgA associated with spinal inflammation
3) Confidence 0.59 Published 1997 Journal J Investig Allergol Clin Immunol Section Abstract Doc Link 9491204 Disease Relevance 0.37 Pain Relevance 0.45
A decrease of IgG and IgA during pregnancy was found in all women while levels of IgM and alloantibodies remained stable.
Negative_regulation (decrease) of IgA
4) Confidence 0.57 Published 1983 Journal J Clin Lab Immunol Section Abstract Doc Link 6604163 Disease Relevance 0.37 Pain Relevance 0.23
After addition of IFN-alpha to the modified M-2 protocol, a rapid reduction in the level of serum IgA was found and clinical symptoms including bone pain, anaemia and so on were dramatically improved.
Negative_regulation (reduction) of IgA associated with pain and anaemia
5) Confidence 0.53 Published 1991 Journal Haematologia (Budap) Section Abstract Doc Link 1813363 Disease Relevance 0.43 Pain Relevance 0.10
Lambda light chains were the sole contributors to a selective increase in IgD, with a concomitant reduction of IgA, IgG, and IgM.
Negative_regulation (reduction) of IgA
6) Confidence 0.50 Published 1981 Journal J. Neurol. Section Abstract Doc Link 6169807 Disease Relevance 0.99 Pain Relevance 0.15
As it is suggested in the literature, we believe that selective IgA deficiency is a poor prognostic factor in AS.
Negative_regulation (deficiency) of IgA associated with spinal inflammation
7) Confidence 0.43 Published 1997 Journal J Investig Allergol Clin Immunol Section Abstract Doc Link 9491204 Disease Relevance 0.45 Pain Relevance 0.45
In addition, the new assay detects the presence of selective IgA deficiency, which shows a 10-fold increase in prevalence in patients with celiac disease compared to the general population.
Negative_regulation (deficiency) of IgA associated with celiac disease
8) Confidence 0.43 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17785322 Disease Relevance 0.60 Pain Relevance 0.07
The laboratory findings of M-proteinemia (IgA 1215 mg/dl) with the decrease of other serum immunoglobulin level (IgG 611 mg/dl, IgM 60 mg/dl) and monoclonal IgA[symbol: see text]-type light chain in serum immunoelectrophoresis suggested MM four years ago.
Negative_regulation (decrease) of IgA associated with multiple myeloma
9) Confidence 0.43 Published 2000 Journal Ryumachi Section Abstract Doc Link 10783663 Disease Relevance 1.41 Pain Relevance 0.34
Immunofluorescence revealed predominantly mesangial deposits of IgA and IgG but no IgM nor complement.
Negative_regulation (deposits) of IgA
10) Confidence 0.42 Published 1978 Journal Am. J. Med. Sci. Section Abstract Doc Link 153712 Disease Relevance 0.79 Pain Relevance 0.09
Immunofluorescence revealed a granular deposition of IgA predominantly in the mesangial area in contrast to the granular IgG deposition along the glomerular capillary loops.
Negative_regulation (deposition) of IgA in glomerular capillary
11) Confidence 0.41 Published 2002 Journal Clin. Nephrol. Section Abstract Doc Link 12078954 Disease Relevance 0.75 Pain Relevance 0.09
A lower level of IgA, IgG and lysozyme was only noted in individuals with occupational exposure exceeding 20 years.
Negative_regulation (level) of IgA
12) Confidence 0.41 Published 1991 Journal J Hyg Epidemiol Microbiol Immunol Section Abstract Doc Link 1725175 Disease Relevance 0.50 Pain Relevance 0.08
Henoch-Schönlein purpura (HSP) is a form of cutaneous small vessel vasculitis that can involve visceral organs and is associated with deposition of immunoglobulin A (IgA)-containing immune complexes.
Negative_regulation (deposition) of IgA in visceral organs associated with purpura and increased venous pressure under development
13) Confidence 0.41 Published 2006 Journal Cutis Section Abstract Doc Link 16706241 Disease Relevance 1.38 Pain Relevance 0.08
The CFA effectively removed 93% of CG, without significant removal of IgG, IgM, IgA, albumin, and fibrinogen.
Negative_regulation (removal) of IgA
14) Confidence 0.39 Published 1999 Journal ASAIO J. Section Abstract Doc Link 10360729 Disease Relevance 1.28 Pain Relevance 0.07
We demonstrated that the autoantibodies detected by ANA were not of the IgA isotype, so it is possible that the IgA antibodies are simply elicited by nonspecific chronic inflammatory processes in these individuals.
Negative_regulation (elicited) of IgA associated with inflammation
15) Confidence 0.38 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253705 Disease Relevance 0.74 Pain Relevance 0.22
Surgical biopsy of the ileum revealed deposits of IgA, C3, and fibrin in segments of the wall of submucosal arteries.
Negative_regulation (deposits) of IgA in ileum
16) Confidence 0.38 Published 1984 Journal Am. J. Med. Section Abstract Doc Link 6385695 Disease Relevance 0.70 Pain Relevance 0.25
No statistically significant difference was observed in the prevalence of IgA or IgG antibodies to bovine and human tTg and in the frequency and in mean level of IgA or IgG ASCA between the studied groups or between each group and healthy controls.
Negative_regulation (prevalence) of IgA
17) Confidence 0.32 Published 2004 Journal J. Rheumatol. Section Body Doc Link 15124251 Disease Relevance 0.12 Pain Relevance 0
Immunofluorescence studies revealed intensive deposition of IgG, IgA, C3, C1q, Fibrinogen, and kappa light chain with granular pattern in the capillary and mesangial area.
Negative_regulation (deposition) of IgA in capillary
18) Confidence 0.29 Published 2009 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 19367362 Disease Relevance 0.77 Pain Relevance 0.27
Rapidly progressive tabes dorsalis associated with selective IgA deficiency.
Negative_regulation (deficiency) of IgA associated with tabes dorsalis
19) Confidence 0.28 Published 2001 Journal Intern. Med. Section Title Doc Link 11579969 Disease Relevance 0.73 Pain Relevance 0.13
If the level of anti-tTG was <0.1 IU/ml, the total serum IgA level was measured for ruling out IgA deficiency.


Negative_regulation (deficiency) of IgA
20) Confidence 0.23 Published 2008 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702920 Disease Relevance 0.24 Pain Relevance 0

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