INT11261

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Context Info
Confidence 0.50
First Reported 1985
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 4.40
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTPLA) lyase activity (PTPLA) endoplasmic reticulum (PTPLA)
Anatomy Link Frequency
nerves 1
PTPLA (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 46 100.00 Very High Very High Very High
qutenza 9 100.00 Very High Very High Very High
Endogenous opioid 3 99.84 Very High Very High Very High
spinothalamic tract 6 99.34 Very High Very High Very High
cva 10 94.52 High High
Pain 22 93.60 High High
excitatory amino acid 4 92.96 High High
agonist 2 92.08 High High
noradrenaline 3 90.04 High High
Glutamate 1 90.00 High High
Disease Link Frequency Relevance Heat
Abdominal Pain 46 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 100.00 Very High Very High Very High
Communicable Diseases 2 99.98 Very High Very High Very High
Mycobacterial Infection 1 99.60 Very High Very High Very High
Disease 12 98.00 Very High Very High Very High
Gastrointestinal Disease 6 95.68 Very High Very High Very High
Cv General 3 Under Development 10 94.52 High High
Pain 27 93.60 High High
Atherosclerosis 7 91.76 High High
Diabetes Mellitus 23 90.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that endogenous opioids do not mediate the pharmacological actions of CAP.
Neg (not) Positive_regulation (mediate) of CAP associated with endogenous opioid
1) Confidence 0.50 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 3003298 Disease Relevance 0.21 Pain Relevance 0.53
Our results show that the background discharge rate and the responses of STT cells to mechanical stimulation increase following intradermal CAP.
Positive_regulation (increase) of CAP associated with spinothalamic tract and qutenza
2) Confidence 0.36 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1545244 Disease Relevance 0.48 Pain Relevance 1.93
Thus FAAH CA/AA increases the odds (relative to HV) for D-IBS (P = 0.008), M-IBS (P = 0.012), and, possibly, CAP (P = 0.055).
Spec (possibly) Positive_regulation (increases) of CAP associated with abdominal pain
3) Confidence 0.21 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962356 Disease Relevance 0.87 Pain Relevance 0.48
Patients with infectious diseases causing CAP, such as tuberculosis, yersiniosis and Whipple's disease may present with abdominal wall rigidity due to activation of primary afferent visceral and cutaneous pain nerves [20,21].
Positive_regulation (causing) of CAP in nerves associated with mycobacterial infection, pain, abdominal pain, communicable diseases and disease
4) Confidence 0.14 Published 2008 Journal Cases J Section Body Doc Link PMC2556666 Disease Relevance 2.19 Pain Relevance 0.80

General Comments

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